Molecular structure of α-Amyrin, CAS Number: 638-95-9
α-Amyrin (CAS 638-95-9)
See product citations (2)
Alternate Names:
Urs-12-en-3β-ol; Viminalol
Application:
α-Amyrin is a potential protein kinase A inhibitor
CAS Number:
638-95-9
Molecular Weight:
426.72
Molecular Formula:
C30H50O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
α-amyrin is a triterpenoid found in the bark of various trees like oaks and birches. This compound has been the subject of many laboratory studies and plays a role in the exploration of new drug development. It is utilized in research to investigate cellular signaling, gene expression, and apoptosis, as well as the impacts of oxidative stress, inflammation, and cancer. While the exact mechanism through which α-amyrin operates is not completely deciphered, it is thought to inhibit 5-lipoxygenase, an enzyme linked to the production of leukotrienes, which are associated with various conditions. In addition, α-amyrin is also suggested to function as an antioxidant, neutralizing free radicals and thus shielding cells from oxidative action.
α-Amyrin (CAS 638-95-9) References
- Antinociceptive properties of mixture of alpha-amyrin and beta-amyrin triterpenes: evidence for participation of protein kinase C and protein kinase A pathways. | Otuki, MF., et al. 2005. J Pharmacol Exp Ther. 313: 310-8. PMID: 15626726
- Triterpenoid α-amyrin stimulates proliferation of human keratinocytes but does not protect them against UVB damage. | Biskup, E., et al. 2012. Acta Biochim Pol. 59: 255-60. PMID: 22577623
- Amyrin attenuates scopolamine-induced cognitive impairment in mice. | Park, SJ., et al. 2014. Biol Pharm Bull. 37: 1207-13. PMID: 24989012
- Modulatory potential of α-amyrin against hepatic oxidative stress through antioxidant status in Wistar albino rats. | Singh, D., et al. 2015. J Ethnopharmacol. 161: 186-93. PMID: 25542388
- α-Amyrin attenuates high fructose diet-induced metabolic syndrome in rats. | Prabhakar, P., et al. 2017. Appl Physiol Nutr Metab. 42: 23-32. PMID: 27911087
- Practical Synthesis of α-Amyrin, β-Amyrin, and Lupeol: The Potential Natural Inhibitors of Human Oxidosqualene Cyclase. | Chen, D., et al. 2017. Arch Pharm (Weinheim). 350: PMID: 29027714
- Productive Amyrin Synthases for Efficient α-Amyrin Synthesis in Engineered Saccharomyces cerevisiae. | Yu, Y., et al. 2018. ACS Synth Biol. 7: 2391-2402. PMID: 30216049
- Antioxidant activity of α and β-amyrin isolated from Myrcianthes pungens leaves. | Karen Cardoso, B., et al. 2020. Nat Prod Res. 34: 1777-1781. PMID: 30465617
- Bioactive triterpenoids from Sambucus javanica Blume. | Chen, F., et al. 2020. Nat Prod Res. 34: 2816-2821. PMID: 30968700
- Molecular Docking and Molecular Dynamics Studies on Selective Synthesis of α-Amyrin and β-Amyrin by Oxidosqualene Cyclases from Ilex Asprella. | Wu, Z., et al. 2019. Int J Mol Sci. 20: PMID: 31311103
- Engineering Saccharomyces cerevisiae for high yield production of α-amyrin via synergistic remodeling of α-amyrin synthase and expanding the storage pool. | Yu, Y., et al. 2020. Metab Eng. 62: 72-83. PMID: 32841679
- α-Amyrin induces GLUT4 translocation mediated by AMPK and PPARδ/γ in C2C12 myoblasts. | Giacoman-Martínez, A., et al. 2021. Can J Physiol Pharmacol. 99: 935-942. PMID: 33596122
- α-amyrin-loaded nanocapsules produce selective cytotoxic activity in leukemic cells. | Neto, SF., et al. 2021. Biomed Pharmacother. 139: 111656. PMID: 34243603
- Synthesis, Biological Evaluation, and Molecular Docking Study of 3-Amino and 3-Hydroxy-seco A Derivatives of α-Amyrin and 3-Epilupeol as Inhibitors of COX-2 Activity and NF-kB Activation. | Romero-Estrada, A., et al. 2022. J Nat Prod. 85: 787-803. PMID: 35175765
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
α-Amyrin, 1 mg | sc-257029A | 1 mg | $204.00 | |||
α-Amyrin, 10 mg | sc-257029 | 10 mg | $318.00 | |||
α-Amyrin, 25 mg | sc-257029B | 25 mg | $531.00 | |||
α-Amyrin, 50 mg | sc-257029C | 50 mg | $847.00 |