Amentoflavone (CAS 1617-53-4)

Amentoflavone is a biflavonoid compound, consisting of two flavone units linked together. This unique structure contributes to its broad spectrum of biological activities and makes it an intriguing subject for various scientific research areas, particularly in biochemistry and plant physiology. The primary mechanism of action of amentoflavone involves its ability to act as a potent antioxidant. Amentoflavone can scavenge free radicals and reduce oxidative stress in cells, which is crucial for studying the oxidative processes and their impact on cellular health and aging. This antioxidant capacity is attributed to the phenolic hydroxyl groups present in the flavone structure, which can donate electrons to neutralize reactive oxygen species. In research focused on cellular signaling and enzymatic activity, amentoflavone has been identified as an inhibitor of several key enzymes. It inhibits phosphodiesterases, which are involved in the breakdown of cyclic nucleotides within cells. This inhibition can lead to increased levels of cyclic AMP and cyclic GMP, which play significant roles in signal transduction and the regulation of metabolic processes. Amentoflavone also exhibits activity as a modulator of various receptors and ion channels. It has been shown to act as a non-competitive antagonist at the GABA-A receptor, influencing neurotransmission and neuronal activity.