Date published: 2025-10-14

1-800-457-3801

SCBT Portrait Logo
Seach Input

D-Threitol (CAS 2418-52-2)

0.0(0)
Write a reviewAsk a question

Alternate Names:
(2R,3R)-butane-1,2,3,4-tetrol
Application:
D-Threitol is a chiral tetrol used in a variety of synthesis reactions
CAS Number:
2418-52-2
Molecular Weight:
122.12
Molecular Formula:
C4H10O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

D-Threitol, a four-carbon sugar alcohol, is a versatile compound utilized extensively in research applications that span from organic synthesis to molecular biology. In the realm of synthetic chemistry, D-Threitol serves as a chiral building block for the construction of more complex molecules, allowing researchers to probe the stereochemical aspects of chemical reactions and pathways. Its symmetrical structure and multiple hydroxyl groups make it an ideal candidate for studying protecting group strategies and polyol derivatization. In the study of biological systems, D-Threitol is used as a component in buffer solutions to stabilize proteins and enzymes, which is for maintaining their activity during analytical procedures. Additionally, it is employed as a calibration standard in chromatographic methods due to its well-defined physicochemical properties, thereby aiding in the quantification of substances in complex mixtures.


D-Threitol (CAS 2418-52-2) References

  1. The crystal structure of D-threitol at 119 K and 198 K.  |  Jeffrey, GA. and Huang, DB. 1992. Carbohydr Res. 223: 11-8. PMID: 1596913
  2. Sugar-alcohol complexes of palladium(II): on the variable rigidity of open-chain carbohydrate ligands.  |  Allscher, T., et al. 2007. Chem Asian J. 2: 1037-45. PMID: 17577890
  3. Aspergillusol A, an alpha-glucosidase inhibitor from the marine-derived fungus Aspergillus aculeatus.  |  Ingavat, N., et al. 2009. J Nat Prod. 72: 2049-52. PMID: 19824618
  4. A General Strategy for the Discovery of Metabolic Pathways: d-Threitol, l-Threitol, and Erythritol Utilization in Mycobacterium smegmatis.  |  Huang, H., et al. 2015. J Am Chem Soc. 137: 14570-3. PMID: 26560079
  5. Correction to 'A General Strategy for the Discovery of Metabolic Pathways: D-Threitol, L-Threitol, and Erythritol Utilization in Mycobacterium smegmatis'.  |  Huang, H., et al. 2016. J Am Chem Soc. 138: 4267. PMID: 26978037
  6. The urinary 1 H-NMR metabolomics profile of an italian autistic children population and their unaffected siblings.  |  Lussu, M., et al. 2017. Autism Res. 10: 1058-1066. PMID: 28296209
  7. Metabolites related to eGFR: Evaluation of candidate molecules for GFR estimation using untargeted metabolomics.  |  Titan, SM., et al. 2019. Clin Chim Acta. 489: 242-248. PMID: 30153452
  8. Comparative metabolomics implicates threitol as a fungal signal supporting colonization of Armillaria luteobubalina on eucalypt roots.  |  Wong, JW., et al. 2020. Plant Cell Environ. 43: 374-386. PMID: 31797388
  9. The Effect of Exogenous Free Nε-(Carboxymethyl)Lysine on Diabetic-Model Goto-Kakizaki Rats: Metabolomics Analysis in Serum and Urine.  |  Quan, W., et al. 2021. J Agric Food Chem. 69: 783-793. PMID: 33401897
  10. Metabolomic and Proteomic Analyses of Persistent Valvular Atrial Fibrillation and Non-Valvular Atrial Fibrillation.  |  Hu, B., et al. 2021. Front Genet. 12: 789485. PMID: 34917134
  11. Metabolomic Profiling of Peripheral Plasma by GC-MS and Correlation With Size of Uterine Leiomyomas.  |  Barison, GAS., et al. 2022. J Endocr Soc. 6: bvac061. PMID: 35611322
  12. Excretion of D-threitol after administration of D-xylose in man.  |  Pitkänen, E. and Svinhufvud, U. 1965. Ann Med Exp Biol Fenn. 43: 250-3. PMID: 5855592
  13. The conversion of D-xylose into D-threitol in patients without liver disease and in patients with portal liver cirrhosis.  |  Pitkänen, E. 1977. Clin Chim Acta. 80: 49-54. PMID: 908147

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

D-Threitol, 250 mg

sc-221522
250 mg
$143.00