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Butyric acid is a fatty acid isolated from many dairy products that exhibits anticancer activity. Butyric acid inhibits histone deacetylases (HDACs) and induces apoptosis and G1 phase cell cycle arrest in glioma cells. Additionally, it stimulates epithelial cell proliferation at low doses and inhibits proliferation at high doses. In cultured mammalian cells it affects growth rate, morphology, and gene expression. Within the cell, Butyric acid is primarily located in the cytoplasm, mitochondria and adiposome. Butyric acid exists in all eukaryotes, ranging from yeast to humans. In humans, it is involved in fatty acid biosynthesis pathway and the butyrate metabolism pathway. Outside of the human body, Butyric acid can be found in a number of food items such as garden rhubarb, endive, cucumber, and swede. This makes Butyric acid a potential biomarker for the consumption of these food products. In a study, exposure of the rat glioma C6 cell line to Butyric acid increased levels of L-triiodothyronine in the nuclear and extranuclear compartments. The increase in nuclear binding was not merely a reflection of the higher cellular hormone content, and Scatchard analysis of L-triiodothyronine binding to isolated nuclei revealed that butyric acid increased receptor number without changing affinity. Butyric acid increased receptor levels by decreasing receptor degradation. It had little effect in increasing the level of multiacetylated forms of H3 and H4 histone when studied in acid-urea gels, but it markedly inhibited the turnover of (3)H-acetate from the histone fraction.
Ordering Information
Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Butyric acid, 1 kg | sc-214640 | 1 kg | $63.00 | |||
Butyric acid, 10 kg | sc-214640A | 10 kg | $174.00 |