Molecular structure of Diallyl sulfide, CAS Number: 592-88-1
Diallyl sulfide (CAS 592-88-1)
See product citations (3)
Alternate Names:
Allyl sulfide; garlic oil
Application:
Diallyl sulfide is an anticarcinogenic thioester compound isolated from garlic
CAS Number:
592-88-1
Purity:
≥95%
Molecular Weight:
114.21
Molecular Formula:
C6H10S
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Diallyl sulfide, a sulfur-containing organic compound, is utilized in research focused on its antioxidative properties and its ability to induce the phase II detoxification enzyme system. Studies often explore its role in promoting the production of enzymes such as glutathione S-transferase, which is significant in cellular detoxification processes. Researchers have also investigated diallyl sulfide for its potential in influencing the metabolism of various xenobiotics by modulating cytochrome P450 enzymes. In addition, its interaction with reactive oxygen species and its impact on oxidative stress parameters in cellular models are areas of interest. Diallyl sulfide is studied for its effects on gene expression regulation, particularly genes involved in antioxidant defenses and metabolic pathways.
Diallyl sulfide (CAS 592-88-1) References
- Diallyl sulfide enhances azoxymethane-induced preneoplasia in Fischer 344 rat colon. | Delker, DA., et al. 2000. Chem Biol Interact. 124: 149-60. PMID: 10728775
- Diallyl sulfide inhibits diethylstilbestrol induced DNA damage in human breast epithelial cells (MCF-10A). | McCaskill, ML., et al. 2014. Steroids. 92: 96-100. PMID: 25278253
- Diallyl sulfide alleviates cisplatin-induced nephrotoxicity in rats via suppressing NF-κB downstream inflammatory proteins and p53/Puma signalling pathway. | Elkhoely, A. and Kamel, R. 2018. Clin Exp Pharmacol Physiol. 45: 591-601. PMID: 29266336
- Diallyl sulfide protects against lipopolysaccharide/d-galactosamine-induced acute liver injury by inhibiting oxidative stress, inflammation and apoptosis in mice. | Li, M., et al. 2018. Food Chem Toxicol. 120: 500-509. PMID: 30075314
- Diallyl sulfide ameliorates carbon tetrachloride-induced hepatotoxicity in rats via suppressing stress-activated MAPK signaling pathways. | Elkhoely, A. 2019. J Biochem Mol Toxicol. 33: e22307. PMID: 30811752
- Diallyl sulfide alleviates cyclophosphamide-induced nephropathic encephalopathy in rats. | Galal, SM., et al. 2020. Toxicol Mech Methods. 30: 208-218. PMID: 31779506
- Diallyl sulfide-induced attenuation of n-hexane-induced peripheral nerve impairment is associated with metabolic inhibition of n-hexane. | Li, X., et al. 2020. Food Chem Toxicol. 137: 111167. PMID: 32007468
- Immunomodulatory effect of diallyl sulfide on experimentally-induced benign prostate hyperplasia via the suppression of CD4+T/IL-17 and TGF-β1/ERK pathways. | Elbaz, EM., et al. 2020. Inflammopharmacology. 28: 1407-1420. PMID: 32785828
- Relaxant effect of diallyl sulfide on nonpregnant rat uterus: Involvement of voltage-dependent calcium channels. | Efe, OE., et al. 2021. J Obstet Gynaecol Res. 47: 88-95. PMID: 32830389
- Diallyl Sulfide-Mediated Modulation of the Fatty Acid Synthase (FASN) Leads to Cancer Cell Death in BaP-Induced Lung Carcinogenesis in Swiss Mice. | Khan, A., et al. 2020. J Inflamm Res. 13: 1075-1087. PMID: 33324084
- Diallyl sulfide from garlic suppresses quorum-sensing systems of Pseudomonas aeruginosa and enhances biosynthesis of three B vitamins through its thioether group. | Li, WR., et al. 2021. Microb Biotechnol. 14: 677-691. PMID: 33377615
- Diallyl Sulfide Attenuation of Carcinogenesis in Mammary Epithelial Cells through the Inhibition of ROS Formation, and DNA Strand Breaks. | Darling-Reed, SF., et al. 2021. Biomolecules. 11: PMID: 34572526
- Diallyl sulfide protects against dilated cardiomyopathy via inhibition of oxidative stress and apoptosis in mice. | Pang, S., et al. 2021. Mol Med Rep. 24: PMID: 34651661
- Estrogen receptor-α36 is involved in diallyl sulfide-induced inhibition of malignant growth of HepG2 and Huh7 hepatocellular carcinoma cells. | Wu, W., et al. 2022. Environ Toxicol. 37: 270-281. PMID: 34724321
- [The protective effects of diallyl sulfide (DAS) on genotoxicity induced by benzene]. | Yu, T., et al. 2022. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 40: 568-572. PMID: 36052584
Inhibitor of:
4732456N10Rik, Aflatoxin B1, CYP2E1, GASP-2, GSTA, HNF-6, Keratin 17, MATP, PLP, and Spot 14.Activator of:
AKR7, ALDH1B1, ALDH3A1, Antiquitin, CYP2A7, CYP2C19, Glutathione reductase, Gm766, GST, GSTA3, GSTA4, GSTA5, GSTT1, GSTT2B, GSTT4, HLTF, Keap1, KIAA0754, LOC100040722, MGST3, NAT-13, Olfr701, Olfr770, Olfr876, P15RS, PON1, SULT1, SULT1A2, SULT1B1, UGT1A9, and UGT2B37.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Diallyl sulfide, 25 g | sc-204718 | 25 g | $41.00 | |||
Diallyl sulfide, 100 g | sc-204718A | 100 g | $104.00 |