Molecular structure of 7-Acetoxy-4-methylcoumarin, CAS Number: 2747-05-9
7-Acetoxy-4-methylcoumarin (CAS 2747-05-9)
See product citations (1)
Alternate Names:
4-Methylumbelliferyl acetate
Application:
7-Acetoxy-4-methylcoumarin is a fluorogenic substrate for carboxylesterase
CAS Number:
2747-05-9
Purity:
99%
Molecular Weight:
218.2
Molecular Formula:
C12H10O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
7-Acetoxy-4-methylcoumarin is a fluorogenic substrate for carboxylesterase yielding a blue fluorescent solution upon cleavage. The compound has been used in aprotic media, a cell membrane environmental mimic, to study superoxide and related oxyl-radical reactions of model biological membranes dispersed in aqueous media. Due to the ability for AchE to cleave and activate 7-Acetoxy-4-methylcoumarin, the fluorogenic substrate has been used to study the AchE inhibitor Tacrine·HCl (sc-200172). The compound has also been isolated from Trigonella foenum graceum.
7-Acetoxy-4-methylcoumarin (CAS 2747-05-9) References
- Interaction of tetrahydroaminoacridine with acetylcholinesterase and butyrylcholinesterase. | Berman, HA. and Leonard, K. 1992. Mol Pharmacol. 41: 412-8. PMID: 1538717
- Comparative specificities of Calreticulin Transacetylase to O-acetyl, N-acetyl and S-acetyl derivative of 4-methylcoumarins and their inhibitory effect on AFB1-induced genotoxicity in vitro and in vivo. | Kumar, A., et al. 2013. Food Chem Toxicol. 52: 216-24. PMID: 23182742
- Downregulation of Rubisco Activity by Non-enzymatic Acetylation of RbcL. | Gao, X., et al. 2016. Mol Plant. 9: 1018-27. PMID: 27109602
- Mitigation of radiation-induced gastro-intestinal injury by the polyphenolic acetate 7, 8-diacetoxy-4-methylthiocoumarin in mice. | Venkateswaran, K., et al. 2019. Sci Rep. 9: 14134. PMID: 31575959
- Non-Enzymatic Protein Acetylation by 7-Acetoxy-4-Methylcoumarin: Implications in Protein Biochemistry. | Bhatt, AN., et al. 2020. Protein Pept Lett. 27: 736-743. PMID: 32133945
- Site-directed mutagenesis in the P-domain of calreticulin transacylase identifies Lys-207 as the active site residue. | Joshi, R., et al. 2021. 3 Biotech. 11: 113. PMID: 33585151
- Are Molecularly Imprinted Polymers (MIPs) Beneficial in Detection and Determination of Mycotoxins in Cereal Samples? | Hatamabadi, D., et al. 2020. Iran J Pharm Res. 19: 1-18. PMID: 33841516
- Characterization of volatile organic compounds with anti-atherosclerosis effects in Allium macrostemon Bge. and Allium chinense G. Don by head space solid phase microextraction coupled with gas chromatography tandem mass spectrometry. | Qin, Z., et al. 2023. Front Nutr. 10: 996675. PMID: 36819690
- Can superoxide organic chemistry be observed within the liposomal bilayer? | Frimer, AA., et al. 1996. Free Radic Biol Med. 20: 843-52. PMID: 8728033
Substrate of:
Enzyme.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
7-Acetoxy-4-methylcoumarin, 5 g | sc-206060 | 5 g | $96.00 | |||
7-Acetoxy-4-methylcoumarin, 25 g | sc-206060A | 25 g | $300.00 |