Molecular structure of Caffeic acid phenethyl ester, CAS Number: 104594-70-9
Caffeic acid phenethyl ester (CAS 104594-70-9)
See product citations (19)
Alternate Names:
Caffeic acid phenethyl ester is also known as CAPE.
Application:
Caffeic acid phenethyl ester is an inhibitor of ornithine decarboxylase, protein tyrosine kinase and lipoxygenase activities.
CAS Number:
104594-70-9
Purity:
≥98%
Molecular Weight:
284.31
Molecular Formula:
C17H16O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Caffeic acid phenethyl ester is a constituent of the propolis of honeybee hives and may act to contain inhibitory effects on induced papilloma promotion in mice. Caffeic acid phenethyl ester acts as an anti-proliferative agent in over-productive cell growth. Caffeic acid phenethyl ester can cause DNA fragmentation and apoptosis which can have toxic results towards cloned rat embryo fibroblast (CREF) cells. CREF cells depleted of cellular glutathione (GSH) seemed to be more sensitive to Caffeic acid phenethyl ester-induced cell death. Caffeic acid phenethyl ester has been reported to have anti-carcinogenic, anti-inflammatory, and immunomodulatory properties. Caffeic acid phenethyl ester inhibits HIV-1 integrase. The anti-inflammatory characteristics have been thought to be due to suppression of the lipoxygenase pathway of arachidonic acid metabolism by Caffeic acid phenethyl ester. Caffeic acid phenethyl ester to be a specific and potent inhibitor of activation of nuclear transcription factor NF kappa B, which is a protein complex that controls the transcription of DNA.
Caffeic acid phenethyl ester (CAS 104594-70-9) References
- FA-97, a New Synthetic Caffeic Acid Phenethyl Ester Derivative, Protects against Oxidative Stress-Mediated Neuronal Cell Apoptosis and Scopolamine-Induced Cognitive Impairment by Activating Nrf2/HO-1 Signaling. | Wan, T., et al. 2019. Oxid Med Cell Longev. 2019: 8239642. PMID: 31885818
- Interaction between caffeic acid/caffeic acid phenethyl ester and micellar casein. | Qin, J., et al. 2021. Food Chem. 349: 129154. PMID: 33556721
- The Pluripotent Activities of Caffeic Acid Phenethyl Ester. | Olgierd, B., et al. 2021. Molecules. 26: PMID: 33801469
- Combination treatment of docetaxel with caffeic acid phenethyl ester suppresses the survival and the proliferation of docetaxel-resistant prostate cancer cells via induction of apoptosis and metabolism interference. | Fu, YK., et al. 2022. J Biomed Sci. 29: 16. PMID: 35197069
- Caffeic acid phenethyl ester suppresses intestinal FXR signaling and ameliorates nonalcoholic fatty liver disease by inhibiting bacterial bile salt hydrolase activity. | Zhong, XC., et al. 2023. Acta Pharmacol Sin. 44: 145-156. PMID: 35655096
- Caffeic acid phenethyl ester alleviated hypouricemia in hyperuricemic mice through inhibiting XOD and up-regulating OAT3. | Yong, T., et al. 2022. Phytomedicine. 103: 154256. PMID: 35714456
- Caffeic acid phenethyl ester inhibits pseudo-allergic reactions via inhibition of MRGPRX2/MrgprB2-dependent mast cell degranulation. | Adhikari, N. and Shim, WS. 2022. Arch Pharm Res. 45: 644-657. PMID: 36183260
- Caffeic acid phenethyl ester ameliorates imidacloprid-induced acute toxicity in the rat cerebral cortex. | Eser, N., et al. 2022. Environ Toxicol Pharmacol. 96: 103980. PMID: 36191819
- Apoptosis and altered redox state induced by caffeic acid phenethyl ester (CAPE) in transformed rat fibroblast cells. | Chiao, C., et al. 1995. Cancer Res. 55: 3576-83. PMID: 7543016
- Caffeic acid phenethyl ester as a lipoxygenase inhibitor with antioxidant properties. | Sud'ina, GF., et al. 1993. FEBS Lett. 329: 21-4. PMID: 7689063
- Apoptosis mediates the selective toxicity of caffeic acid phenethyl ester (CAPE) toward oncogene-transformed rat embryo fibroblast cells. | Su, ZZ., et al. 1995. Anticancer Res. 15: 1841-8. PMID: 8572568
- Inhibitory effects of caffeic acid phenethyl ester (CAPE) on 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion in mouse skin and the synthesis of DNA, RNA and protein in HeLa cells. | Huang, MT., et al. 1996. Carcinogenesis. 17: 761-5. PMID: 8625488
- Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B. | Natarajan, K., et al. 1996. Proc Natl Acad Sci U S A. 93: 9090-5. PMID: 8799159
Inhibitor of:
Abin-3, AIM2, AP1, APOBEC3G, AQP0, Bikunin, BST-2, C2orf57, CARD 6, Casein Kinase II, caspase-7, CD16-2, CD32-B_Fc γ RIIb, CD66CE, chondroitin-4-sulfate, claudin-2, DC-LAMP, DNA-PKCS, DNA2, EG624439, EG624584, GAGE7B, Gastric Lipase, GSTT2, H2-M1, HAPLN1, HAPLN2, HAS3, Histone cluster 1 H3H, Histone cluster 1 H4F, HIV vpr, HIV-1 Integrase, hnRNP E2, HRF, HS3ST6, HVCN1, HYAL2, ICAM-4, IL-20, IL-23, IL-TIF, IRF-1, KCNH1, KIAA1199_9930013L23Rik, LCE1E, Lce1m, LCE3B-E, Lipocalin-12, LOC646324, LOC728685, Mucin, NALP9A, NALP9C, NF kappa B, NF-1B, NFκB p50, NFκB p52, NFATc1, NFATc4, NFRκB, ODC, p8, PSG11, Rad17, Retnlb, Ros, SerpinA9, Sp5, SPARC, SPRR4, SSRP1, ST2, T6BP, THP, Thrombospondin 3, TRADD, Tyrosine Kinase, WISP-2, YY1, and ZNF683.Activator of:
κB-Ras1, ALG14, ATXN7L2, bradykinin B1 R, CD48, CD89, CMBL, COMMD9, CST9L, Cyclophilin D, CYLD, Dectin-2, ECSIT, Factor B, FLJ43505, FRBZ1, GALC, GAS41, GILZ, Gsta1, GSTT2B, Histone cluster 1 H2BC, Histone cluster 1 H2BO, Histone cluster 1 H3J, Histone cluster 1 H4L, Histone cluster 2 H3C, Histone cluster 2 H4B, Histone H10, HLTF, IκB-β, IκB-δ, IFN-α7, IL-27, JWA, LCA5L, LCE1B, Lipocalin-8, LOC100040130, LOC100041215, LOC100041231, LOC145837, LRRN1, Ly-49H, MALT1, MAPKAP-1, MD-1, NFKBIL1, NKRF, NPAL3, NPN, OTTMUSG00000011792, PDGFR-B, PIAS 1, POLR2J3, RUNX3, SGK, SPINK6, Sprr2a2, Swi1, TAF II p43, TGIF2LX2, and ZC3HAV1L.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Caffeic acid phenethyl ester, 20 mg | sc-200800 | 20 mg | $70.00 | |||
Caffeic acid phenethyl ester, 100 mg | sc-200800A | 100 mg | $290.00 | |||
Caffeic acid phenethyl ester, 1 g | sc-200800B | 1 g | $600.00 |