Date published: 2025-10-14

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Butyric acid (CAS 107-92-6)

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Alternate Names:
Butanoic acid
Application:
Butyric acid is a histone deacetylase inhibitor
CAS Number:
107-92-6
Purity:
≥99%
Molecular Weight:
88.11
Molecular Formula:
C4H8O2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Butyric acid is a fatty acid isolated from many dairy products that exhibits anticancer activity. Butyric acid inhibits histone deacetylases (HDACs) and induces apoptosis and G1 phase cell cycle arrest in glioma cells. Additionally, it stimulates epithelial cell proliferation at low doses and inhibits proliferation at high doses. In cultured mammalian cells it affects growth rate, morphology, and gene expression. Within the cell, Butyric acid is primarily located in the cytoplasm, mitochondria and adiposome. Butyric acid exists in all eukaryotes, ranging from yeast to humans. In humans, it is involved in fatty acid biosynthesis pathway and the butyrate metabolism pathway. Outside of the human body, Butyric acid can be found in a number of food items such as garden rhubarb, endive, cucumber, and swede. This makes Butyric acid a potential biomarker for the consumption of these food products. In a study, exposure of the rat glioma C6 cell line to Butyric acid increased levels of L-triiodothyronine in the nuclear and extranuclear compartments. The increase in nuclear binding was not merely a reflection of the higher cellular hormone content, and Scatchard analysis of L-triiodothyronine binding to isolated nuclei revealed that butyric acid increased receptor number without changing affinity. Butyric acid increased receptor levels by decreasing receptor degradation. It had little effect in increasing the level of multiacetylated forms of H3 and H4 histone when studied in acid-urea gels, but it markedly inhibited the turnover of (3)H-acetate from the histone fraction.


Butyric acid (CAS 107-92-6) References

  1. Current progress on butyric acid production by fermentation.  |  Zhang, C., et al. 2009. Curr Microbiol. 59: 656-63. PMID: 19727942
  2. Butyric acid: what is the future for this old substance?  |  Sossai, P. 2012. Swiss Med Wkly. 142: w13596. PMID: 22674349
  3. Re-discovering periodontal butyric acid: New insights on an old metabolite.  |  Cueno, ME. and Ochiai, K. 2016. Microb Pathog. 94: 48-53. PMID: 26466516
  4. [Short chain fatty acids (butyric acid) and intestinal diseases].  |  Manrique Vergara, D. and González Sánchez, ME. 2017. Nutr Hosp. 34: 58-61. PMID: 29156934
  5. Recent advances and strategies in process and strain engineering for the production of butyric acid by microbial fermentation.  |  Luo, H., et al. 2018. Bioresour Technol. 253: 343-354. PMID: 29329775
  6. RIFM fragrance ingredient safety assessment, butyric acid, CAS Registry Number 107-92-6.  |  Api, AM., et al. 2019. Food Chem Toxicol. 127 Suppl 1: S81-S89. PMID: 30711719
  7. Lipid-regulating properties of butyric acid and 4-phenylbutyric acid: Molecular mechanisms and therapeutic applications.  |  He, B. and Moreau, R. 2019. Pharmacol Res. 144: 116-131. PMID: 30954630
  8. Biofiltration of butyric acid: Monitoring odor abatement and microbial communities.  |  Reyes, J., et al. 2020. Environ Res. 190: 110057. PMID: 32805248
  9. Butyric Acid Generation by Clostridium tyrobutyricum from Low-Moisture Anhydrous Ammonia (LMAA) Pretreated Sweet Sorghum Bagasse.  |  Stoklosa, RJ., et al. 2021. Appl Biochem Biotechnol. 193: 761-776. PMID: 33188509
  10. Physiological activity of E. coli engineered to produce butyric acid.  |  Park, YT., et al. 2022. Microb Biotechnol. 15: 832-843. PMID: 33729711
  11. Could the use of butyric acid have a positive effect on microbiota and treatment of type 2 diabetes?  |  Stachowska, E., et al. 2021. Eur Rev Med Pharmacol Sci. 25: 4570-4578. PMID: 34286509
  12. Mechanistic basis and preliminary practice of butyric acid and butyrate sodium to mitigate gut inflammatory diseases: a comprehensive review.  |  Zhang, M., et al. 2021. Nutr Res. 95: 1-18. PMID: 34757305
  13. Fecal level of butyric acid, a microbiome-derived metabolite, is increased in patients with severe carotid atherosclerosis.  |  Stø, K., et al. 2022. Sci Rep. 12: 22378. PMID: 36572703
  14. Butyric acid from the diet: actions at the level of gene expression.  |  Smith, JG., et al. 1998. Crit Rev Food Sci Nutr. 38: 259-97. PMID: 9626487
  15. Role of butyric acid and its derivatives in the treatment of colorectal cancer and hemoglobinopathies.  |  Pouillart, PR. 1998. Life Sci. 63: 1739-60. PMID: 9820119

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Butyric acid, 1 kg

sc-214640
1 kg
$63.00

Butyric acid, 10 kg

sc-214640A
10 kg
$174.00