Dihydrocapsaicin (CAS 19408-84-5)
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Dihydrocapsaicin is isolated from Capsicum fruit. Capsaicin is the primary active component of the heat and pain-eliciting lipid soluble fraction of the Capsicum pepper. Like capsaicin, dihydrocapsaicin is an irritant. Capsaicin is found in natural hot pepper extracts along with a number of impurities, including dihydrocapsaicin and several lesser impurities. Separation by HPLC is required in order to obtain pure dihydrocapsaicin. Dihydrocapsaicin represents about 10% of the compound present in commercial preparations purporting to be pure capsaicin, but it has about the same pungency as capsaicin. VR1 (vanilloid receptor 1) is a heat activated calcium ion channel which functions as a part of the normal nociceptive pain pathway. Capsaicin elicits a sensation of burning pain by activation of VR1 on small, non-myelinated polymodal C-type nociceptive nerve fibers. The potency of dihydrocapsaicin at VR1 appears equivalent to capsaicin. Antioxidant. Reduces oxidation of serum lipids. Mutagenic. Dihydrocapsaicin is an activator of VR1.
Dihydrocapsaicin (CAS 19408-84-5) References
- Determination of capsaicin and dihydrocapsaicin by micellar electrokinetic capillary chromatography and its application to various species of Capsicum, Solanaceae. | Laskaridou-Monnerville, A. 1999. J Chromatogr A. 838: 293-302. PMID: 10327645
- Dihydrocapsaicin treatment depletes peptidergic nerve fibers of substance P and alters mast cell density in the respiratory tract of neonatal sheep. | Ramírez-Romero, R., et al. 2000. Regul Pept. 91: 97-106. PMID: 10967206
- Oxidative DNA damage by capsaicin and dihydrocapsaicin in the presence of Cu(II). | Singh, S., et al. 2001. Cancer Lett. 169: 139-46. PMID: 11431102
- Effects of capsaicin, dihydrocapsaicin, and curcumin on copper-induced oxidation of human serum lipids. | Ahuja, KD., et al. 2006. J Agric Food Chem. 54: 6436-9. PMID: 16910741
- Determination of capsaicin and dihydrocapsaicin in capsicum fruits by liquid chromatography-electrospray/time-of-flight mass spectrometry. | Garcés-Claver, A., et al. 2006. J Agric Food Chem. 54: 9303-11. PMID: 17147411
- Inheritance of capsaicin and dihydrocapsaicin, determined by HPLC-ESI/MS, in an intraspecific cross of Capsicum annuum L. | Garcés-Claver, A., et al. 2007. J Agric Food Chem. 55: 6951-7. PMID: 17661486
- Dihydrocapsaicin (DHC), a saturated structural analog of capsaicin, induces autophagy in human cancer cells in a catalase-regulated manner. | Oh, SH., et al. 2008. Autophagy. 4: 1009-19. PMID: 18818525
- Analysis of capsaicin and dihydrocapsaicin in peppers and pepper sauces by solid phase microextraction-gas chromatography-mass spectrometry. | Peña-Alvarez, A., et al. 2009. J Chromatogr A. 1216: 2843-7. PMID: 19100557
- Effect of capsaicin and dihydrocapsaicin on in vitro blood coagulation and platelet aggregation. | Adams, MJ., et al. 2009. Thromb Res. 124: 721-3. PMID: 19476975
- Determination of capsaicin and dihydrocapsaicin in Capsicum fruit samples using high performance liquid chromatography. | Al Othman, ZA., et al. 2011. Molecules. 16: 8919-29. PMID: 22024959
- Electrochemical evaluation and adsorptive stripping voltammetric determination of capsaicin or dihydrocapsaicin on a disposable pencil graphite electrode. | Yardım, Y. and Sentürk, Z. 2013. Talanta. 112: 11-9. PMID: 23708530
- Capsaicin and dihydrocapsaicin determination in chili pepper genotypes using ultra-fast liquid chromatography. | Usman, MG., et al. 2014. Molecules. 19: 6474-88. PMID: 24853712
- The mutagenicity of capsaicin and dihydrocapsaicin in V79 cells. | Lawson, T. and Gannett, P. 1989. Cancer Lett. 48: 109-13. PMID: 2684392
- Gastrointestinal absorption and metabolism of capsaicin and dihydrocapsaicin in rats. | Kawada, T., et al. 1984. Toxicol Appl Pharmacol. 72: 449-56. PMID: 6710495
- The capsaicin receptor: a heat-activated ion channel in the pain pathway. | Caterina, MJ., et al. 1997. Nature. 389: 816-24. PMID: 9349813
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dihydrocapsaicin, 10 mg | sc-202578 | 10 mg | $51.00 | |||
Dihydrocapsaicin, 50 mg | sc-202578A | 50 mg | $153.00 |