Molecular structure of Bergaptol, CAS Number: 486-60-2
Bergaptol (CAS 486-60-2)
Alternate Names:
4-Hydroxybergapten
CAS Number:
486-60-2
Molecular Weight:
202.16
Molecular Formula:
C11H6O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Bergaptol is believed to exert its effects through multiple mechanisms. It is thought to function as an antioxidant by effectively scavenging reactive oxygen species, while also displaying anti-inflammatory properties by inhibiting the production of pro-inflammatory cytokines. Additionally, there are indications that bergaptol may engage with various enzymes and receptors, further contributing to its potential actions.
Bergaptol (CAS 486-60-2) References
- Furanocoumarin biosynthesis in Ammi majus L. Cloning of bergaptol O-methyltransferase. | Hehmann, M., et al. 2004. Eur J Biochem. 271: 932-40. PMID: 15009205
- Radical scavenging and cytochrome P450 3A4 inhibitory activity of bergaptol and geranylcoumarin from grapefruit. | Girennavar, B., et al. 2007. Bioorg Med Chem. 15: 3684-91. PMID: 17400460
- Constitutive expression of bergaptol O-methyltransferase in Glehnia littoralis cell cultures. | Ishikawa, A., et al. 2009. Plant Cell Rep. 28: 257-65. PMID: 18974989
- Major furocoumarins in grapefruit juice I: levels and urinary metabolite(s). | Messer, A., et al. 2011. Food Chem Toxicol. 49: 3224-31. PMID: 21945416
- Effect of maturity, processing, and storage on the furanocoumarin composition of grapefruit and grapefruit juice. | Cancalon, PF., et al. 2011. J Food Sci. 76: C543-8. PMID: 22417333
- Characterization of coumarin-specific prenyltransferase activities in Citrus limon peel. | Munakata, R., et al. 2012. Biosci Biotechnol Biochem. 76: 1389-93. PMID: 22785469
- Cloning, Functional Characterization, and Catalytic Mechanism of a Bergaptol O-Methyltransferase from Peucedanum praeruptorum Dunn. | Zhao, Y., et al. 2016. Front Plant Sci. 7: 722. PMID: 27252733
- [Effects of methyl jasmonate on accumulation of furanocoumarins in Changium smyrnioides and its suspension cells]. | Cai, J., et al. 2017. Zhongguo Zhong Yao Za Zhi. 42: 76-82. PMID: 28945028
- Structure-based tailoring of the first coumarins-specific bergaptol O-methyltransferase to synthesize bergapten for depigmentation disorder treatment. | Zhao, Y., et al. 2020. J Adv Res. 21: 57-64. PMID: 31666994
- Bergaptol from blossoms of Citrus aurantium L. var. amara Engl inhibits LPS-induced inflammatory responses and ox-LDL-induced lipid deposition. | Shen, CY., et al. 2020. Food Funct. 11: 4915-4926. PMID: 32432251
- System pharmacology analysis to decipher the effect and mechanism of active ingredients combination from herb couple on rheumatoid arthritis in rats. | Wu, SS., et al. 2022. J Ethnopharmacol. 288: 114969. PMID: 34999146
- Bergaptol Alleviates LPS-Induced Neuroinflammation, Neurological Damage and Cognitive Impairment via Regulating the JAK2/STAT3/p65 Pathway. | Wu, J., et al. 2022. J Inflamm Res. 15: 6199-6211. PMID: 36386582
- Photooxygenation of some potentially skin-photosensitizing hydroxyfurocoumarins. Part 2: Xanthotoxol and bergaptol. | Abou Elzahab, M. 1993. Pharmazie. 48: 144-5. PMID: 8475160
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Bergaptol, 25 mg | sc-503534 | 25 mg | $445.00 |