Molecular structure of Aloesin, CAS Number: 30861-27-9
Aloesin (CAS 30861-27-9)
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Alternate Names:
Aloeresin B; 8-β-D-Glucopyranosyl-7-hydroxy-5-methyl-2-(2-oxopropyl)-4H-1-benzopyran-4-one
Application:
Aloesin is a tyrosinase inhibitor and free radical scavenger
CAS Number:
30861-27-9
Purity:
≥98%
Molecular Weight:
394.37
Molecular Formula:
C19H22O9
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Aloesin is a compound that functions as a tyrosinase inhibitor, effectively reducing the production of melanin in cells. It acts by inhibiting the activity of the enzyme tyrosinase, which is involved in the production of melanin. This inhibition leads to a decrease in the synthesis of melanin, which may be useful for studying melanin production and skin pigmentation in experimental applications. Aloesin′s mechanism of action involves binding to the active site of tyrosinase, preventing the enzyme from catalyzing the conversion of tyrosine to melanin. This interaction at the molecular level disrupts the normal process of melanin production.
Aloesin (CAS 30861-27-9) References
- Aloesin and arbutin inhibit tyrosinase activity in a synergistic manner via a different action mechanism. | Jin, YH., et al. 1999. Arch Pharm Res. 22: 232-6. PMID: 10403123
- Mushroom tyrosinase inhibition activity of some chromones. | Piao, LZ., et al. 2002. Chem Pharm Bull (Tokyo). 50: 309-11. PMID: 11911191
- Modulation of melanogenesis by aloesin: a competitive inhibitor of tyrosinase. | Jones, K., et al. 2002. Pigment Cell Res. 15: 335-40. PMID: 12213089
- Aloesin inhibits hyperpigmentation induced by UV radiation. | Choi, S., et al. 2002. Clin Exp Dermatol. 27: 513-5. PMID: 12372097
- Antioxidant, free radical scavenging and anti-inflammatory effects of aloesin derivatives in Aloe vera. | Yagi, A., et al. 2002. Planta Med. 68: 957-60. PMID: 12451482
- Determination of aloesin and aloeresin A for the detection of aloe in beverages. | Dell'Agli, M., et al. 2007. J Agric Food Chem. 55: 3363-7. PMID: 17419646
- Aloesin as a medical food ingredient for systemic oxidative stress of diabetes. | Yimam, M., et al. 2015. World J Diabetes. 6: 1097-107. PMID: 26265996
- Aloesin from Aloe vera accelerates skin wound healing by modulating MAPK/Rho and Smad signaling pathways in vitro and in vivo. | Wahedi, HM., et al. 2017. Phytomedicine. 28: 19-26. PMID: 28478809
- Aloesin Suppresses Cell Growth and Metastasis in Ovarian Cancer SKOV3 Cells through the Inhibition of the MAPK Signaling Pathway. | Zhang, LQ., et al. 2017. Anal Cell Pathol (Amst). 2017: 8158254. PMID: 28702312
- Depigmentation and Anti-aging Treatment by Natural Molecules. | Zaid, AN. and Al Ramahi, R. 2019. Curr Pharm Des. 25: 2292-2312. PMID: 31269882
- Pharmacological Update Properties of Aloe Vera and its Major Active Constituents. | Sánchez, M., et al. 2020. Molecules. 25: PMID: 32183224
- Extraction of Aloesin from Aloe vera Rind Using Alternative Green Solvents: Process Optimization and Biological Activity Assessment. | Añibarro-Ortega, M., et al. 2021. Biology (Basel). 10: PMID: 34681050
- Aloesin up-regulates cyclin E/CDK2 kinase activity via inducing the protein levels of cyclin E, CDK2, and CDC25A in SK-HEP-1 cells. | Lee, KY., et al. 1997. Biochem Mol Biol Int. 41: 285-92. PMID: 9063568
Inhibitor of:
P protein, TRP2, and Tyrosinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Aloesin, 1 mg | sc-202450 | 1 mg | $262.00 |