Curcumin is a yellow-orange dye obtained from tumeric, the powdered root of Curcuma longa; it is employed in the preparation of curcuma paper, the detection of boron, and possesses a vast number of biological targets. A study investigating the effects of curcumin on reported inflammatory mediators in inflammatory bowel disease on colonic myofibroblasts obtained ex vivo reported that a dose-dependent suppression of matrix metalloproteinase-3 (MMP-3) occured. Curcumin has been shown to inhibit NF-κB, possibly through inhibition of JNK (IC50=10 μM). Curcumin blocks amyloid peptide induced expression of: TNF-α, IL-1β, MCP-1, IL-8, and CCR5, regulates NOS2, inhibits IgE and Ag-induced degranulation of mast cells, inhibits 5-LO (5-lipoxygenase) (IC50=8 μM), Cox-2 (cyclooxygenase-2) (IC50=52 μM), the COP9 signalosome kinase (IC50=10μM), and p300/CREB Binding Protein (p300/CBP). This wide range of activities makes curcumin an extremely useful tool for developing novel analogues and uses. Curcumin is an inhibitor of GST, IKK and NQO1.
1. Flynn, D.L., et al. 1986. Prostaglandins Leukot Med. 22: 357-360. PMID: 3460103
2. Flynn, D.L., et al. 1986. Prostaglandins Leukot Med. 24: 195-198. PMID: 3467378
3. Chan, M.M. 1995. Biochem. Pharmacol. 49: 1551-1556. PMID: 7786295
4. Kuo, M.L., et al. 1996. Biochim. Biophys. Acta. 1317: 95-100. PMID: 8950193
5. Singh, A.K., et al. 1996. Cancer Lett. 107: 109-115. PMID: 8913274
6. Jiang, M.C., et al. 1996. Nutr Cancer. 26: 111-120. PMID: 8844727
7. Sokoloski, J.A., et al. 1997. Oncol. Res. 9: 31-39. PMID: 9112258
8. Kumar, A., et al. 1998. Biochem. Pharmacol. 55: 775-783. PMID: 9586949
9. Chen, Y.R. and Tan, T.H. 1998. Oncogene. 17: 173-178. PMID: 9674701
See how others have used Curcumin. Click on the entry to view the PubMed entry .
PMID: # 28958556
Grzesik, M. et al. 2018. Antioxidant properties of catechins: Comparison with other antioxidants. Food Chem. 241: 480-492.
PMID: # 28603085
Fernández-Del-Río, L. et al. 2017. Kaempferol increases levels of coenzyme Q in kidney cells and serves as a biosynthetic ring precursor. Free Radic. Biol. Med.. 110: 176-187.
PMID: # 24418562
Narayanan, A. et al. 2014. Reactive oxygen species activate NFκB (p65) and p53 and induce apoptosis in RVFV infected liver cells. Virology. 449: 270-86.
PMID: # 22847000
Narayanan, A. et al. 2012. Curcumin inhibits Rift Valley fever virus replication in human cells. The Journal of biological chemistry. 287: 33198-214.
PMID: # 15738001
Choudhuri, T. et al. 2005. Curcumin selectively induces apoptosis in deregulated cyclin D1-expressed cells at G2 phase of cell cycle in a p53-dependent manner. J. Biol. Chem.. 280: 20059-20068.
PMID: # 12578124
Gaddipati, JP. et al. 2003. Differential regulation of cytokines and transcription factors in liver by curcumin following hemorrhage/resuscitation. Shock. 19: 150-156.
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