Molecular structure of 4-Amino-1,8-naphthalimide, CAS Number: 1742-95-6
4-Amino-1,8-naphthalimide (CAS 1742-95-6)
See product citations (4)
Alternate Names:
6-amino-1H-benz[de]isoquinoline-1
Application:
4-Amino-1,8-naphthalimide is a PARP-1 inhibitor
CAS Number:
1742-95-6
Purity:
≥96%
Molecular Weight:
212.2
Molecular Formula:
C12H8N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
4-Amino-1,8-naphthalimide is a small molecule inhibitor of PARP-1 (poly (ADP-ribose) polymerase-1), an enzyme responsible for mediating covalent attachment of residues to proteins. Inhibition of this enzyme can sensitize cells to the cytotoxicity of chemical agents, and can also decrease cell death related to reperfusion and ischemia-related oxygen free radicals by attenuating the rapid depletion of cellular NAD and ATP resulting from excessive activation of PARP.
4-Amino-1,8-naphthalimide (CAS 1742-95-6) References
- Role of zinc in pulmonary endothelial cell response to oxidative stress. | Tang, ZL., et al. 2001. Am J Physiol Lung Cell Mol Physiol. 281: L243-9. PMID: 11404267
- Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase. | Banasik, M., et al. 1992. J Biol Chem. 267: 1569-75. PMID: 1530940
- Cerebral endothelial cell apoptosis after ischemia-reperfusion: role of PARP activation and AIF translocation. | Zhang, Y., et al. 2005. J Cereb Blood Flow Metab. 25: 868-77. PMID: 15729291
- Unexpected fluorescent behavior of a 4-amino-1,8-naphthalimide derived beta-cyclodextrin: conformation analysis and sensing properties. | Zhong, C., et al. 2009. Chem Commun (Camb). 4091-3. PMID: 19568643
- Demonstration of bidirectional photoinduced electron transfer (PET) sensing in 4-amino-1,8-naphthalimide based thiourea anion sensors. | Veale, EB., et al. 2009. Org Biomol Chem. 7: 3447-54. PMID: 19675899
- 4-Amino-1,8-naphthalimide-based Tröger's bases as high affinity DNA targeting fluorescent supramolecular scaffolds. | Veale, EB., et al. 2009. Org Lett. 11: 4040-3. PMID: 19681640
- Synthesis, photophysical, and DNA binding studies of fluorescent Tröger's base derived 4-amino-1,8-naphthalimide supramolecular clefts. | Veale, EB. and Gunnlaugsson, T. 2010. J Org Chem. 75: 5513-25. PMID: 20704427
- A naphthalimide fluorophore with efficient intramolecular PET and ICT processes: application in molecular logic. | Wang, H., et al. 2011. Org Biomol Chem. 9: 5436-44. PMID: 21660342
- Targetable, two-photon fluorescent probes for local nitric oxide capture in the plasma membranes of live cells and brain tissues. | Zhang, X., et al. 2018. Analyst. 143: 4180-4188. PMID: 30070265
- Poly-ADP Ribosyl Polymerase 1 (PARP1) Regulates Influenza A Virus Polymerase. | Westera, L., et al. 2019. Adv Virol. 2019: 8512363. PMID: 31015836
- A study of 99mTc/Re-tricarbonyl complexes of 4-amino-1,8-naphthalimides. | Turnbull, WL., et al. 2019. Dalton Trans. 48: 14077-14084. PMID: 31490511
- Learning from Artemisinin: Bioinspired Design of a Reaction-Based Fluorescent Probe for the Selective Sensing of Labile Heme in Complex Biosystems. | Xu, S., et al. 2020. J Am Chem Soc. 142: 2129-2133. PMID: 31955575
- Inhibition of the activity of poly(ADP ribose) synthetase reduces ischemia-reperfusion injury in the heart and skeletal muscle. | Thiemermann, C., et al. 1997. Proc Natl Acad Sci U S A. 94: 679-83. PMID: 9012844
Inhibitor of:
Apoptosis, and PARP-1.Activator of:
ZNF440.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4-Amino-1,8-naphthalimide, 20 mg | sc-200125 | 20 mg | $78.00 | |||
4-Amino-1,8-naphthalimide, 100 mg | sc-200125A | 100 mg | $310.00 |