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Carbenoxolone disodium (CAS 7421-40-1)

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Alternate Names:
3β-Hydroxy-11-oxoolean-12-en-30-oic acid 3-hemisuccinate
Application:
Carbenoxolone disodium is an inhibitor of 11 β-hydroxysteroid dehydrogenase (11β-HSD)
CAS Number:
7421-40-1
Purity:
≥98%
Molecular Weight:
614.72
Molecular Formula:
C34H48O72Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Carbenoxolone disodium is a compound of interest in various research fields, particularly in studies concerning cellular communication and physiology. It is known to inhibit the activity of 11β-hydroxysteroid dehydrogenase and gap junction communication, which are significant in the regulation of steroid hormone action and intercellular signaling, respectively. These properties make carbenoxolone disodium a useful tool in the investigation of hormonal regulation of metabolism and the role of gap junctions in tissue homeostasis and disease. In neurobiology, the compound is used to explore the influence of gap junctions on neuronal activity and the synchronization of neuronal networks. Additionally, researchers study the effects of carbenoxolone disodium on inflammation and immune responses, given its impact on cellular communication pathways. Its role in modulating water and salt balance is also a subject of interest, particularly in understanding the mechanisms of ion transport in epithelial tissues.


Carbenoxolone disodium (CAS 7421-40-1) References

  1. Effect of carbenoxolone sodium on steroid-induced sodium transport in the toad bladder: further studies.  |  Brem, AS., et al. 1992. J Steroid Biochem Mol Biol. 42: 911-4. PMID: 1525050
  2. Carbenoxolone inhibits junctional transfer and upregulates Connexin43 expression by a protein kinase A-dependent pathway.  |  Sagar, GD. and Larson, DM. 2006. J Cell Biochem. 98: 1543-51. PMID: 16552723
  3. Pectin-based bioadhesive delivery of carbenoxolone sodium for aphthous ulcers in oral cavity.  |  Wattanakorn, N., et al. 2010. AAPS PharmSciTech. 11: 743-51. PMID: 20443091
  4. Carbenoxolone prevents the development of fatty liver in C57BL/6-Lep ob/ob mice via the inhibition of sterol regulatory element binding protein-1c activity and apoptosis.  |  Rhee, SD., et al. 2012. Eur J Pharmacol. 691: 9-18. PMID: 22742899
  5. 15-PGDH inhibitors: the antiulcer effects of carbenoxolone, pioglitazone and verapamil in indomethacin induced peptic ulcer rats.  |  Moustafa, YM., et al. 2013. Eur Rev Med Pharmacol Sci. 17: 2000-9. PMID: 23884819
  6. Intrathecal carbenoxolone inhibits neuropathic pain and spinal wide-dynamic range neuronal activity in rats after an L5 spinal nerve injury.  |  Xu, Q., et al. 2014. Neurosci Lett. 563: 45-50. PMID: 24486838
  7. Carbenoxolone induces permeability transition pore opening in rat mitochondria via the translocator protein TSPO and connexin43.  |  Azarashvili, T., et al. 2014. Arch Biochem Biophys. 558: 87-94. PMID: 24995971
  8. Decreased fast ripples in the hippocampus of rats with spontaneous recurrent seizures treated with carbenoxolone and quinine.  |  Ventura-Mejía, C. and Medina-Ceja, L. 2014. Biomed Res Int. 2014: 282490. PMID: 25276773
  9. Regulation of epithelial sodium channel expression by oestradiol and progestogen in alveolar epithelial cells.  |  Luo, L., et al. 2015. Respir Physiol Neurobiol. 216: 52-62. PMID: 26051998
  10. Unilateral microinjection of carbenoxolone into the pontis caudalis nucleus inhibits the pentylenetetrazole-induced epileptiform activity in rats.  |  Franco-Pérez, J., et al. 2015. Neurosci Lett. 602: 38-43. PMID: 26141611
  11. Redox-Active Mn Porphyrin-based Potent SOD Mimic, MnTnBuOE-2-PyP(5+), Enhances Carbenoxolone-Mediated TRAIL-Induced Apoptosis in Glioblastoma Multiforme.  |  Yulyana, Y., et al. 2016. Stem Cell Rev Rep. 12: 140-55. PMID: 26454429
  12. Effect of carbenoxolone on ionic fluxes across normal gastric mucosa and that associated with gastric ulcer.  |  Ivey, KJ. and Gray, C. 1973. Aust N Z J Med. 3: 451-6. PMID: 4591118
  13. Biochemical effects of short-term treatment with carbenoxolone disodium.  |  Hausmann, W. and Tárnoky, AL. 1966. Br J Pharmacol Chemother. 26: 412-20. PMID: 5912688
  14. Differential inhibition of 11 beta-hydroxysteroid dehydrogenase by carbenoxolone in rat brain regions and peripheral tissues.  |  Jellinck, PH., et al. 1993. J Steroid Biochem Mol Biol. 46: 209-13. PMID: 8664169

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Carbenoxolone disodium, 1 g

sc-203868
1 g
$45.00

Carbenoxolone disodium, 5 g

sc-203868A
5 g
$197.00

Carbenoxolone disodium, 10 g

sc-203868B
10 g
$351.00

Carbenoxolone disodium, 25 g

sc-203868C
25 g
$759.00

Carbenoxolone disodium (CAS 7421-40-1) If I order it now, when will it be shipped?

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Date published: 2019-02-10
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Rated 5 out of 5 by from high qualityThe quality is very good, let me successfully completed the experiment, recommend everyone to use
Date published: 2016-11-06
Rated 5 out of 5 by from Lots of products to help you with your researchLots of products to help you with your research from antibodies to expression vectors and labeling reagents. Not anything you couldn't find anywhere else
Date published: 2015-10-26
Rated 5 out of 5 by from Zou H; et alZou H; et al. (PubMed ID: 26165643): determined that Carbenoxolone disodium, a gap junction blocker, protected BRL 3A rat liver cells from (Cd)-induced hepatotoxicity. -SCBT Publication Review
Date published: 2015-04-25
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Carbenoxolone disodium is rated 5.0 out of 5 by 3.
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