Date published: 2025-10-17

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Formic acid (CAS 64-18-6)

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Application:
Formic acid is a carboxylic acid used in the reduction of aldehydes to alcohols
CAS Number:
64-18-6
Purity:
≥97%
Molecular Weight:
46.03
Molecular Formula:
CH2O2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Formic acid, the smallest of the carboxylic acids, was observed in the 17th century from the distillation of ants. Formic acid is utilized in a variety of large scale applications, which include the dyeing of natural and synthetic fibers, feed and fodder preservation, leather tanning, the production of commercial cleaning products, and rubber coagulation. In organic synthesis, formic acid has been used in the synthesis of such classes of compounds as coumarins, optically active styrene oxides, and polyamide oligomers based on 14-amino-3,6,9,12-tetraoxatetradecanoic acid. Formic acid has been used in the mobile phase for various LC-MS analytical methods, such as an LC-MS study of spiroketal stereoisomers of pectenotoxins and an LC/ESI-MS/UV photodiode array method for the analysis of flavonoid glycosides. A method to measure internal nucleoside triphosphate pools of lactococci that uses formic acid in the chromatographic separation has been described. The use of formic acid in the separation and detection of intact proteins by reversed-phase LC/ESI-MS by flow injection analysis has been reported. A method of protein hydrolysis using formic acid for MS analysis has been published.


Formic acid (CAS 64-18-6) References

  1. Methanol and formic acid toxicity: biochemical mechanisms.  |  Liesivuori, J. and Savolainen, H. 1991. Pharmacol Toxicol. 69: 157-63. PMID: 1665561
  2. FASD: folic acid and formic acid - an unholy alliance in the alcohol abusing mother.  |  Kapur, BM. and Baber, M. 2018. Biochem Cell Biol. 96: 189-197. PMID: 28793200
  3. Cobalt-Catalyzed Aqueous Dehydrogenation of Formic Acid.  |  Zhou, W., et al. 2019. Chemistry. 25: 8459-8464. PMID: 30938464
  4. Formic acid up-regulates vascular tension through nitric oxide-cGMP signaling pathway.  |  Zhang, Q., et al. 2019. Chem Biol Interact. 309: 108710. PMID: 31199930
  5. Concentrations of Formic Acid, Acetic Acid, and Ammonia in Newly Constructed Houses.  |  Suzuki, N., et al. 2020. Int J Environ Res Public Health. 17: PMID: 32188069
  6. A Review of the Effect of Formic Acid and Its Salts on the Gastrointestinal Microbiota and Performance of Pigs.  |  Luise, D., et al. 2020. Animals (Basel). 10: PMID: 32438743
  7. Formic Acid as an Antimicrobial for Poultry Production: A Review.  |  Ricke, SC., et al. 2020. Front Vet Sci. 7: 563. PMID: 33088825
  8. Atomistic insights into heterogeneous reaction of formic acid on mineral oxide particles.  |  Yuan, S., et al. 2022. Chemosphere. 287: 132430. PMID: 34600931
  9. Transcriptomic analysis of formic acid stress response in Saccharomyces cerevisiae.  |  Zeng, L., et al. 2022. World J Microbiol Biotechnol. 38: 34. PMID: 34989900
  10. Effects of methanol and formic acid on CRYB, ALDH2, and ATP5A1 of RGCs.  |  Liu, D., et al. 2022. Cutan Ocul Toxicol. 41: 221-225. PMID: 35696782
  11. Mechanistic insights to lactic and formic acid toxicity on benthic oligochaete worm Tubifex tubifex.  |  Garai, P., et al. 2022. Environ Sci Pollut Res Int. 29: 87319-87333. PMID: 35802337
  12. Electrochemical Upgrading of Formic Acid to Formamide via Coupling Nitrite Co-Reduction.  |  Guo, C., et al. 2022. J Am Chem Soc. 144: 16006-16011. PMID: 35905476
  13. Selective Oxidation of Glycerol into Formic Acid by Photogenerated Holes and Superoxide Radicals.  |  Liu, M., et al. 2022. ChemSusChem. 15: e202201068. PMID: 35916074
  14. Systematic evaluation of urinary formic acid as a new potential biomarker for Alzheimer's disease.  |  Wang, Y., et al. 2022. Front Aging Neurosci. 14: 1046066. PMID: 36533170

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Formic acid, 5 ml

sc-215055
5 ml
$82.00

Formic acid, 100 ml

sc-215055A
100 ml
$112.00