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α-Methyl-γ-butyrolactone (CAS 1679-47-6)

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Alternate Names:
4,5-Dihydro-3-methyl-2(3H)-furanone
CAS Number:
1679-47-6
Molecular Weight:
100.12
Molecular Formula:
C5H8O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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α-Methyl-γ-butyrolactone finds extensive application in the synthesis of diverse compounds, encompassing proteins and various chemicals. As a solvent, it facilitates a wide array of reactions, ranging from the synthesis of proteins to other chemical compounds. Additionally, it serves as a reagent in the synthesis of polymers.


α-Methyl-γ-butyrolactone (CAS 1679-47-6) References

  1. Costunolide inhibits production of tumor necrosis factor-alpha and interleukin-6 by inducing heme oxygenase-1 in RAW264.7 macrophages.  |  Pae, HO., et al. 2007. Inflamm Res. 56: 520-6. PMID: 18210237
  2. An efficient synthesis of (+/-)-grandisol featuring 1,5-enyne metathesis.  |  Graham, TJ., et al. 2010. J Org Chem. 75: 226-8. PMID: 19957923
  3. Unusual C=C bond isomerization of an α,β-unsaturated γ-butyrolactone catalysed by flavoproteins from the old yellow enzyme family.  |  Durchschein, K., et al. 2012. Chembiochem. 13: 2346-51. PMID: 23024004
  4. Total synthesis and absolute configuration of curvularides A-E.  |  Sudhakar, G., et al. 2012. J Org Chem. 77: 10010-20. PMID: 23121599
  5. Combined experimental and theoretical study of the reactivity of γ-Butyro- and related lactones, with the OH radical at room temperature.  |  Barnes, I., et al. 2014. J Phys Chem A. 118: 5013-9. PMID: 24945977
  6. Functional annotation and structural characterization of a novel lactonase hydrolyzing D-xylono-1,4-lactone-5-phosphate and L-arabino-1,4-lactone-5-phosphate.  |  Korczynska, M., et al. 2014. Biochemistry. 53: 4727-38. PMID: 24955762
  7. A living foundry for Synthetic Biological Materials: A synthetic biology roadmap to new advanced materials.  |  Le Feuvre, RA. and Scrutton, NS. 2018. Synth Syst Biotechnol. 3: 105-112. PMID: 29900423
  8. A Comprehensive Characterisation of Volatile and Fatty Acid Profiles of Legume Seeds.  |  Khrisanapant, P., et al. 2019. Foods. 8: PMID: 31817745
  9. Screening of Bacterial Quorum Sensing Inhibitors in a Vibrio fischeri LuxR-Based Synthetic Fluorescent E. coli Biosensor.  |  Qin, X., et al. 2020. Pharmaceuticals (Basel). 13: PMID: 32971993
  10. Sesquiterpene Lactones: Promising Natural Compounds to Fight Inflammation.  |  Matos, MS., et al. 2021. Pharmaceutics. 13: PMID: 34208907
  11. Effect of Inoculation with Lentilactobacillus buchneri and Lacticaseibacillus paracasei on the Maize Silage Volatilome: The Advantages of Advanced 2D-Chromatographic Fingerprinting Approaches.  |  Squara, S., et al. 2022. J Agric Food Chem. 70: 12232-12248. PMID: 36103255
  12. Grifolamine A, a novel bis-γ-butyrolactone from Grifola frondosa exerted inhibitory effect on α-glucosidase and their binding interaction: Affinity and molecular dynamics simulation.  |  Chen, S., et al. 2022. Curr Res Food Sci. 5: 2045-2052. PMID: 36345431
  13. Voltage-dependent calcium channels as targets for convulsant and anticonvulsant alkyl-substituted thiobutyrolactones.  |  Gross, RA., et al. 1997. J Pharmacol Exp Ther. 280: 686-94. PMID: 9023280

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

α-Methyl-γ-butyrolactone, 5 g

sc-253859
5 g
$87.00

α-Methyl-γ-butyrolactone, 25 g

sc-253859A
25 g
$291.00