Bakuchiol A PTP1B and DNA polymerase inhibitor

Bakuchiol (CAS 10309-37-2)

Bakuchiol | CAS 10309-37-2 is rated 5.0 out of 5 by 1.
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| See product citations (1)
Synonym: 4-(3-Ethenyl-3,7-dimethyl-1,6-octadienyl)phenol
Application: A PTP1B and DNA polymerase inhibitor
CAS Number: 10309-37-2
Purity: ≥97%
Molecular Weight: 256.4
Molecular Formula: C18H24O
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
Bakuchiol sc-202075 1 mg $40.00

Bakuchiol is an antioxidant inhibitor of protein tyrosine phosphatase 1B (PTP1B). It also acts as an inhibitor of mitochondrial lipid peroxidation and inducible nitric oxide synthase (iNOS; NOS II) expression. Bakuchiol is also a DNA polymerase inhibitor which shows antimicrobial and cytotoxic activity.


References

1. Pae, H.O. et al. 2001. Int. Immunopharmacol. 1(9-10): 1849-1855. PMID: 11562076
2. Backhouse, C.N. et al. 2001. J Ethnopharmacol. 78(1): 27-31. PMID: 11585684
3. Haraguchi, H. et al. 2002. Phytother Res. 16(6): 539-544. PMID: 12237811
4. Adhikari, S. et al. 2003. Chem. Res. Toxicol. 16(9): 1062-1069. PMID: 12971793
5. Bapat, K. et al. 2005. Appl Radiat Isot. 62(3): 389-393. PMID: 15607914
6. Kim, Y.C. et al. 2005. Planta Med. 71(1): 87-89. PMID: 15678382
7. Park, E.J. et al. 2005. Planta Med. 71(6): 508-513. PMID: 15971120
8. Park, E.J. et al. 2007. Eur. J. Pharmacol. 559(2-3): 115-123. PMID: 17292878

Appearance :
Oil
Physical State :
Liquid
Derived From :
Psoralea corylifolia
Solubility :
Soluble in DMSO, and 100% ethanol.
Storage :
Store at -20° C
Melting Point :
106.00° C (Predicted)
Boiling Point :
391.38° C (Predicted)
Density :
0.96 g/mL (Predicted)
Refractive Index :
n20D 1.56 (Predicted)
IC50 :
HeLa: IC50 = 11 µM (human); AGS: IC50 = 15.3 µM (human); T47D: IC50 = 28.9 µM (human)
pK Values :
pKa: 10.1 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
5468522
MDL Number :
MFCD01707441
SMILES :
CC(=CCC[C@@](C)(C=C)/C=C/C1=CC=C(C=C1)O)C

Download SDS (MSDS)

Certificate of Analysis

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BakuchiolProduct Citations

See how others have used Bakuchiol. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 25860621  Choi, JM. et al. 2015. Chem. Res. Toxicol. 28: 872-85.

Citations 1 to 1 of 1 total

Hello, I am a natural skin care formulator and I am interested in adding Bakuchiol to a prod. What percentage of Bakuchios recommended to be effective in an oil based product? Any info on how to use this ingredient in natural skin care is appreciated.

Asked by: alysha
Products are provided for research or laboratory use only (RUO) and are not to be administered to humans or used for medical diagnostics.
Answered by: Technical Support Europe
Date published: 2017-12-27
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Rated 5 out of 5 by from Park et al Park et al. (PubMed ID 17292878) found that bakuchiol reduced activated hepatic stellate cells of rats recovering from liver injury by inducing apoptosis via activation of caspase 3. -SCBT Publication Review
Date published: 2015-02-23
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