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Dihydrolanosterol (CAS 79-62-9)

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Alternate Names:
(3β)-Lanost-8-en-3-ol; 5α-Lanost-8-en-3β-ol; Lanost-8-en-3β-ol; 24,25-Dihydrolanosterol
CAS Number:
79-62-9
Molecular Weight:
428.73
Molecular Formula:
C30H52O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Dihydrolanosterol, a compound that has drawn the attention of researchers in the field of lipid biochemistry. This intriguing chemical entity, derived from lanosterol, has been the subject of investigation to unravel its role in cellular processes and lipid metabolism. Researchers have conducted studies to understand the biosynthesis and transformations of Dihydrolanosterol, aiming to elucidate its functions and potential implications for human health. Investigations have focused on its involvement in cholesterol synthesis and its relationship to various lipid-related disorders. Additionally, researchers have explored its interactions with enzymes and cellular membranes, shedding light on its potential physiological functions. The research on Dihydrolanosterol advances our understanding of lipid biochemistry and its significance in maintaining cellular homeostasis, providing valuable insights into the intricate world of lipid metabolism within the human body.


Dihydrolanosterol (CAS 79-62-9) References

  1. The lymphatic absorption of dihydrolanosterol and cholesterol in the rat.  |  Satchithanandam, S., et al. 1999. Res Commun Mol Pathol Pharmacol. 103: 91-100. PMID: 10440574
  2. Aspergillus oryzae produces compounds inhibiting cholesterol biosynthesis downstream of dihydrolanosterol.  |  Hajjaj, H., et al. 2005. FEMS Microbiol Lett. 242: 155-9. PMID: 15621432
  3. Structural complex of sterol 14α-demethylase (CYP51) with 14α-methylenecyclopropyl-Delta7-24, 25-dihydrolanosterol.  |  Hargrove, TY., et al. 2012. J Lipid Res. 53: 311-20. PMID: 22135275
  4. Metabolism of 24,25-dihydrolanosterol analogs by partially purified cytochrome P-450(14DM) from rat liver microsomes.  |  Sonoda, Y., et al. 1989. Chem Pharm Bull (Tokyo). 37: 718-22. PMID: 2752483
  5. Separation and purification of lanosterol, dihydrolanosterol, and cholesterol from lanolin by high-performance counter-current chromatography dual-mode elution method.  |  Pei, H., et al. 2019. J Sep Sci. 42: 2171-2178. PMID: 30950563
  6. Efferocytosis potentiates the expression of arachidonate 15-lipoxygenase (ALOX15) in alternatively activated human macrophages through LXR activation.  |  Snodgrass, RG., et al. 2021. Cell Death Differ. 28: 1301-1316. PMID: 33177619
  7. 7-Oxo-24,25-dihydrolanosterol: a novel lanosterol 14 alpha-demethylase (P-45014DM) inhibitor which blocks electron transfer to the oxyferro intermediate.  |  Aoyama, Y., et al. 1987. Biochim Biophys Acta. 922: 270-7. PMID: 3318933
  8. Solanum alkaloids as inhibitors of enzymatic conversion of dihydrolanosterol into cholesterol.  |  Kusano, G., et al. 1987. Chem Pharm Bull (Tokyo). 35: 4321-3. PMID: 3435956
  9. Metabolism of 32-hydroxy-24,25-dihydrolanosterol by purified cytochrome P-45014DM from yeast. Evidence for contribution of the cytochrome to whole process of lanosterol 14 alpha-demethylation.  |  Aoyama, Y., et al. 1987. J Biol Chem. 262: 1239-43. PMID: 3543000
  10. Squalene through Its Post-Squalene Metabolites Is a Modulator of Hepatic Transcriptome in Rabbits.  |  Abuobeid, R., et al. 2022. Int J Mol Sci. 23: PMID: 35456988
  11. Isolation of lanosterol and dihydrolanosterol from the unsaponifiable matter of lanolin by urea complexation and countercurrent chromatography in heart-cut recycling mode.  |  Rüttler, F., et al. 2022. J Chromatogr B Analyt Technol Biomed Life Sci. 1210: 123470. PMID: 36191441
  12. Oxygenated sterols as inhibitors of enzymatic conversion of dihydrolanosterol into cholesterol.  |  Sato, Y., et al. 1984. Chem Pharm Bull (Tokyo). 32: 3305-8. PMID: 6518607
  13. Detection and quantification of lanosterol and dihydrolanosterol esters by measurements of metastable decompositions. Application to their direct analysis in wool wax.  |  Patouraux, D., et al. 1981. Biomed Mass Spectrom. 8: 118-21. PMID: 6894557

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Dihydrolanosterol, 100 mg

sc-498531
100 mg
$350.00

Dihydrolanosterol, 1 g

sc-498531A
1 g
$2450.00