9-Deoxo-9a-aza-9a-homo Erythromycin A Desmethyl Azithromycin (CAS 76801-85-9)

9-Deoxo-9a-aza-9a-homo Erythromycin A Desmethyl Azithromycin, identified by the CAS number 76801-85-9, is a semi-synthetic derivative of erythromycin, a well-known macrolide antibiotic. This compound is structurally modified to enhance certain properties, such as stability and binding efficiency. It retains the macrolide core that is pivotal for its mechanism of action—binding to the 50S subunit of bacterial ribosomes. By attaching to this specific ribosomal subunit, the compound inhibits the translocation steps of protein synthesis. This action effectively blocks the addition of new amino acids to nascent peptide chains, thus halting the production of essential proteins required for bacterial growth and survival. In scientific research, 9-Deoxo-9a-aza-9a-homo Erythromycin A Desmethyl Azithromycin has been utilized as a tool to study the structural and functional dynamics of macrolide interaction with bacterial ribosomes. These studies are crucial for understanding how molecular alterations in macrolides affect their action at a cellular level, particularly in terms of ribosomal binding and the inhibition of protein synthesis. Furthermore, research involving this compound assists in elucidating mechanisms behind the efficacy and resistance patterns of macrolide antibiotics, contributing significantly to the field of antibacterial resistance and the development of novel antibacterial agents.