Aloesin is a C-glycosylated chromone compound that has shown competitive inhibitory activity of tyrosinase, an enzyme responsible for catalyzing phenol oxidation in plants. Derivatives of aloesin have been observed to exhibit free radical scavenging and anti-inflammatory activity, and this compound has also been reported to modulate the formation of melanin (melanogenesis).
1. Piao, L.Z., et al. 2002. Chem. Pharm. Bull. 50: 309-311. PMID: 11911191 2. Choi, S., et al. 2002. Clin. Exp. Dermatol. 27: 513-515. PMID: 12372097 3. Jones, K., et al. 2002. Pigment Cell Res. 15: 335-340. PMID: 12213089 4. Yagi, A., et al. 2002. Planta Med. 68: 957-960. PMID: 12451482 5. Dell'Agli, M., et al. 2007. J. Agric. Food Chem. 55: 3363-3367. PMID: 17419646
Soluble in DMSO, and 100% ethanol.
Store at -20° C
272.85° C (Predicted)
628.04° C at 760 mmHg (Predicted)
1.50 g/cm3 (Predicted)
n20D 1.64 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Yagi et alYagi et al. (PubMed ID 12451482) found that aloesin exhibited anti-inflammatory effects due to its DPPH radical and superoxide scavenger activity. It also had inhibitory activities on COX 2 and thromboxane A2 synthase. -SCBT Publication Review -SCBT Publication Review
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