Curcumin An inhibitor of 5-LO, Cox-2, and NOS2

Curcumin  (CAS 458-37-7)

Curcumin is rated 4.0 out of 5 by 1.
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| See 4 Citations
Synonym: Diferuloylmethane; Turmeric yellow; Natural yellow 3
Application: An inhibitor of 5-LO, Cox-2, and NOS2
CAS Number: 458-37-7
Purity: ≥95%
Molecular Weight: 368.38
Molecular Formula: C21H20O6
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
Curcumin sc-200509 1 g $19.00
Curcumin sc-200509A 5 g $38.00
Curcumin sc-200509B 25 g $60.00

Curcumin is a yellow-orange dye obtained from tumeric, the powdered root of Curcuma longa; it is employed in the preparation of curcuma paper, the detection of boron, and possesses a vast number of biological targets. A study investigating the effects of curcumin on reported inflammatory mediators in inflammatory bowel disease on colonic myofibroblasts obtained ex vivo reported that a dose-dependent suppression of matrix metalloproteinase-3 (MMP-3) occured. Curcumin has been shown to inhibit NF-κB, possibly through inhibition of JNK (IC50=10 μM). Curcumin blocks amyloid peptide induced expression of: TNF-α, IL-1β, MCP-1, IL-8, and CCR5, regulates NOS2, inhibits IgE and Ag-induced degranulation of mast cells, inhibits 5-LO (5-lipoxygenase) (IC50=8 μM), Cox-2 (cyclooxygenase-2) (IC50=52 μM), the COP9 signalosome kinase (IC50=10μM), and p300/CREB Binding Protein (p300/CBP). This wide range of activities makes curcumin an extremely useful tool for developing novel analogues and uses. Curcumin is an inhibitor of GST, IKK and NQO1.


References

1. Flynn, D.L., et al. 1986. Prostaglandins Leukot Med. 22: 357-360. PMID: 3460103
2. Flynn, D.L., et al. 1986. Prostaglandins Leukot Med. 24: 195-198. PMID: 3467378
3. Chan, M.M. 1995. Biochem. Pharmacol. 49: 1551-1556. PMID: 7786295
4. Kuo, M.L., et al. 1996. Biochim. Biophys. Acta. 1317: 95-100. PMID: 8950193
5. Singh, A.K., et al. 1996. Cancer Lett. 107: 109-115. PMID: 8913274
6. Jiang, M.C., et al. 1996. Nutr Cancer. 26: 111-120. PMID: 8844727
7. Sokoloski, J.A., et al. 1997. Oncol. Res. 9: 31-39. PMID: 9112258
8. Kumar, A., et al. 1998. Biochem. Pharmacol. 55: 775-783. PMID: 9586949
9. Chen, Y.R. and Tan, T.H. 1998. Oncogene. 17: 173-178. PMID: 9674701

Appearance :
Powder
Physical State :
Solid
Derived From :
Turmeric rhizome
Solubility :
Soluble in ethanol (10 mg/ml), DMSO (25 mg/ml), acetic acid, 0.1M NaOH, 10mM Na2CO3, acetone, water (< 0.1 mg/ml), and chloroform.
Storage :
Store at room temperature
Melting Point :
170-175° C
Boiling Point :
~591.4° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.42
IC50 :
5-lipoxygenase: IC50 = 8 µM; cyclooxygenase: IC50 = 52 µM; nitric oxide synthase in activated macrophages: IC50 = 6 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
MI5230000
PubChem CID :
969516
Merck Index :
14: 2673
MDL Number :
MFCD00008365
EC Number :
207-280-5
Beilstein Registry :
2306965
SMILES :
COC1=C(C=CC(=C1)/C=C/C(=O)CC(=O)/C=C/C2=CC(=C(C=C2)O)OC)O

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Certificate of Analysis

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Curcumin Product Citations

See how others have used Curcumin. Click on the entry to view the PubMed entry .

Citations 1 to 4 of 4 total

PMID: # 22847000
Narayanan, A. et al. 2012. Curcumin inhibits Rift Valley fever virus replication in human cells. The Journal of biological chemistry. 287: 33198-214.

PMID: # 15738001
Choudhuri, T. et al. 2005. Curcumin selectively induces apoptosis in deregulated cyclin D1-expressed cells at G2 phase of cell cycle in a p53-dependent manner. J. Biol. Chem.. 280: 20059-20068.

PMID: # 12578124
Gaddipati, JP. et al. 2003. Differential regulation of cytokines and transcription factors in liver by curcumin following hemorrhage/resuscitation. Shock. 19: 150-156.

Citations 1 to 4 of 4 total

What is the recommended storage temperature? How should this be stored when dissolved?

Asked by: chemicalsmg
Thank you for your question. The compound, sc-200509, should be stored at room temperature. Once dissolved, the solution should remain stable for approximately 3 months if stored at -20&ordm;C. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing scbt@scbt.com, or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2017-01-26
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Rated 4 out of 5 by from I will rate this product a 4 and rate 5 I will rate this product a 4 and rate 5 for your logistics, customer service and support.
Date published: 2015-04-20
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