Molecular structure of 7,8-Dihydroxyflavone, CAS Number: 38183-03-8
7,8-Dihydroxyflavone (CAS 38183-03-8)
See product citations (2)
Alternate Names:
7,8-DHF; 7,8-Dihydroxy-2-phenyl-4H-1-benzopyran-4-one
Application:
7,8-Dihydroxyflavone is a TrkB agonist that inhibits glutamate-triggered apoptosis
CAS Number:
38183-03-8
Molecular Weight:
254.24
Molecular Formula:
C15H10O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
7,8-Dihydroxyflavone hydrate functions as a highly selective and effective activator of the TrkB receptor, which is integral to neurotrophic signaling pathways. 7,8-Dihydroxyflavone hydrate affinity for the TrkB receptor allows it to trigger a series of downstream signaling pathways for neuronal survival, differentiation, and the strengthening of synaptic connections. Through its targeted interaction with this receptor, 7,8-Dihydroxyflavone hydrate provides probing the mechanisms of neuronal resilience and the processes governing synaptic plasticity. It is particularly useful in studying the cellular and molecular underpinnings of learning and memory. Its role in promoting long-term potentiation highlights its relevance in dissecting the molecular intricacies of neural connectivity.
7,8-Dihydroxyflavone (CAS 38183-03-8) References
- A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone. | Jang, SW., et al. 2010. Proc Natl Acad Sci U S A. 107: 2687-92. PMID: 20133810
- A synthetic 7,8-dihydroxyflavone derivative promotes neurogenesis and exhibits potent antidepressant effect. | Liu, X., et al. 2010. J Med Chem. 53: 8274-86. PMID: 21073191
- Effect of 7,8-dihydroxyflavone, a small-molecule TrkB agonist, on emotional learning. | Andero, R., et al. 2011. Am J Psychiatry. 168: 163-72. PMID: 21123312
- 7,8-dihydroxyflavone, a TrkB receptor agonist, blocks long-term spatial memory impairment caused by immobilization stress in rats. | Andero, R., et al. 2012. Hippocampus. 22: 399-408. PMID: 21136519
- Antioxidant activity of 7,8-dihydroxyflavone provides neuroprotection against glutamate-induced toxicity. | Chen, J., et al. 2011. Neurosci Lett. 499: 181-5. PMID: 21651962
- 7,8-dihydroxyflavone exhibits therapeutic efficacy in a mouse model of Rett syndrome. | Johnson, RA., et al. 2012. J Appl Physiol (1985). 112: 704-10. PMID: 22194327
- O-methylated metabolite of 7,8-dihydroxyflavone activates TrkB receptor and displays antidepressant activity. | Liu, X., et al. 2013. Pharmacology. 91: 185-200. PMID: 23445871
- 7,8-dihydroxyflavone prevents synaptic loss and memory deficits in a mouse model of Alzheimer's disease. | Zhang, Z., et al. 2014. Neuropsychopharmacology. 39: 638-50. PMID: 24022672
- 7,8-Dihydroxyflavone improves memory consolidation processes in rats and mice. | Bollen, E., et al. 2013. Behav Brain Res. 257: 8-12. PMID: 24070857
- Antioxidant action of 7,8-dihydroxyflavone protects PC12 cells against 6-hydroxydopamine-induced cytotoxicity. | Han, X., et al. 2014. Neurochem Int. 64: 18-23. PMID: 24220540
- 7,8-dihydroxyflavone ameliorates scopolamine-induced Alzheimer-like pathologic dysfunction. | Chen, C., et al. 2014. Rejuvenation Res. 17: 249-54. PMID: 24325271
- 7,8-dihydroxyflavone, a small molecular TrkB agonist, is useful for treating various BDNF-implicated human disorders. | Liu, C., et al. 2016. Transl Neurodegener. 5: 2. PMID: 26740873
- Treatment with the flavonoid 7,8-Dihydroxyflavone: a promising strategy for a constellation of body and brain disorders. | Emili, M., et al. 2022. Crit Rev Food Sci Nutr. 62: 13-50. PMID: 32914634
- 7,8-Dihydroxyflavone and Neuropsychiatric Disorders: A Translational Perspective from the Mechanism to Drug Development. | Yang, S. and Zhu, G. 2022. Curr Neuropharmacol. 20: 1479-1497. PMID: 34525922
Inhibitor of:
Apoptosis, Cephalosporin, Lingo-4, PTPN21, and TH.Activator of:
ATMIN, ATP9A, Bex1, C230078M14Rik, CASKIN2, KNDC1, Lingo-2, LRFN2, LRRTM3, Neuritin, NMDAε2, Peripherin, SEZ6L2, SIAH-1, Tak1, Trk B, and Trk C.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
7,8-Dihydroxyflavone, 100 mg | sc-278634 | 100 mg | $51.00 |