Date published: 2025-9-30

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Benzocaine (CAS 94-09-7)

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Alternate Names:
Ethyl 4-aminobenzoate
Application:
Benzocaine is a surface anesthetic
CAS Number:
94-09-7
Purity:
≥99%
Molecular Weight:
165.19
Molecular Formula:
C9H11NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Benzocaine is a local anesthetic that functions by inhibiting the voltage-gated sodium channels in the cell membrane of neurons. This inhibition prevents the generation and conduction of nerve impulses, leading to a reversible loss of sensation in the area of application. Benzocaine achieves this by binding to the sodium channels and stabilizing the inactive state, thereby preventing the channels from opening in response to depolarization. This mechanism of action effectively blocks the transmission of signals along the nerve fibers, resulting in a numbing effect on the sensory nerves. By interfering with the normal function of the sodium channels, benzocaine disrupts the propagation of action potentials, ultimately leading to the temporary loss of sensation in the targeted area.


Benzocaine (CAS 94-09-7) References

  1. Benzocaine-induced methemoglobinemia: experience from a high-volume transesophageal echocardiography laboratory.  |  Novaro, GM., et al. 2003. J Am Soc Echocardiogr. 16: 170-5. PMID: 12574744
  2. Benzocaine-induced methemoglobinemia in an acute-exposure rat model.  |  Von Tungeln, LS., et al. 2011. Food Chem Toxicol. 49: 2530-5. PMID: 21726594
  3. Stability of benzocaine formulated in commercial oral disintegrating tablet platforms.  |  Köllmer, M., et al. 2013. AAPS PharmSciTech. 14: 1333-40. PMID: 23990120
  4. Benzocaine polymorphism: pressure-temperature phase diagram involving forms II and III.  |  Gana, I., et al. 2013. Int J Pharm. 456: 480-8. PMID: 23994015
  5. More methemoglobin is produced by benzocaine treatment than lidocaine treatment in human in vitro systems.  |  Hartman, NR., et al. 2014. Regul Toxicol Pharmacol. 70: 182-8. PMID: 25010377
  6. Protomers of benzocaine: solvent and permittivity dependence.  |  Warnke, S., et al. 2015. J Am Chem Soc. 137: 4236-42. PMID: 25760934
  7. Benzocaine loaded solid lipid nanoparticles: Formulation design, in vitro and in vivo evaluation of local anesthetic effect.  |  Basha, M., et al. 2015. Curr Drug Deliv. 12: 680-92. PMID: 26138680
  8. Methemoglobinemia Secondary to Topical Benzocaine Application to Gastrostomy Site.  |  Lipton, M., et al. 2016. Pediatr Emerg Care. 32: 312-4. PMID: 27139292
  9. Characterization of the methemoglobin forming metabolites of benzocaine and lidocaine.  |  Hartman, N., et al. 2017. Xenobiotica. 47: 431-438. PMID: 27321253
  10. The Analysis of the Physicochemical Properties of Benzocaine Polymorphs.  |  Paczkowska, M., et al. 2018. Molecules. 23: PMID: 30013003
  11. Benzocaine-induced stress in the euryhaline teleost, Centropomus parallelus and its implications for anesthesia protocols.  |  Wosnick, N., et al. 2018. Comp Biochem Physiol A Mol Integr Physiol. 226: 32-37. PMID: 30056161
  12. Evaluation of the aggregation process in a mixture of propofol and benzocaine.  |  León, I., et al. 2019. Phys Chem Chem Phys. 21: 3537-3544. PMID: 30137107
  13. A new high-pressure benzocaine polymorph - towards understanding the molecular aggregation in crystals of an important active pharmaceutical ingredient (API).  |  Patyk-Kaźmierczak, E. and Kaźmierczak, M. 2020. Acta Crystallogr B Struct Sci Cryst Eng Mater. 76: 56-64. PMID: 32831241
  14. Determination of Benzocaine in Pharmaceutical Formulations by Indirect SERRS Assay Combined with Azo Coupling.  |  Zhao, CY., et al. 2022. Molecules. 27: PMID: 35889365
  15. Supramolecular assembly of benzocaine bearing cyclodextrin cavity via host-guest complexes on polyacrylonitrile as an electrospun nanofiber.  |  Rajaram, R., et al. 2023. J Pharm Biomed Anal. 225: 115223. PMID: 36623427

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Benzocaine, 100 g

sc-239305
100 g
$29.00