Molecular structure of Deoxyschizandrin, CAS Number: 61281-37-6
Deoxyschizandrin (CAS 61281-38-7)
Alternate Names:
Schizandrin A
Application:
Deoxyschizandrin is an agonist of the adiponectin receptor 2 (AdipoR2)
CAS Number:
61281-38-7
Molecular Weight:
416.51
Molecular Formula:
C24H32O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Deoxyschizandrin is a bio-active isolate of Schisandra chinensis that has been found to act as an agonist of the adiponectin receptor 2 (AdipoR2). Studies have suggested that deoxyschizandrin may have cardioprotective effects related to their role in inhibiting cardiomyocyte apoptosis. Deoxyschizandrin activity on AdipoR2 may be useful in the suppression of metabolic disorders that can result in type 2 diabetes, obesity, and atherosclerosis. Up-regulation of adiponectin or adiponectin receptor has a number of therapeutic benefits whereby deoxyschizandrin and similar compounds may be useful drug candidates for hypoadiponectin related diseases.
Deoxyschizandrin (CAS 61281-38-7) References
- Molecular mechanism of apoptosis induced by schizandrae-derived lignans in human leukemia HL-60 cells. | Lin, S., et al. 2008. Food Chem Toxicol. 46: 590-7. PMID: 17950515
- Determination of deoxyschizandrin in rat plasma by LC-MS. | Deng, X., et al. 2008. J Pharm Biomed Anal. 46: 121-6. PMID: 18022778
- A concise total synthesis of deoxyschizandrin and exploration of its antiproliferative effects and those of structurally related derivatives. | Zheng, S., et al. 2012. Chemistry. 18: 3193-8. PMID: 22307955
- Protective role of deoxyschizandrin and schisantherin A against myocardial ischemia-reperfusion injury in rats. | Chang, R., et al. 2013. PLoS One. 8: e61590. PMID: 23620773
- Identification of adiponectin receptor agonist utilizing a fluorescence polarization based high throughput assay. | Sun, Y., et al. 2013. PLoS One. 8: e63354. PMID: 23691032
- Effects of piperine and deoxyschizandrin on synchronized Ca²⁺ oscillations in cultured hippocampal neuronal cells. | Zhang, S., et al. 2013. Eur Biophys J. 42: 673-82. PMID: 23771746
- Deoxyschizandrin, a naturally occurring lignan, is a specific probe substrate of human cytochrome P450 3A. | Wu, J., et al. 2014. Drug Metab Dispos. 42: 94-104. PMID: 24131672
- Identification of metabolites of deoxyschizandrin in rats by UPLC-Q-TOF-MS/MS based on multiple mass defect filter data acquisition and multiple data processing techniques. | Liu, M., et al. 2014. J Chromatogr B Analyt Technol Biomed Life Sci. 949-950: 115-26. PMID: 24487041
- Optimization of vinegar-steaming process for Wuweizi (Fructus Schisandrae Chinensis) with response surface method. | Zhang, Y., et al. 2013. J Tradit Chin Med. 33: 682-5. PMID: 24660596
- Deoxyschizandrin suppresses dss-induced ulcerative colitis in mice. | Zhang, WF., et al. 2016. Saudi J Gastroenterol. 22: 448-455. PMID: 27976641
- Study on the pharmacokinetics of deoxyschizandrin and schizandrin in combination with epigallocatechin gallate, a component of green tea, in rats. | Liu, Y., et al. 2018. Xenobiotica. 48: 412-421. PMID: 28471331
- Interaction of deoxyschizandrin and schizandrin B with liver uptake transporters OATP1B1 and OATP1B3. | Lu, Y., et al. 2019. Xenobiotica. 49: 239-246. PMID: 29405807
- Deoxyschizandrin Loaded Liposomes on the Suppression Lipid Accumulation in 3T3-L1 Adipocytes. | Liu, X., et al. 2018. Molecules. 23: PMID: 30150602
- Deoxyschizandrin treats mice with ulcerative colitis possibly via the TLR4/NF-κB signaling pathway. | Yu, S. and Qian, H. 2021. Am J Transl Res. 13: 3856-3863. PMID: 34017577
- Deoxyschizandrin Inhibits the Proliferation, Migration, and Invasion of Bladder Cancer Cells through ALOX5 Regulating PI3K-AKT Signaling Pathway. | Chi, B., et al. 2022. J Immunol Res. 2022: 3079823. PMID: 35664354
Inhibitor of:
FK-506, GADD 45α, Mec1, and Rad50.Activator of:
AdipoR2, Integrin αL, and MTBP.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Deoxyschizandrin, 10 mg | sc-278925 | 10 mg | $80.00 |