Molecular structure of 9Z,11E,13E-Octadecatrienoic Acid, CAS Number: 506-23-0
9Z,11E,13E-Octadecatrienoic Acid (CAS 506-23-0)
Application:
9Z,11E,13E-Octadecatrienoic Acid is an inhibitor of DNA polymerases and topoisomerases
CAS Number:
506-23-0
Molecular Weight:
278.4
Molecular Formula:
C18H30O2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
9Z,11E,13E-Octadecatrienoic Acid (α-ESA) is a conjugated polyunsaturated fatty acid found in plant seed oil. This fatty acid makes up about 60% of the total fatty acid composition of bitter gourd seed oil and about 70% in tung oil. In rats, 9Z,11E,13E-Octadecatrienoic was metabolized and converted to conjugated linoleic acid (9Z,11E-CLA). It has shown potential as a tumor suppressor. In Caco-2 colon cancer cells, alpha-ESA triggered apoptosis through up-regulation of GADD45, p53, and PPARγ. In DLD-1 cells supplemented with 9Z,11E,13E-Octadecatrienoic, apoptosis was triggered via lipid peroxidation. It also inhibits DNA polymerases and topoisomerases with IC50s ranging from ~5-20 µM for different isoforms of the enzymes.
9Z,11E,13E-Octadecatrienoic Acid (CAS 506-23-0) References
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Inhibitor of:
DNA Polymerase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
9Z,11E,13E-Octadecatrienoic Acid, 5 mg | sc-358735 | 5 mg | $408.00 |