Molecular structure of 2-Palmitoylglycerol, CAS Number: 23470-00-0
2-Palmitoylglycerol (CAS 23470-00-0)
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Alternate Names:
Hexadecanoic Acid 2-Hydroxy-1-(hydroxymethyl)ethyl Ester
Application:
2-Palmitoylglycerol is a fatty acid glycerol ester that enhances 2-arachidonoylglycerol
CAS Number:
23470-00-0
Molecular Weight:
330.51
Molecular Formula:
C19H38O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
2-Palmitoylglycerol is a fatty acid ester, which increases the ability of 2-arachidonoylglycerol (sc-200794) to bind to CB1 and CB2 cannabinoid receptors. Studies indicate that 2-Palmitoylglycerol also increases the inhibitory activity of 2-arachidonylglycerol on adenylyl cyclase. The inhibitory effects of 2-arachidonylglycerol on TNF alpha (tumor necrosis factor-alpha) by mouse macrophages is enhanced in the presence of 2-Palmitoylglycerol. Furthermore, 2-Palmitoylglycerol may be a key component in modulating pain sensitivity as a result of its ability to interact with endocannabinoids.
2-Palmitoylglycerol (CAS 23470-00-0) References
- Synthesis and biological activities of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, and its metabolically stable ether-linked analogues. | Suhara, Y., et al. 2000. Chem Pharm Bull (Tokyo). 48: 903-7. PMID: 10923815
- 2-Arachidonylglycerol, an endogenous cannabinoid, inhibits tumor necrosis factor-alpha production in murine macrophages, and in mice. | Gallily, R., et al. 2000. Eur J Pharmacol. 406: R5-7. PMID: 11011050
- Endocannabinoids and related fatty acid derivatives in pain modulation. | Walker, JM., et al. 2002. Chem Phys Lipids. 121: 159-72. PMID: 12505698
- The acylation of lipophilic alcohols by lysosomal phospholipase A2. | Abe, A., et al. 2007. J Lipid Res. 48: 2255-63. PMID: 17626977
- A broad investigation of the HBV-mediated changes to primary hepatocyte physiology reveals HBV significantly alters metabolic pathways. | Lamontagne, RJ., et al. 2018. Metabolism. 83: 50-59. PMID: 29410347
- Assessing Cu impacts on freshwater diatoms: biochemical and metabolomic responses of Tabellaria flocculosa (Roth) Kützing. | Gonçalves, S., et al. 2018. Sci Total Environ. 625: 1234-1246. PMID: 29996420
- The potential pathways underlying the association of propyl-paraben exposure with aeroallergen sensitization and EASI score using metabolomics analysis. | Lee, Y., et al. 2021. Sci Rep. 11: 3772. PMID: 33580129
- Co-analysis of cucumber rhizosphere metabolites and microbial PLFAs under excessive fertilization in solar greenhouse. | Wang, S., et al. 2022. Front Microbiol. 13: 1004836. PMID: 36274730
- Metabolomics of the interaction between a consortium of entomopathogenic fungi and their target insect: Mechanisms of attack and survival. | Stuart, AKDC., et al. 2023. Pestic Biochem Physiol. 191: 105369. PMID: 36963938
- Inhibition by 2-arachidonoylglycerol, a novel type of possible neuromodulator, of the depolarization-induced increase in intracellular free calcium in neuroblastoma x glioma hybrid NG108-15 cells. | Sugiura, T., et al. 1997. Biochem Biophys Res Commun. 233: 207-10. PMID: 9144424
- An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity. | Ben-Shabat, S., et al. 1998. Eur J Pharmacol. 353: 23-31. PMID: 9721036
Inhibitor of:
TNF alpha.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2-Palmitoylglycerol, 10 mg | sc-203465 | 10 mg | $66.00 |