Aloesin A tyrosinase inhibitor and free radical scavenger

Aloesin (CAS 30861-27-9)

Aloesin | CAS 30861-27-9 is rated 5.0 out of 5 by 1.
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Synonym: Aloeresin B; 8-β-D-Glucopyranosyl-7-hydroxy-5-methyl-2-(2-oxopropyl)-4H-1-benzopyran-4-one
Application: A tyrosinase inhibitor and free radical scavenger
CAS Number: 30861-27-9
Purity: ≥98%
Molecular Weight: 394.37
Molecular Formula: C19H22O9
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
Aloesin sc-202450 1 mg $124.00

Aloesin is a C-glycosylated chromone compound that has shown competitive inhibitory activity of tyrosinase, an enzyme responsible for catalyzing phenol oxidation in plants. Derivatives of aloesin have been observed to exhibit free radical scavenging and anti-inflammatory activity, and this compound has also been reported to modulate the formation of melanin (melanogenesis).


References

1. Piao, L.Z., et al. 2002. Chem. Pharm. Bull. 50: 309-311. PMID: 11911191
2. Choi, S., et al. 2002. Clin. Exp. Dermatol. 27: 513-515. PMID: 12372097
3. Jones, K., et al. 2002. Pigment Cell Res. 15: 335-340. PMID: 12213089
4. Yagi, A., et al. 2002. Planta Med. 68: 957-960. PMID: 12451482
5. Dell'Agli, M., et al. 2007. J. Agric. Food Chem. 55: 3363-3367. PMID: 17419646

Appearance :
Powder
Physical State :
Solid
Derived From :
Aloe sp.
Solubility :
Soluble in DMSO, and 100% ethanol.
Storage :
Store at -20° C
Melting Point :
272.85° C (Predicted)
Boiling Point :
628.04° C at 760 mmHg (Predicted)
Density :
1.50 g/cm3 (Predicted)
Refractive Index :
n20D 1.64 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
160190
MDL Number :
MFCD00869744
SMILES :
CC1=CC(=C(C2=C1C(=O)C=C(O2)CC(=O)C)[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O)O

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Yagi et al Yagi et al. (PubMed ID 12451482) found that aloesin exhibited anti-inflammatory effects due to its DPPH radical and superoxide scavenger activity. It also had inhibitory activities on COX 2 and thromboxane A2 synthase. -SCBT Publication Review -SCBT Publication Review
Date published: 2015-01-18
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