7-Methylxanthine (CAS 552-62-5)
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7-Methylxanthine is a metabolite of theophylline and caffeine. It is a methylated form of the xanthine class of compounds, which are naturally occurring alkaloids found in plants and animals. 7-Methylxanthine works by blocking the action of the enzyme cyclic adenosine monophosphate (cAMP) phosphodiesterase. This enzyme is responsible for the breakdown of cAMP, which is an important messenger molecule involved in many cellular processes. By blocking the action of this enzyme, 7-Methylxanthine increases the levels of cAMP, which can have a variety of effects on the cell. It also it can increase the activity of the enzyme adenosine triphosphatase, which is involved in the breakdown of adenosine triphosphate (ATP). In addition, 7-Methylxanthine can increase the expression of certain genes involved in the regulation of energy metabolism, as well as increase the activity of certain calcium channels.
7-Methylxanthine (CAS 552-62-5) References
- Biochemical and ultrastructural changes in rabbit sclera after treatment with 7-methylxanthine, theobromine, acetazolamide, or L-ornithine. | Trier, K., et al. 1999. Br J Ophthalmol. 83: 1370-5. PMID: 10574816
- 7-Methylxanthine methyltransferase of coffee plants. Gene isolation and enzymatic properties. | Ogawa, M., et al. 2001. J Biol Chem. 276: 8213-8. PMID: 11108716
- Effects of 7-methylxanthine on the sclera in form deprivation myopia in guinea pigs. | Cui, D., et al. 2011. Acta Ophthalmol. 89: 328-34. PMID: 19860777
- Systemic 7-methylxanthine in retarding axial eye growth and myopia progression: a 36-month pilot study. | Trier, K., et al. 2008. J Ocul Biol Dis Infor. 1: 85-93. PMID: 20072638
- Effects of 7-methylxanthine on form-deprivation myopia in pigmented rabbits. | Nie, HH., et al. 2012. Int J Ophthalmol. 5: 133-7. PMID: 22762036
- The Adenosine Receptor Antagonist, 7-Methylxanthine, Alters Emmetropizing Responses in Infant Macaques. | Hung, LF., et al. 2018. Invest Ophthalmol Vis Sci. 59: 472-486. PMID: 29368006
- Effect of 7-methylxanthine on human retinal pigment epithelium cells cultured in vitro. | Wan, W., et al. 2017. Mol Vis. 23: 1006-1014. PMID: 29386874
- Xanthine urolithiasis: Inhibitors of xanthine crystallization. | Grases, F., et al. 2018. PLoS One. 13: e0198881. PMID: 30157195
- 3-Methylxanthine production through biodegradation of theobromine by Aspergillus sydowii PT-2. | Zhou, B., et al. 2020. BMC Microbiol. 20: 269. PMID: 32854634
- Sub-chronic and chronic toxicity evaluation of 7-methylxanthine: a new molecule for the treatment of myopia. | Singh, H., et al. 2022. Drug Chem Toxicol. 45: 1383-1394. PMID: 33076712
- 7-Methylxanthine Influences the Behavior of ADORA2A-DRD2 Heterodimers in Human Retinal Pigment Epithelial Cells. | Fan, Y., et al. 2022. Ophthalmic Res. 65: 678-684. PMID: 35724635
- Oral administration of caffeine metabolite 7-methylxanthine is associated with slowed myopia progression in Danish children. | Trier, K., et al. 2022. Br J Ophthalmol.. PMID: 35995571
- Biocatalytic production of 7-methylxanthine by a caffeine-degrading Escherichia coli strain. | Mock, MB., et al. 2022. Biotechnol Bioeng. 119: 3326-3331. PMID: 36059194
- Genotoxic and mutagenic potential of 7-methylxanthine: an investigational drug molecule for the treatment of myopia. | Singh, H., et al. 2023. Drug Chem Toxicol. 1-10. PMID: 36594462
- Mixed culture biocatalytic production of the high-value biochemical 7-methylxanthine. | Mock, MB. and Summers, RM. 2023. J Biol Eng. 17: 2. PMID: 36627657
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
7-Methylxanthine, 250 mg | sc-233694 | 250 mg | $195.00 | |||
7-Methylxanthine, 2.5 g | sc-233694A | 2.5 g | $895.00 |