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Forskolin (CAS 66575-29-9)

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Alternate Names:
Colforsin; Coleonol;7β-Acetoxy-8,13-epoxy-1α,6β,9α-trihydroxylabd-14-en-11-one
Application:
Forskolin is an adenylate cyclase activator and MAP kinase inhibitor
CAS Number:
66575-29-9
Purity:
≥98%
Molecular Weight:
410.50
Molecular Formula:
C22H34O7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Forskolin is a diterpenoid that interacts directly with the catalytic subunit of A cyclase (adenylate cyclase), activating the enzyme and raising intracellular levels of cAMP. Forskolin is cell permeable and active in vivo producing positive inotropic, platelet anti-aggregatory and anti-hypertensive effects in vitro. Has also been shown to exhibit smooth muscle relaxant activity, decrease in intraocular pressure and the promotion of hormonal release from the pituitary glands in vitro. Inhibits MAP kinase, induces phosphorylation of CREB, connexin 43, Bad, ATF-1 and PKB. Forskolin is an inhibitor of AChR.


Forskolin (CAS 66575-29-9) References

  1. Intestinal permeability of forskolin by in situ single pass perfusion in rats.  |  Liu, ZJ., et al. 2012. Planta Med. 78: 698-702. PMID: 22411728
  2. Forskolin: a specific stimulator of adenylyl cyclase or a diterpene with multiple sites of action?  |  Laurenza, A., et al. 1989. Trends Pharmacol Sci. 10: 442-7. PMID: 2692256
  3. Forskolin, a hedgehog signalling inhibitor, attenuates carbon tetrachloride-induced liver fibrosis in rats.  |  El-Agroudy, NN., et al. 2016. Br J Pharmacol. 173: 3248-3260. PMID: 27590029
  4. Forskolin and caffeine induce Ca2+ release from intracellular stores in rabbit aorta.  |  Hai, CM. and Phair, RD. 1989. Am J Physiol. 257: C413-8. PMID: 2782384
  5. Treatment with chemical delipidation forskolin prior to cryopreservation improves the survival rates of swamp buffalo (Bubalus bubalis) and bovine (Bos indicus) in vitro produced embryos.  |  Panyaboriban, S., et al. 2018. Cryobiology. 84: 46-51. PMID: 30092172
  6. Forskolin: its biological and chemical properties.  |  Seamon, KB. and Daly, JW. 1986. Adv Cyclic Nucleotide Protein Phosphorylation Res. 20: 1-150. PMID: 3028083
  7. Forskolin reduces fat accumulation in Nile tilapia (Oreochromis niloticus) through stimulating lipolysis and beta-oxidation.  |  Zhang, H., et al. 2019. Comp Biochem Physiol A Mol Integr Physiol. 230: 7-15. PMID: 30593869
  8. Forskolin induced remodeling of lipid droplets in rat adipocytes.  |  Liu, MF., et al. 2019. Sheng Li Xue Bao. 71: 379-387. PMID: 31218328
  9. Progress in heterologous biosynthesis of forskolin.  |  Ju, H., et al. 2021. J Ind Microbiol Biotechnol. 48: PMID: 33928347
  10. The role of forskolin as a lipolytic stimulator during in vitro oocyte maturation and the in vitro embryo production of livestock.  |  Raza, SHA., et al. 2021. Reprod Domest Anim. 56: 1486-1496. PMID: 34592022
  11. Intraperitoneal Administration of Forskolin Reverses Motor Symptoms and Loss of Midbrain Dopamine Neurons in PINK1 Knockout Rats.  |  Vazquez-Mayorga, E., et al. 2022. J Parkinsons Dis. 12: 831-850. PMID: 34957950
  12. The effects of metformin and forskolin on sperm quality parameters and sexual hormones in type II diabetic male rats.  |  Naghibi, M., et al. 2022. Andrologia. 54: 1605-1617. PMID: 35396719
  13. Forskolin alleviates cisplatin-induced acute renal toxicity in rats.  |  El-Naga, RN. 2022. J Pharm Pharmacol. 74: 1051-1060. PMID: 35512548
  14. Anti-Melanogenesis Effect of Polysaccharide from Saussurea involucrata on Forskolin-Induced Melanogenesis in B16F10 Melanoma Cells.  |  Kamilijiang, M., et al. 2022. Nutrients. 14: PMID: 36501075
  15. Forskolin: a labdane diterpenoid with antihypertensive, positive inotropic, platelet aggregation inhibitory, and adenylate cyclase activating properties.  |  de Souza, NJ., et al. 1983. Med Res Rev. 3: 201-19. PMID: 6345959

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Forskolin, 5 mg

sc-3562
5 mg
$76.00

Forskolin, 50 mg

sc-3562A
50 mg
$150.00

Forskolin, 1 g

sc-3562B
1 g
$725.00

Forskolin, 2 g

sc-3562C
2 g
$1385.00

Forskolin, 5 g

sc-3562D
5 g
$2050.00

How long is your Forskolin stable in DMSO in the -20?

Asked by: Anonymous
Thank you for your question. DMSO stock solutions are stable for up to 4 months at 4°C. We can not find any info on freezing the solution.
Answered by: Technical Support
Date published: 2020-02-26

We are planning to switch this compound from SIGMA to Santa Cruz. Can you provide us the trial so that we can test the repeatability of data?

Asked by: Shogo
Thank you for your question. We do not provide sample sizes for any of our chemical reagents. We do offer a satisfaction guarantee. Any product that does not meet the performance standards indicated in our product literature will be replaced at no charge. Our policy is valid for one year from the date of purchase.
Answered by: Technical Support
Date published: 2018-11-19

Can Forskolin be filtered through a 0.2 micron filter?

Asked by: ChemSynth123
Thank you for your question. Forskolin (CAS 66575-29-9): sc-3562, is probably only about a nanometer across. If it is truly in solution, and not a suspension of particles (especially >0.2 µm, of course), it should pass through the 0.2 micron filter just fine.
Answered by: Chemical Support 7
Date published: 2017-03-01
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Rated 5 out of 5 by from Very goodWe used to induce syncytialization in BeWo cell line and worked perfectly
Date published: 2025-01-21
Rated 5 out of 5 by from We use this routinely in our lab and it worksWe use this routinely in our lab and it works great.
Date published: 2015-08-31
Rated 5 out of 5 by from VitoloVitolo, et. al. (PubMed ID 12244210) found that forskolin triggers PKA Kinase activity and promotes the recovery of LTP formation. -SCBT Publication Review
Date published: 2015-06-13
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Forskolin is rated 5.0 out of 5 by 3.
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