Diethylmaleate (CAS 141-05-9)
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Diethylmaleate is a compound that functions as a chemical modifier in experimental applications. It acts as a cross-linking agent, forming covalent bonds with thiol groups in proteins and peptides. This modification can be utilized to study the structure and function of proteins, as well as to investigate protein-protein interactions. Diethylmaleate′s mechanism of action involves the disruption of disulfide bonds, leading to conformational changes in proteins and altering their activity. Diethylmaleate can be used to manipulate the redox state of proteins and investigate the role of thiol groups in various biological processes. Diethylmaleate has been to study the effects of oxidative stress on cellular function, as it can induce changes in the redox status of cells. Its ability to modify thiol groups may be a useful for probing the role of these functional groups in biological systems.
Diethylmaleate (CAS 141-05-9) References
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- Transcriptional and physiological responses of HepG2 cells exposed to diethyl maleate: time course analysis. | Casey, W., et al. 2002. Physiol Genomics. 8: 115-22. PMID: 11875189
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- Increase in endothelial cell glutathione and precursor amino acid uptake by diethyl maleate and hyperoxia. | Deneke, SM., et al. 1989. Am J Physiol. 257: L265-71. PMID: 2801955
- Erythrocytes fail to induce glutathione in response to diethyl maleate or hyperoxia. | Phelps, DT., et al. 1989. Am J Physiol. 257: L272-6. PMID: 2801956
- Nuclear trapping of inactive FOXO1 by the Nrf2 activator diethyl maleate. | Gille, A., et al. 2019. Redox Biol. 20: 19-27. PMID: 30261343
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- The effect on the Km for radiosensitization at 0 degree C of thiol depletion by diethylmaleate pretreatment: quantitative differences found using the radiation sensitizing agent misonidazole or oxygen. | Koch, CJ., et al. 1984. Radiat Res. 98: 141-53. PMID: 6718689
- Effect of fasting, diethyl maleate, and alcohols on carbon tetrachloride-induced hepatotoxicity. | Harris, RN. and Anders, MW. 1980. Toxicol Appl Pharmacol. 56: 191-8. PMID: 7466818
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Diethylmaleate, 5 g | sc-202577 | 5 g | $26.00 |