Molecular structure of Deflazacort, CAS Number: 14484-47-0
Deflazacort (CAS 14484-47-0)
Application:
Deflazacort is a systemic corticosteroid
CAS Number:
14484-47-0
Purity:
≥97%
Molecular Weight:
441.52
Molecular Formula:
C25H31NO6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Deflazacort is a glucocorticoid with anti-inflammatory and immunosuppressive properties. Deflazacort functions by binding to the cytoplasmic glucocorticoid receptor, leading to the formation of a receptor-ligand complex. This complex then translocates into the nucleus, where it modulates gene expression by binding to glucocorticoid response elements in the promoter region of target genes. This results in the upregulation of anti-inflammatory proteins and the downregulation of pro-inflammatory proteins, ultimately reducing the inflammatory response. Deflazacort inhibits the production of pro-inflammatory cytokines and enzymes, further contributing to its anti-inflammatory effects.
Deflazacort (CAS 14484-47-0) References
- Deflazacort increases laminin expression and myogenic repair, and induces early persistent functional gain in mdx mouse muscular dystrophy. | Anderson, JE., et al. 2000. Cell Transplant. 9: 551-64. PMID: 11038071
- Deflazacort treatment of Duchenne muscular dystrophy. | Biggar, WD., et al. 2001. J Pediatr. 138: 45-50. PMID: 11148511
- Deflazacort induced stronger immunosuppression than expected. | Gonzalez-Castañeda, RE., et al. 2007. Clin Rheumatol. 26: 935-40. PMID: 16738843
- Deflazacort versus other glucocorticoids: a comparison. | Nayak, S. and Acharjya, B. 2008. Indian J Dermatol. 53: 167-70. PMID: 19882026
- Deflazacort in comparison to other steroids for nephrotic syndrome. | Jat, KR. and Khairwa, A. 2012. Indian J Nephrol. 22: 239-45. PMID: 23162265
- The impact of deflazacort on puberty in Duchenne muscular dystrophy. | Dooley, JM., et al. 2013. Pediatr Neurol. 49: 292-3. PMID: 23921283
- Deflazacort Versus Prednisolone: Randomized Controlled Trial in Treatment of Children With Idiopathic Nephrotic Syndrome. | Singhal, R., et al. 2015. Iran J Pediatr. 25: e510. PMID: 26196009
- Pharmacokinetics of deflazacort in rabbits after intravenous and oral administration and its interaction with erythromycin. | Escudero, AI., et al. 2018. J Vet Pharmacol Ther. 41: e10-e15. PMID: 28741668
- Deflazacort-induced Acneiform Eruptions. | Bashir, MSM., et al. 2017. J Pharm Bioallied Sci. 9: 284-286. PMID: 29456382
- Skeletal Muscle Response to Deflazacort, Dexamethasone and Methylprednisolone. | Fappi, A., et al. 2019. Cells. 8: PMID: 31052442
- Deflazacort vs prednisone treatment for Duchenne muscular dystrophy: A meta-analysis of disease progression rates in recent multicenter clinical trials. | McDonald, CM., et al. 2020. Muscle Nerve. 61: 26-35. PMID: 31599456
- The Effect of Deflazacort Treatment on the Functioning of Skeletal Muscle Mitochondria in Duchenne Muscular Dystrophy. | Dubinin, MV., et al. 2020. Int J Mol Sci. 21: PMID: 33228255
- Anti-Inflammatory Effect of Deflazacort. | Stellato, C., et al. 1992. Int Arch Allergy Immunol. 99: 340-342. PMID: 34167210
- Meta-analyses of deflazacort versus prednisone/prednisolone in patients with nonsense mutation Duchenne muscular dystrophy. | Shieh, PB., et al. 2021. J Comp Eff Res. 10: 1337-1347. PMID: 34693725
- Expeditious synthesis and preliminary antimicrobial activity of deflazacort and its precursors. | Esposito, A., et al. 2019. RSC Adv. 9: 21519-21524. PMID: 35521350
Inhibitor of:
δ-sarcoglycan, and Dystrophin-Glycoprotein Complex (DGC; Sarcospan).Activator of:
dystrophin, FRG1B, and Med18.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Deflazacort, 25 mg | sc-204709C | 25 mg | $60.00 | |||
Deflazacort, 100 mg | sc-204709 | 100 mg | $190.00 | |||
Deflazacort, 250 mg | sc-204709A | 250 mg | $310.00 | |||
Deflazacort, 1 g | sc-204709B | 1 g | $1000.00 |