Date published: 2026-1-6

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Coenzyme A (CAS 85-61-0 anhydrous)

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Alternate Names:
CoA; CoASH; Aluzime; Coalip
Application:
Coenzyme A is an essential cofactor in enzymatic acetyl transfer reactions
CAS Number:
85-61-0 anhydrous
Purity:
≥85%
Molecular Weight:
767.53
Molecular Formula:
C21H36N7O16P3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Coenzyme A (CoA) is an essential metabolic cofactor synthesized from cysteine, pantothenate, and ATP. Coenzyme A plays important roles in many metabolic pathways, including the tricarboxylic acid cycle, and the synthesis and oxidation of fatty acids. One of the main functions of Coenzyme A is the carrying and transfer of acyl groups. Acylated deriviates, for example acetyl-CoA, are critical intermediates in many metabolic reactions. Coenzyme A levels can be altered during starvation, and in conditions such as cancer, diabetes, and alcoholism. Coenzyme A can bind acetate (Acetyl-CoA) or other carboxylic acids in an energy-rich binding. It is cofactor of many enzyme-catalysed acetylations, e. g. in the citrate cycle (Krebs cycle). For improving the sensitivity of the luciferase assay, Coenzyme A is added to the assay buffer at a concentration of 270 muM.


Coenzyme A (CAS 85-61-0 anhydrous) References

  1. Coenzyme A contained in mothers' milk is associated with the potential to induce atopic dermatitis.  |  Higashi, T., et al. 2011. Int Immunol. 23: 741-9. PMID: 22039014
  2. Coenzyme A and coenzyme A-glutathione mixed disulfide measurements by HPLC.  |  Rogers, LK. and Smith, CV. 2003. Curr Protoc Toxicol. Chapter 6: Unit6.9. PMID: 23045095
  3. Coenzyme A and its derivatives: renaissance of a textbook classic.  |  Theodoulou, FL., et al. 2014. Biochem Soc Trans. 42: 1025-32. PMID: 25109997
  4. Signalling functions of coenzyme A and its derivatives in mammalian cells.  |  Davaapil, H., et al. 2014. Biochem Soc Trans. 42: 1056-62. PMID: 25110002
  5. LC-MS/MS-based analysis of coenzyme A and short-chain acyl-coenzyme A thioesters.  |  Neubauer, S., et al. 2015. Anal Bioanal Chem. 407: 6681-8. PMID: 26168961
  6. Coenzyme A metabolism.  |  Robishaw, JD. and Neely, JR. 1985. Am J Physiol. 248: E1-9. PMID: 2981478
  7. Coenzyme A: a protective thiol in bacterial antioxidant defence.  |  Gout, I. 2019. Biochem Soc Trans. 47: 469-476. PMID: 30783014
  8. Regulation of coenzyme A levels by degradation: the 'Ins and Outs'.  |  Naquet, P., et al. 2020. Prog Lipid Res. 78: 101028. PMID: 32234503
  9. Coenzyme A and affinity chromatography.  |  Chibata, I., et al. 1974. Methods Enzymol. 34: 267-71. PMID: 4155783
  10. Transport of coenzyme A in plant mitochondria.  |  Neuburger, M., et al. 1984. Arch Biochem Biophys. 229: 253-8. PMID: 6703695
  11. A rapid method for the synthesis of methylmalonyl-coenzyme A and other CoA-esters.  |  Padmakumar, R., et al. 1993. Anal Biochem. 214: 318-20. PMID: 8250241
  12. A nonradioactive assay for ribosome-inactivating proteins.  |  Langer, M., et al. 1996. Anal Biochem. 243: 150-3. PMID: 8954537
  13. Large-scale synthesis of coenzyme A esters.  |  Padmakumar, R., et al. 1997. Methods Enzymol. 279: 220-4. PMID: 9211274
  14. Effects of L-carnitine on erythrocyte acyl-CoA, free CoA, and glycerophospholipid acyltransferase in uremia.  |  de los Reyes, B., et al. 1998. Am J Clin Nutr. 67: 386-90. PMID: 9497180

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Coenzyme A, 10 mg

sc-211123
10 mg
$83.00

Coenzyme A, 25 mg

sc-211123A
25 mg
$135.00

Coenzyme A, 100 mg

sc-211123B
100 mg
$418.00

Coenzyme A, 250 mg

sc-211123C
250 mg
$801.00