Molecular structure of Cytochalasin C, CAS Number: 22144-76-9
Cytochalasin C (CAS 22144-76-9)
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Application:
Cytochalasin C is a cell-permeable fungal toxin used in actin polymerization studies and cytological research
CAS Number:
22144-76-9
Purity:
≥95%
Molecular Weight:
507.6
Molecular Formula:
C30H37NO6
Supplemental Information:
This is as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Cytochalasin C is used in actin polymerization studies. Cytochalasins are potent mycotoxins which bind to the barbed end of actin filaments resulting in inhibition of both the association and dissociation of subunits. Used as a tool for cytological research. These fungal toxins are related by their chemical structure characterized by a highly substituted hydrogenated isoindole ring to which is fused a macrocyclic ring. Cytochalasin C has shown to be 10 times less toxic in mice than cytochalasin D (sc-201442), but with essentially the same biological effectiveness against cells in culture. Other Cytochalasins available: Cytochalasin A (sc-204705) cytochalasin B (sc-3519) Cytochalasin E, Aspergillus clavatus (sc-202561) Cytochalasin H (sc-202119) Cytochalasin J (sc-202120)
Cytochalasin C (CAS 22144-76-9) References
- Tolerated doses in zebrafish of cytochalasins and jasplakinolide for comparison with tolerated doses in mice in the evaluation of pre-clinical activity of microfilament-directed agents in tumor model systems in vivo. | Trendowski, M., et al. 2014. In Vivo. 28: 1021-31. PMID: 25398795
- Antiplasmodial and Cytotoxic Cytochalasins from an Endophytic Fungus, Nemania sp. UM10M, Isolated from a Diseased Torreya taxifolia Leaf. | Kumarihamy, M., et al. 2019. Molecules. 24: PMID: 30795572
- Cytotoxic cytochalasans from fungus Xylaria longipes. | Wang, WX., et al. 2019. Fitoterapia. 137: 104278. PMID: 31351910
- Effects of cytochalasin and phalloidin on actin. | Cooper, JA. 1987. J Cell Biol. 105: 1473-8. PMID: 3312229
- Tandem MS-Based Metabolite Profiling of 19,20-Epoxycytochalasin C Reveals the Importance of a Hydroxy Group at the C7 Position for Biological Activity. | Kushwaha, M., et al. 2021. ACS Omega. 6: 3717-3726. PMID: 33585752
- Resolution of the Hypoxylon fuscum Complex (Hypoxylaceae, Xylariales) and Discovery and Biological Characterization of Two of Its Prominent Secondary Metabolites. | Lambert, C., et al. 2021. J Fungi (Basel). 7: PMID: 33670169
- Actin assembly activity of cytochalasins and cytochalasin analogs assayed using fluorescence photobleaching recovery. | Walling, EA., et al. 1988. Arch Biochem Biophys. 264: 321-32. PMID: 3395126
- The cytochalasins as research tools in cytology. | Carter, SB. 1972. Endeavour. 31: 77-82. PMID: 4113813
- Effects of cytochalasins on mammalian cells. | Carter, SB. 1967. Nature. 213: 261-4. PMID: 6067685
- Structure-activity correlations of cytochalasins. Novel halogenated and related cytochalasin C and D derivatives. | Patwardhan, BH., et al. 1982. J Med Chem. 25: 663-6. PMID: 7097721
- Correlation between effects of 24 different cytochalasins on cellular structures and cellular events and those on actin in vitro. | Yahara, I., et al. 1982. J Cell Biol. 92: 69-78. PMID: 7199054
- Alteration in cell morphology triggers transforming growth factor-beta 1, collagenase, and tissue inhibitor of metalloproteinases-I expression in normal and hypertrophic scar fibroblasts. | Varedi, M., et al. 1995. J Invest Dermatol. 104: 118-23. PMID: 7528243
- Cytoskeleton regulates expression of genes for transforming growth factor-beta 1 and extracellular matrix proteins in dermal fibroblasts. | Varedi, M., et al. 1997. J Cell Physiol. 172: 192-9. PMID: 9258340
Inhibitor of:
DNAH7, and MYH13.Activator of:
γ2-COP, ACTBL1, ACTL10, CCDC65, COPB, PRR16, and TM7SF3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cytochalasin C, 1 mg | sc-202118 | 1 mg | $120.00 | |||
Cytochalasin C, 5 mg | sc-202118A | 5 mg | $502.00 |