Molecular structure of Fumagillin, CAS Number: 23110-15-8
Fumagillin (CAS 23110-15-8)
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Application:
Fumagillin is an angiogenesis suppressing antibiotic and MetAP-2 inhibitor
CAS Number:
23110-15-8
Purity:
≥95%
Molecular Weight:
458.60
Molecular Formula:
C26H34O7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Fumagillin is a complex natural product antibiotic which covalently binds a key histidine residue of methionine aminopeptidase type II (MetAP-2), inhibiting endothelial cell proliferation and angiogenesis. This stops the growth and development of organisms. Fumagillin may act to have antibacterial, antifungal, and antiparasitic activity. It has been used in scientific research to study the effects of antibiotics on the growth of bacteria, the expression of genes associated with antibiotic resistance, and the effects of antibiotics on the biofilm formation of bacteria.
Fumagillin (CAS 23110-15-8) References
- Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth. | Ingber, D., et al. 1990. Nature. 348: 555-7. PMID: 1701033
- Potent anti-angiogenic action of AGM-1470: comparison to the fumagillin parent. | Kusaka, M., et al. 1991. Biochem Biophys Res Commun. 174: 1070-6. PMID: 1705118
- Fumagillin: an anti-infective as a parent molecule for novel angiogenesis inhibitors. | Lefkove, B., et al. 2007. Expert Rev Anti Infect Ther. 5: 573-9. PMID: 17678422
- In vitro evaluation of the clastogenicity of fumagillin. | Stevanovic, J., et al. 2008. Environ Mol Mutagen. 49: 594-601. PMID: 18613037
- Nosema ceranae escapes fumagillin control in honey bees. | Huang, WF., et al. 2013. PLoS Pathog. 9: e1003185. PMID: 23505365
- Stability of dicyclohexylamine and fumagillin in honey. | van den Heever, JP., et al. 2015. Food Chem. 179: 152-8. PMID: 25722149
- Fumagillin, a potent angiogenesis inhibitor, induces Kaposi sarcoma-associated herpesvirus replication in primary effusion lymphoma cells. | Kanno, T., et al. 2015. Biochem Biophys Res Commun. 463: 1267-72. PMID: 26093300
- Spiroepoxytriazoles Are Fumagillin-like Irreversible Inhibitors of MetAP2 with Potent Cellular Activity. | Morgen, M., et al. 2016. ACS Chem Biol. 11: 1001-11. PMID: 26686773
- Efficacy of fumagillin bicyclohexylamine on experimental corneal neovascularization in rat model. | Aşula, MF., et al. 2019. Int Ophthalmol. 39: 1553-1558. PMID: 30006905
- A possible role for fumagillin in cellular damage during host infection by Aspergillus fumigatus. | Guruceaga, X., et al. 2018. Virulence. 9: 1548-1561. PMID: 30251593
- NF-κB Inhibitory and Antibacterial Helvolic and Fumagillin Derivatives from Aspergillus terreus. | Zaman, KAU., et al. 2020. J Nat Prod. 83: 730-737. PMID: 32163285
- Safety and efficacy of fumagillin for the treatment of intestinal microsporidiosis. A French prospective cohort study. | Maillard, A., et al. 2021. J Antimicrob Chemother. 76: 487-494. PMID: 33128055
- Potential of Fumagillin and Agaricus blazei Mushroom Extract to Reduce Nosema ceranae in Honey Bees. | Glavinic, U., et al. 2021. Insects. 12: PMID: 33806001
- The anti-angiogenic agent fumagillin covalently modifies a conserved active-site histidine in the Escherichia coli methionine aminopeptidase. | Lowther, WT., et al. 1998. Proc Natl Acad Sci U S A. 95: 12153-7. PMID: 9770455
Inhibitor of:
ALG10, CLEC-14A, CTDSP1, GALE, LYG2, MetAP-2, MFAP1, MLEC, PMM2, Protease, Sciellin, SOAT1, Thrombospondin 1, and Vmn2r1.Activator of:
APLNR, EGFL6, Endoglin, MetAP-1, and neuropilin.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Fumagillin, 1 mg | sc-200377 | 1 mg | $102.00 | |||
Fumagillin, 5 mg | sc-200377A | 5 mg | $385.00 | |||
Fumagillin, 25 mg | sc-200377B | 25 mg | $530.00 | |||
Fumagillin, 100 mg | sc-200377C | 100 mg | $1336.00 | |||
Fumagillin, 500 mg | sc-200377D | 500 mg | $5110.00 |