Date published: 2025-10-3

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Ethyl 3,4-Dihydroxycinnamate (CAS 66648-50-8)

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Alternate Names:
Caffeic acid ethyl ester; CAEE; Ethyl caffeate
CAS Number:
66648-50-8
Purity:
≥99%
Molecular Weight:
208.2
Molecular Formula:
C11H12O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Ethyl 3,4-Dihydroxycinnamate shows anti-inflammatory, immunomodulatory, and anti-carcinogenic properties. Ethyl 3,4-Dihydroxycinnamate suppresses lipopolysaccharide (LPS)-induced nitric oxide (NO) production. Ethyl 3,4-Dihydroxycinnamate is a potent and specific inhibitor of NF-κB and its downstream inflammatory mediators: NOS2 (inducible nitric oxide synthase; NOS; NOS II), Cox-2 (cyclooxygenase-2), and prostaglandin E2 (PGE2). Ethyl 3,4-Dihydroxycinnamate prevents DNA single-strand breaks caused by H2O2.


Ethyl 3,4-Dihydroxycinnamate (CAS 66648-50-8) References

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  2. Ethyl caffeate suppresses NF-kappaB activation and its downstream inflammatory mediators, iNOS, COX-2, and PGE2 in vitro or in mouse skin.  |  Chiang, YM., et al. 2005. Br J Pharmacol. 146: 352-63. PMID: 16041399
  3. Antitumor activity of some natural flavonoids and synthetic derivatives on various human and murine cancer cell lines.  |  Cárdenas, M., et al. 2006. Bioorg Med Chem. 14: 2966-71. PMID: 16412650
  4. Highly efficient preparation of lipophilic hydroxycinnamates by solvent-free lipase-catalyzed transesterification.  |  Weitkamp, P., et al. 2006. J Agric Food Chem. 54: 7062-8. PMID: 16968063
  5. Drastic effect of several caffeic acid derivatives on the induction of heme oxygenase-1 expression revealed by quantitative real-time RT-PCR.  |  Suzuki, K., et al. 2006. Biofactors. 28: 151-8. PMID: 17473375
  6. Dispersion behavior of zirconia nanocrystals and their surface functionalization with vinyl group-containing ligands.  |  Zhou, S., et al. 2007. Langmuir. 23: 9178-87. PMID: 17663571
  7. Lead optimization studies of cinnamic amide EP2 antagonists.  |  Ganesh, T., et al. 2014. J Med Chem. 57: 4173-84. PMID: 24773616
  8. (R)-(+)-α-lipoic acid protected NG108-15 cells against H₂O₂-induced cell death through PI3K-Akt/GSK-3β pathway and suppression of NF-κβ-cytokines.  |  Kamarudin, MN., et al. 2014. Drug Des Devel Ther. 8: 1765-80. PMID: 25336920
  9. Curcumenol isolated from Curcuma zedoaria suppresses Akt-mediated NF-κB activation and p38 MAPK signaling pathway in LPS-stimulated BV-2 microglial cells.  |  Lo, JY., et al. 2015. Food Funct. 6: 3550-9. PMID: 26301513
  10. Anti-neuroinflammatory Activity of Elephantopus scaber L. via Activation of Nrf2/HO-1 Signaling and Inhibition of p38 MAPK Pathway in LPS-Induced Microglia BV-2 Cells.  |  Chan, CK., et al. 2017. Front Pharmacol. 8: 397. PMID: 28680404
  11. Antibacterial Properties of Polyphenols: Characterization and QSAR (Quantitative Structure-Activity Relationship) Models.  |  Bouarab-Chibane, L., et al. 2019. Front Microbiol. 10: 829. PMID: 31057527
  12. Phytochemical Profiling and Biological Potential of Prunus dulcis Shell Extracts.  |  Ben Khadher, T., et al. 2023. Plants (Basel). 12: PMID: 37514346
  13. [15-year-long observations after combined radiotherapy of cervix cancer].  |  Kolesnikova, VA. 1977. Vopr Onkol. 23: 71-2. PMID: 906398

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Ethyl 3,4-Dihydroxycinnamate, 25 mg

sc-205930
25 mg
$51.00

Ethyl 3,4-Dihydroxycinnamate, 250 mg

sc-205930A
250 mg
$360.00