Molecular structure of Aminoguanidine hemisulfate, CAS Number: 996-19-0
Aminoguanidine hemisulfate (CAS 996-19-0)
Alternate Names:
Guanylhydrazine hemisulfate salt
Application:
Aminoguanidine hemisulfate is a NOS (nitric oxide synthase) inhibitor
CAS Number:
996-19-0
Purity:
≥98%
Molecular Weight:
123.1
Molecular Formula:
CH6N4•0.5H2SO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Aminoguanidine hemisulfate is an inhibitor of NOS (nitric oxide synthase) and NO (nitric oxide). Due to Aminoguanidine hemisulfate′s NO inhibition the compound was able to inhibit the immunosuppressing effects of an attenuated strain of Salmonella typhimurium. Another secondary effect observed by Aminoguanidine hemisulfate′s inhibition of NO is the prevention of diabetic vascular dysfunction in rats. Aminoguanidine hemisulfate is an inhibitor of NOS1 and NOS2.
Aminoguanidine hemisulfate (CAS 996-19-0) References
- Peripheral nitric oxide in carrageenan-induced inflammation. | Omote, K., et al. 2001. Brain Res. 912: 171-5. PMID: 11532433
- Aminoguanidine, a novel inhibitor of nitric oxide formation, prevents diabetic vascular dysfunction. | Corbett, JA., et al. 1992. Diabetes. 41: 552-6. PMID: 1376704
- Differential involvement of nitric oxide signaling in dopamine and PACAP stimulation of growth hormone release in goldfish. | Mitchell, G., et al. 2008. Gen Comp Endocrinol. 155: 318-27. PMID: 17574554
- Nitric oxide inhibits metamorphosis in larvae of Crepidula fornicata, the slippershell snail. | Pechenik, JA., et al. 2007. Biol Bull. 213: 160-71. PMID: 17928523
- Hepatic nitrosative stress in experimental diabetes. | Di Naso, FC., et al. 2012. J Diabetes Complications. 26: 378-81. PMID: 22699114
- The regulatory role of the NO/cGMP signal transduction cascade during larval attachment and metamorphosis of the barnacle Balanus (=Amphibalanus) amphitrite. | Zhang, Y., et al. 2012. J Exp Biol. 215: 3813-22. PMID: 22855617
- Regulation of boar sperm functionality by the nitric oxide synthase/nitric oxide system. | Staicu, FD., et al. 2019. J Assist Reprod Genet. 36: 1721-1736. PMID: 31325069
- Bivalves are NO different: nitric oxide as negative regulator of metamorphosis in the Pacific oyster, Crassostrea gigas. | Vogeler, S., et al. 2020. BMC Dev Biol. 20: 23. PMID: 33228520
- Areca nut extract (ANE) inhibits the progression of hepatocellular carcinoma cells via activation of ROS production and activation of autophagy. | Wei, PL., et al. 2021. Int J Med Sci. 18: 3452-3462. PMID: 34522171
- Effects of L-arginine on Nitric Oxide Synthesis and Larval Metamorphosis of Mytilus coruscus. | Zhu, YT., et al. 2023. Genes (Basel). 14: PMID: 36833378
- Aminoguanidine inhibits both constitutive and inducible nitric oxide synthase isoforms in rat intestinal microvasculature in vivo. | Laszlo, F., et al. 1995. Eur J Pharmacol. 272: 169-75. PMID: 7536162
- Selective inhibition of the inducible nitric oxide synthase by aminoguanidine. | Misko, TP., et al. 1993. Eur J Pharmacol. 233: 119-25. PMID: 7682510
- Effects of nitric oxide on ovulation and ovarian steroidogenesis and prostaglandin production in the rabbit. | Yamauchi, J., et al. 1997. Endocrinology. 138: 3630-7. PMID: 9275046
- In vivo blockage of nitric oxide with aminoguanidine inhibits immunosuppression induced by an attenuated strain of Salmonella typhimurium, potentiates Salmonella infection, and inhibits macrophage and polymorphonuclear leukocyte influx into the spleen. | MacFarlane, AS., et al. 1999. Infect Immun. 67: 891-8. PMID: 9916105
Inhibitor of:
Enzyme, NOS1, and NOS2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Aminoguanidine hemisulfate, 100 mg | sc-202930 | 100 mg | $20.00 | |||
Aminoguanidine hemisulfate, 500 mg | sc-202930A | 500 mg | $31.00 |