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2-Methoxyethanol (CAS 109-86-4)

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Alternate Names:
Ethylene glycol monomethyl ether; Methyl glycol
CAS Number:
109-86-4
Purity:
≥99%
Molecular Weight:
76.09
Molecular Formula:
C3H8O2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2-Methoxyethanol (2-ME) holds a prominent position in scientific research applications due to its wide-ranging utility. This colorless liquid possesses a pleasant scent and readily mixes with water. Its versatility allows for various uses, including synthesis, chemical reactions, and solvent applications. Moreover, it serves as a building block for the production of compound. Within scientific research, 2-Methoxyethanol finds extensive utilization. It acts as a solvent for numerous organic compounds, including alkaloids, steroids, and lipids. Additionally, it serves as a reagent in chemical reactions, facilitating the synthesis of esters and ethers. Notably, the compound assumes a pivotal role in the synthesis of ethylene glycol, ethylene oxide, and ethylene dichloride. The primary metabolic pathway involves the transformation of 2-Methoxyethanol into 2-methoxyacetic acid, subsequently further metabolized into formic acid and carbon dioxide. These processes govern the compound′s biochemical and physiological effects.


2-Methoxyethanol (CAS 109-86-4) References

  1. 2-Methoxyethanol metabolism in pregnant CD-1 mice and embryos.  |  Mebus, CA., et al. 1992. Toxicol Appl Pharmacol. 112: 87-94. PMID: 1733052
  2. Protection against 2-methoxyethanol-induced teratogenesis by serine enantiomers: studies of potential alteration of 2-methoxyethanol pharmacokinetics.  |  Clarke, DO., et al. 1991. Toxicol Appl Pharmacol. 110: 514-26. PMID: 1949018
  3. Testicular gene expression profiling following 2-methoxyethanol and 2-ethoxyethanol exposure in male rats reveals abnormal expression of the actin binding protein cortactin in degenerating spermatocytes.  |  Tonkin, EG., et al. 2009. Toxicol Lett. 190: 193-201. PMID: 19643169
  4. Testicular effect of a mixture of 2-methoxyethanol and 2-ethoxyethanol in rats.  |  Starek-Świechowicz, B., et al. 2015. Pharmacol Rep. 67: 289-93. PMID: 25712652
  5. The effects of 2-methoxyethanol and 2-ethoxyethanol on hematological changes induced by 2-butoxyethanol.  |  Starek-Świechowicz, B., et al. 2015. Med Pr. 66: 303-15. PMID: 26325043
  6. The signal transduction of xanthone as a protector on 2-methoxyethanol-induced cardiac cell damage in mice.  |  Ernawati, ., et al. 2019. J Adv Pharm Technol Res. 10: 184-189. PMID: 31742119
  7. Hepatic oxidative stress, up-regulation of pro-inflammatory cytokines, apoptotic and oncogenic markers following 2-methoxyethanol administrations in rats.  |  Somade, OT., et al. 2020. Biochem Biophys Rep. 24: 100806. PMID: 32913901
  8. Potential neuroprotective of trans-resveratrol a promising agent tempeh and soybean seed coats-derived against beta-amyloid neurotoxicity on primary culture of nerve cells induced by 2-methoxyethanol.  |  Irnidayanti, Y., et al. 2021. Braz J Biol. 82: e235781. PMID: 33787733
  9. A metal-free strategy for the cross-dehydrogenative coupling of 1,3-dicarbonyl compounds with 2-methoxyethanol.  |  Kudale, VS., et al. 2022. Org Biomol Chem. 20: 1226-1230. PMID: 35040852
  10. Selection of a Suitable Solvent Additive for 2-Methoxyethanol-Based Antisolvent-Free Perovskite Film Fabrication.  |  Lee, SH., et al. 2022. ACS Appl Mater Interfaces. 14: 39132-39140. PMID: 35972901
  11. Genotoxicity study of 2-methoxyethanol and benzalkonium chloride through Comet assay using 3D cultured HepG2 cells.  |  Lim, C., et al. 2022. Environ Anal Health Toxicol. 37: e2022031-0. PMID: 36916044
  12. The role of metabolism in 2-methoxyethanol-induced testicular toxicity.  |  Moss, EJ., et al. 1985. Toxicol Appl Pharmacol. 79: 480-9. PMID: 4035689
  13. Pharmacokinetics of 2-methoxyethanol and 2-methoxyacetic acid in the pregnant mouse: a physiologically based mathematical model.  |  Clarke, DO., et al. 1993. Toxicol Appl Pharmacol. 121: 239-52. PMID: 8346541

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2-Methoxyethanol, 1 L

sc-238120
1 L
$95.00

2-Methoxyethanol, 2.5 L

sc-238120A
2.5 L
$156.00