Molecular structure of Chlorpheniramine Maleate, CAS Number: 113-92-8
Chlorpheniramine Maleate (CAS 113-92-8)
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Alternate Names:
Puermin; Chlortrimeton
Application:
Chlorpheniramine Maleate is an antagonist of the histamine H1-receptor
CAS Number:
113-92-8
Purity:
≥99%
Molecular Weight:
390.87
Molecular Formula:
C16H19ClN2•C4H4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Chlorpheniramine Maleate is a small molecule H1-receptor antagonist. Increased ornithine decarboxylase activity induced in an ischemia-reperfusion state was attenuated by Chlorpheniramine Maleate, indicating that this increase is mediated through engagement of the H1-receptor by histamine. Histamine-mediated repair of intestinal mucosa following ischemia-reperfusion was also demonstrated to operate through the H1-receptor with Chlorpheniramine Maleate. Induction of ornithine decarboxylase was blocked by Chlorpheniramine Maleate in Ehrlich carcinoma and MCF-7 cells. The positive inotropic effect of H1-receptor stimulation by histamine on protein tyrosine phosphorylation in guinea pig left atrium was antagonized by Chlorpheniramine Maleate.
Chlorpheniramine Maleate (CAS 113-92-8) References
- Involvement of tyrosine phosphorylation in the positive inotropic effect produced by H(1)-receptors with histamine in guinea-pig left atrium. | Akaishi, Y., et al. 2000. Br J Pharmacol. 130: 907-15. PMID: 10864899
- Histaminergic effect on apoptosis of rat small intestinal mucosa after ischemia-reperfusion. | Yoshida, T., et al. 2000. Dig Dis Sci. 45: 1138-44. PMID: 10877229
- In vivo visualization and analysis of ciliary motion in allergic rhinitis models induced by ovalbumin. | Liu, C., et al. 2022. Exp Biol Med (Maywood). 247: 1287-1297. PMID: 35507096
- Non-Destructive Analysis of Chlorpheniramine Maleate Tablets and Granules by Chemometrics-Assisted Attenuated Total Reflectance Infrared Spectroscopy. | Phechkrajang, C., et al. 2022. Molecules. 27: PMID: 35744885
- Uptake and Transport of Different Concentrations of PPCPs by Vegetables. | Zeng, Y., et al. 2022. Int J Environ Res Public Health. 19: PMID: 36497913
- Successful Desensitization to the Radiocontrast Material Iohexol (Omnipaque™). | Saad, A., et al. 2022. Cureus. 14: e32356. PMID: 36628042
- Chlorpheniramine Maleate Throat Spray for the Treatment of COVID-19-Induced Acute Viral Pharyngitis: Case Series. | Tesch, ML., et al. 2023. Cureus. 15: e34310. PMID: 36860214
- Combination of Cellulose Derivatives and Chitosan-Based Polymers to Investigate the Effect of Permeation Enhancers Added to In Situ Nasal Gels for the Controlled Release of Loratadine and Chlorpheniramine. | Viswanadhan Vasantha, P., et al. 2023. Polymers (Basel). 15: PMID: 36904447
- Effectiveness of budesonide formoterol fixed-dose combination MDI in reducing cough symptoms in COVID-19 patients: A real-world evidence study. | Samajdar, SS., et al. 2023. Lung India. 40: 107-111. PMID: 37006092
- A chiral metal-organic framework {(HQA)(ZnCl2)(2.5H2O)}n for the enantioseparation of chiral amino acids and drugs. | Zheng, X., et al. 2023. J Pharm Anal. 13: 421-429. PMID: 37181296
- The Rise of SARS-CoV-2 (COVID-19) Omicron Subvariant Pathogenicity. | DeGrasse, DC. and Black, SD. 2023. Cureus. 15: e40148. PMID: 37313287
- A Rare Incidence of Sweating Sickness-Like Symptoms in a Crossbred Holstein Friesian Cow in Chattogram, Bangladesh. | Faruq, O., et al. 2023. Case Rep Vet Med. 2023: 6470133. PMID: 37324955
- Role of histamine receptors in intestinal repair after ischemia-reperfusion in rats. | Tsunada, S., et al. 1994. Gastroenterology. 107: 1297-304. PMID: 7523223
- Chlorpheniramine inhibits the synthesis of ornithine decarboxylase and the proliferation of human breast cancer cell lines. | Medina, MA., et al. 1995. Breast Cancer Res Treat. 35: 187-94. PMID: 7647340
Inhibitor of:
HDC, and Histamine H1 Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Chlorpheniramine Maleate, 5 g | sc-204684 | 5 g | $42.00 | |||
Chlorpheniramine Maleate, 25 g | sc-204684A | 25 g | $97.00 |