Dengue Virus Antibody (D1-11): sc-65659

Dengue Virus Antibody (D1-11) is a mouse monoclonal IgG2a antibody that detects Dengue Virus protein from Dengue Virus 1, 2, 3, and 4 origin by western blotting (WB), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). Dengue Virus (D1-11) antibody is available in a non-conjugated form, providing researchers with a versatile tool for studying this significant pathogen. Dengue Virus, a member of the genus Flavivirus and family Flaviviridae, is responsible for causing Dengue fever, an acute febrile illness prevalent in tropical regions. The virus is transmitted to humans primarily through mosquito bites, leading to symptoms such as high fever, severe headaches, muscle and joint pain, and rashes, typically lasting six to seven days. The genome of Dengue Virus is a single-stranded positive-sense RNA that encodes three structural proteins—capsid, membrane, and envelope—as well as seven nonstructural proteins, which play crucial roles in the virus′s life cycle and pathogenesis. Notably, the envelope protein is essential for viral entry into host cells, as it facilitates the fusion of the viral and cellular membranes. Understanding the structure and function of these proteins is vital for developing effective vaccines and therapeutics against Dengue fever, as they are key targets for neutralizing antibodies and antiviral strategies. With detection capabilities across all four serotypes, Dengue Virus (D1-11) monoclonal antibody serves as an invaluable resource for researchers investigating the complexities of Dengue virus infections and their impact on public health.

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Dengue Virus Antibody (D1-11) References:

1. Dengue virus type 1 nonstructural glycoprotein NS1 is secreted from mammalian cells as a soluble hexamer in a glycosylation-dependent fashion.  |  Flamand, M., et al. 1999. J Virol. 73: 6104-10. PMID: 10364366
2. Structure of dengue virus: implications for flavivirus organization, maturation, and fusion.  |  Kuhn, RJ., et al. 2002. Cell. 108: 717-25. PMID: 11893341
3. Diversity and evolution of the envelope gene of dengue virus type 1.  |  Goncalvez, AP., et al. 2002. Virology. 303: 110-9. PMID: 12482662
4. Molecular epidemiological study of dengue virus type 1 in Taiwan.  |  Hwang, KP., et al. 2003. J Med Virol. 70: 404-9. PMID: 12767004
5. Brazilian dengue virus type 1 replication in mosquito cell cultures.  |  Barth, OM. and Schatzmayr, HG. 1992. Mem Inst Oswaldo Cruz. 87: 1-7. PMID: 1308543
6. Cultivation of mouse-adapted dengue virus (type 1) in rhesus monkey tissue culture.  |  HOTTA, S. and EVANS, CA. 1956. J Infect Dis. 98: 88-97. PMID: 13295630
7. Molecular analysis of the dengue virus type 1 and 2 in Brazil based on sequences of the genomic envelope-nonstructural protein 1 junction region.  |  Santos, CL., et al. 2004. Rev Inst Med Trop Sao Paulo. 46: 145-52. PMID: 15286818
8. Use of a short fragment of the C-terminal E gene for detection and characterization of two new lineages of dengue virus 1 in India.  |  Domingo, C., et al. 2006. J Clin Microbiol. 44: 1519-29. PMID: 16597885
9. Molecular Mechanisms of Antiviral Agents against Dengue Virus.  |  Lee, MF., et al. 2023. Viruses. 15: PMID: 36992414
10. Dengue virus pathogenesis and host molecular machineries.  |  Sinha, S., et al. 2024. J Biomed Sci. 31: 43. PMID: 38649998
11. A serotype-specific epitope of dengue virus 1 identified by phage displayed random peptide library.  |  Yao, ZJ., et al. 1995. FEMS Microbiol Lett. 127: 93-8. PMID: 7537702
12. Isolation of dengue virus type 1 from larvae of Aedes albopictus in Campos Altos city, State of Minas Gerais, Brazil.  |  Serufo, JC., et al. 1993. Mem Inst Oswaldo Cruz. 88: 503-4. PMID: 8107613

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Dengue Virus Antibody (D1-11) has 13 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Dengue Virus Antibody (D1-11) Specifications

Alternate Product Name: Dengue Virus

Product Clone Name: D1-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a

Amino Acids:

Epitope Target: Dengue Virus

Epitope Species: Dengue virus

Product Reactivity/Detection: Dengue Virus 1, 2, 3 and 4

Species Reactivity/Detection: Dengue Virus 1, 2, 3, and 4

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IF, IHC(P)

Vialing Information: Each vial contains 100 µg IgG_2a in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 13 citations in various scientific publications

Available Conjugates/Forms for Dengue Virus Antibody (D1-11): N/A