Cytochalasin E, Aspergillus clavatus (CAS 36011-19-5)

Cytochalasin E, a derivative of Aspergillus clavatus, is part of the Cytochalasin class of fungal toxins, known for their complex structure, including a highly substituted hydrogenated isoindole ring fused to a macrocyclic ring. This compound is particularly utilized in research to explore actin polymerization and its impact on actin dynamics. It functions by binding to the barbed end of actin filaments, which blocks both the addition and removal of actin subunits, thereby disrupting the polymerization of actin. This disruption significantly affects various cellular activities reliant on actin, such as movement, division, and internalization processes. Cytochalasin E, Aspergillus clavatus serves as a critical tool in delving into the intricate behaviors of actin filaments within cellular signaling, transportation within cells, and the reorganization of the cytoskeleton, offering valuable insights into both normal and abnormal cellular processes. Notably, Cytochalasin E, Aspergillus clavatus is distinct from other Cytochalasins like A and B, as it does not interfere with sugar transport across cell membranes, underscoring its specific utility in studying actin-related phenomena. The Cytochalasin family, including variants like Cytochalasin C, D, H, and J, presents a range of compounds for detailed scientific exploration, each with its unique attributes and effects, facilitating a broad spectrum of research applications.