3-Amino-1,2,4-triazole 3-Amino-1,2,4-triazole is an irreversible inhibitor of catalase activity. Inhibits imidazoleglycerol-phosphate dehydratase activity and histidine biosynthesis.

3-Amino-1,2,4-triazole  (CAS 61-82-5)

3-Amino-1,2,4-triazole is rated 5.0 out of 5 by 1.
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Synonym: Aminotriazole; Amitrole
Application: An irreversible catalase inhibitor
CAS Number: 61-82-5
Purity: ≥95%
Molecular Weight: 84.08
Molecular Formula: C2H4N4
* Refer to Certificate of Analysis for lot specific data (including water content).
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3-Amino-1,2,4-triazole sc-202016 10 g $31.00

3-Amino-1,2,4-triazole is a small molecule irreversible inhibitor of catalase, an enzyme responsible for converting cellular H2O2 into H2O and O2. Impeding the natural clearance of H2O2 from the cell by catalase has proven useful in studies investigating free radical-mediated damage of cardiac tissue in ischemia. 3-Amino-1,2,4-triazole also shows inhibition of imidazoleglycerol-phosphate dehydratase (HIS3) activity, which interrupts the biosynthesis of histidines. When 3-Amino-1,2,4-triazole is diazotized, the resulting 3-Diazo-1,2,4-triazole is shown to react specifically with tryptophan at acidic pH, presenting a method for determining the tryptophan content of proteins.


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Physical State :
Solubility :
Soluble in water (280 g/l) at 20° C, methanol, ethanol, chloroform, and ethyl acetate (slightly). Insoluble in ether, and acetone.
Storage :
Store at 4° C
Melting Point :
150-153° C (lit.)
Boiling Point :
322.2-373.2° C at 760 mmHg (Predicted)
Density :
~1.5 g/cm3 at 20° C
Refractive Index :
n20D 1.67 (Predicted)
IC50 :
Human immunodeficiency virus type 1 integrase: IC50 = 170 nM (Human immunodeficiency virus 1)
Ki Data :
Imidazolglycerol-phosphate dehydratase: Ki= 30 µM
pK Values :
pKb: 9.40
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
Transport :
UN 3077, Class 9, Packing group III
PubChem CID :
Merck Index :
14: 489
MDL Number :
EC Number :
Beilstein Registry :

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Certificate of Analysis

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3-Amino-1,2,4-triazole Product Citations

See how others have used 3-Amino-1,2,4-triazole. Click on the entry to view the PubMed entry .

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PMID: # 25157103
Son, YO. et al. 2014. Nrf2/p62 signaling in apoptosis resistance and its role in cadmium-induced carcinogenesis. J. Biol. Chem.. 289: 28660-75.

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Rated 5 out of 5 by from Mani Mani, V. et al. (PubMed 26171468) developed a new detection method to determine picomolar concentrations of Amitrole (Aminotriazole; 3-Amino-1,2,4-triazole), an irreversible catalase inhibitor, based on calcium cross linked pectin stabilized gold nanoparticle film modified electrode prepared by electrodeposition. -SCBT Publication Review
Date published: 2015-01-02
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