Molecular structure of Cytochalasin H, CAS Number: 53760-19-3
Cytochalasin H (CAS 53760-19-3)
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Application:
Cytochalasin H is a cell-permeable fungal toxin used in actin polymerization studies and cytological research
CAS Number:
53760-19-3
Purity:
>95%
Molecular Weight:
493.6
Molecular Formula:
C30H39NO5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Cytochalasin H is used in actin polymerization studies. Cytochalasins are potent mycotoxins which bind to the barbed end of actin filaments resulting in inhibition of both the association and dissociation of subunits. Used as a tool for cytological research. These fungal toxins are related by their chemical structure characterized by a highly substituted hydrogenated isoindole ring to which is fused a macrocyclic ring. In vitro, cytochalasin H exhibits antibacterial, antifungal, nematocidal and antitumor activity.
Cytochalasin H (CAS 53760-19-3) References
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- Cytochalasin H, an active anti-angiogenic constituent of the ethanol extract of Gleditsia sinensis thorns. | Lee, J., et al. 2014. Biol Pharm Bull. 37: 6-12. PMID: 24172060
- A new cytochalasin from endophytic Phomopsis sp. IFB-E060. | Shen, L., et al. 2014. Chin J Nat Med. 12: 512-6. PMID: 25053550
- In Vivo Anti-tumor Effects of the Ethanol Extract of Gleditsia sinensis Thorns and Its Active Constituent, Cytochalasin H. | Yi, JM., et al. 2015. Biol Pharm Bull. 38: 909-12. PMID: 26027832
- Lethality of cytochalasin B and other compounds isolated from fungus Aspergillus sp. (Trichocomaceae) endophyte of Bauhinia guianensis (Fabaceae). | Feitosa, AO., et al. 2016. Rev Argent Microbiol. 48: 259-263. PMID: 27567521
- 18-Des-hydroxy Cytochalasin: an antiparasitic compound of Diaporthe phaseolorum-92C, an endophytic fungus isolated from Combretum lanceolatum Pohl ex Eichler. | Brissow, ER., et al. 2017. Parasitol Res. 116: 1823-1830. PMID: 28497228
- Cytochalasin H isolated from mangrove‑derived endophytic fungus induces apoptosis and inhibits migration in lung cancer cells. | Ma, Y., et al. 2018. Oncol Rep. 39: 2899-2905. PMID: 29620283
- Evaluation of Tumor Regulatory Genes and Apoptotic Pathways in The Cytotoxic Effect of Cytochalasin H on Malignant Human Glioma Cell Line (U87MG). | Heidarzadeh, S., et al. 2019. Cell J. 21: 62-69. PMID: 30507090
- New Cadinane Sesquiterpenes from the Stems of Kadsura heteroclita. | Cao, L., et al. 2019. Molecules. 24: PMID: 31035334
- Cytochalasin H Inhibits Angiogenesis via the Suppression of HIF-1α Protein Accumulation and VEGF Expression through PI3K/AKT/P70S6K and ERK1/2 Signaling Pathways in Non-Small Cell Lung Cancer Cells. | Ma, Y., et al. 2019. J Cancer. 10: 1997-2005. PMID: 31205560
- Effects of cytochalasin and phalloidin on actin. | Cooper, JA. 1987. J Cell Biol. 105: 1473-8. PMID: 3312229
- Cytochalasin H isolated from mangrove-derived endophytic fungus inhibits epithelial-mesenchymal transition and cancer stemness via YAP/TAZ signaling pathway in non-small cell lung cancer cells. | Xiu, Z., et al. 2021. J Cancer. 12: 1169-1178. PMID: 33442415
- Erratum: Cytochalasin H Inhibits Angiogenesis via the Suppression of HIF-1α Protein Accumulation and VEGF Expression through PI3K/AKT/P70S6K and ERK1/2 Signaling Pathways in Non-Small Cell Lung Cancer Cells: Erratum. | Ma, Y., et al. 2023. J Cancer. 14: 1157-1158. PMID: 37215451
- Erratum: Cytochalasin H isolated from mangrove-derived endophytic fungus inhibits epithelial-mesenchymal transition and cancer stemness via YAP/TAZ signaling pathway in non-small cell lung cancer cells: Erratum. | Xiu, Z., et al. 2023. J Cancer. 14: 1605-1606. PMID: 37325060
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- Effects of cytochalasin H on human lymphocyte cultures. | Mulherkar, L., et al. 1978. Indian J Exp Biol. 16: 430-4. PMID: 680852
- Inhibitory effect of cytochalasin H on cell reaggregation of the fresh water sponge, Ephydatia meyeni Carter. | Ghaskadbi, S. and Mulherkar, L. 1982. Exp Cell Biol. 50: 155-61. PMID: 7095250
- Structure of a new [11]cytochalasin, cytochalasin H or kodo-cytochalasin-1. | Beno, MA., et al. 1977. J Am Chem Soc. 99: 4123-30. PMID: 864107
- Toxicity and plant growth regulator effects of cytochalasin H isolated from Phomopsis sp. | Wells, JM., et al. 1976. Can J Microbiol. 22: 1137-43. PMID: 963626
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cytochalasin H, 1 mg | sc-202119 | 1 mg | $190.00 |