Date published: 2025-12-1

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(3-Mercaptopropyl)trimethoxysilane (CAS 4420-74-0)

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Alternate Names:
3-(Trimethoxysilyl)-1-propanethiol; 3-(Trimethoxysilyl)propanethiol
Application:
(3-Mercaptopropyl)trimethoxysilane is a useful chemical for silicate glass surface modification by Thiol–Ene Polymerization
CAS Number:
4420-74-0
Purity:
95%
Molecular Weight:
196.34
Molecular Formula:
C6H16O3SSi
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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(3-Mercaptopropyl)trimethoxysilane is a clear, colorless to yellow liquid soluble in organic solvents like ethanol, acetone, and benzene. It has various applications in different areas such as material science and surface chemistry due to its ability to modify surface properties. This chemical is used to modify a diverse set of materials such as metals, ceramics, and polymers, enhancing their adhesion, wetting, and a range of other physicochemical attributes. (3-Mercaptopropyl)trimethoxysilane can be used as a capping agent or reducing agent in the synthesis of nanoparticles, such as gold and silver nanoparticles, to control their size, shape, and stability. It is also instrumental to functionalize the surfaces of biosensors, including electrochemical and optical ones, contributing to the optimization of their sensitivity, selectivity, and stability. (3-Mercaptopropyl)trimethoxysilane is a useful chemical for silicate glass surface modification Thiol–Ene Polymerization.


(3-Mercaptopropyl)trimethoxysilane (CAS 4420-74-0) References

  1. Underpotential deposition of thallium, lead, and cadmium at silver electrodes modified with self-assembled monolayers of (3-mercaptopropyl)trimethoxysilane.  |  Robertson, JW., et al. 2007. Langmuir. 23: 4651-61. PMID: 17346068
  2. Electrochemical behavior and determination of fluphenazine at multi-walled carbon nanotubes/(3-mercaptopropyl)trimethoxysilane bilayer modified gold electrodes.  |  Zeng, B. and Huang, F. 2004. Talanta. 64: 380-6. PMID: 18969615
  3. Studies of (3-mercaptopropyl)trimethoxylsilane and bis(trimethoxysilyl)ethane sol-gel coating on copper and aluminum.  |  Li, YS., et al. 2009. Spectrochim Acta A Mol Biomol Spectrosc. 73: 922-8. PMID: 19464230
  4. Stable aqueous ZnS quantum dots obtained using (3-mercaptopropyl)trimethoxysilane as a capping molecule.  |  Li, H., et al. 2007. Nanotechnology. 18: 495605. PMID: 20442479
  5. Hydrogen peroxide sensor based on Prussian blue electrodeposited on (3-mercaptopropyl)-trimethoxysilane polymer-modified gold electrode.  |  Zhang, Y., et al. 2011. Bioprocess Biosyst Eng. 34: 215-21. PMID: 20799044
  6. New nanostructured electrochemical biosensors based on three-dimensional (3-mercaptopropyl)-trimethoxysilane network.  |  Parra-Alfambra, AM., et al. 2011. Analyst. 136: 340-7. PMID: 21072332
  7. Surface modification of silicate glass using 3-(mercaptopropyl)trimethoxysilane for thiol-ene polymerization.  |  Chen, JJ., et al. 2011. Langmuir. 27: 13754-61. PMID: 21870797
  8. Grafting 3-mercaptopropyl trimethoxysilane on multi-walled carbon nanotubes surface for improving on-line cadmium(II) preconcentration from water samples.  |  Corazza, MZ., et al. 2012. J Hazard Mater. 243: 326-33. PMID: 23158690
  9. Occupational contact dermatitis caused by (3-mercaptopropyl)trimethoxysilane in a windscreen repairer.  |  Pesonen, M., et al. 2015. Contact Dermatitis. 73: 372-3. PMID: 26269007
  10. Removal of nickel and cadmium heavy metals using nanofiber membranes functionalized with (3-mercaptopropyl)trimethoxysilane (TMPTMS).  |  Zahabi, SR., et al. 2016. J Water Health. 14: 630-9. PMID: 27441858
  11. Microwave-assisted Synthesis of Hexagonal Gold Nanoparticles Reduced by Organosilane (3-Mercaptopropyl)trimethoxysilane.  |  Shah, KW. and Zheng, L. 2019. Materials (Basel). 12: PMID: 31126101
  12. Enhanced terahertz conductivity in ultra-thin gold film deposited onto (3-mercaptopropyl) trimethoxysilane (MPTMS)-coated Si substrates.  |  Lee, Y., et al. 2019. Sci Rep. 9: 15025. PMID: 31636309
  13. Ultrasound-irradiated synthesis of 3-mercaptopropyl trimethoxysilane-modified hydroxyapatite derived from fish-scale residues followed by ultrasound-assisted organic dyes removal.  |  Sricharoen, P., et al. 2021. Sci Rep. 11: 5560. PMID: 33692430
  14. Hollow Silica Microparticles Based on Amphiphilic Polyphosphazenes.  |  Salinas, Y., et al. 2022. Materials (Basel). 15: PMID: 35888230
  15. Optomagnetic plasmonic nanocircuits.  |  Al-Baiaty, Z., et al. 2019. Nanoscale Adv. 1: 3131-3138. PMID: 36133616

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

(3-Mercaptopropyl)trimethoxysilane, 25 g

sc-231786
25 g
$30.00