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2-Ketohexanoic acid sodium salt (CAS 13022-85-0)

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Alternate Names:
α-Ketocaproic acid; 2-Ketocaproic acid
Application:
2-Ketohexanoic acid sodium salt is a keto acid commonly utilized in biochemical research to study metabolic pathways and enzyme reactions involving ketone and carboxylate groups.
CAS Number:
13022-85-0
Purity:
≥93%
Molecular Weight:
152.12
Molecular Formula:
C6H9O3Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2-Ketohexanoic acid sodium salt (2-KHA) is a reagent used in various research applications. It is an important intermediate in the synthesis of various organic compounds and is used in the production of pharmaceuticals, agrochemicals, and other fine chemicals. By competitively inhibiting lactate dehydrogenase, 2-Ketohexanoic acid sodium salt can disrupt the glycolytic pathway and affect cellular metabolism. From this, it has been found to inhibit the growth of various cancer cells. It has also been shown to have anti-inflammatory and antioxidant properties.


2-Ketohexanoic acid sodium salt (CAS 13022-85-0) References

  1. Exchanging the substrate specificities of pyruvate decarboxylase from Zymomonas mobilis and benzoylformate decarboxylase from Pseudomonas putida.  |  Siegert, P., et al. 2005. Protein Eng Des Sel. 18: 345-57. PMID: 15930043
  2. Applications of CE-ESI-MS/MS analysis to structural elucidation of methylenecyclohexane ozonolysis products in the particle phase.  |  Müller, C., et al. 2007. Electrophoresis. 28: 1364-70. PMID: 17372940
  3. Characterization of phenylpyruvate decarboxylase, involved in auxin production of Azospirillum brasilense.  |  Spaepen, S., et al. 2007. J Bacteriol. 189: 7626-33. PMID: 17766418
  4. Direct analysis of fatty acid vapors in breath by electrospray ionization and atmospheric pressure ionization-mass spectrometry.  |  Martínez-Lozano, P. and Fernández de la Mora, J. 2008. Anal Chem. 80: 8210-5. PMID: 18821733
  5. Ethyl chloroformate as a derivatizing reagent for the gas chromatographic determination of isoniazid and hydrazine in pharmaceutical preparations.  |  Khuhawar, MY. and Zardari, LA. 2008. Anal Sci. 24: 1493-6. PMID: 18997381
  6. Characterization of a thiamin diphosphate-dependent phenylpyruvate decarboxylase from Saccharomyces cerevisiae.  |  Kneen, MM., et al. 2011. FEBS J. 278: 1842-53. PMID: 21501384
  7. Crystal structures of complexes of the branched-chain aminotransferase from Deinococcus radiodurans with α-ketoisocaproate and L-glutamate suggest the radiation resistance of this enzyme for catalysis.  |  Chen, CD., et al. 2012. J Bacteriol. 194: 6206-16. PMID: 22984263
  8. Mass-Spectrometry-Based Serum Metabolomics of a C57BL/6J Mouse Model of High-Fat-Diet-Induced Non-alcoholic Fatty Liver Disease Development.  |  Lai, YS., et al. 2015. J Agric Food Chem. 63: 7873-84. PMID: 26262841
  9. Transamination of neutral amino acids and 2-keto acids in pancreatic B-cell mitochondria.  |  Lenzen, S., et al. 1985. J Biol Chem. 260: 12629-34. PMID: 2864344
  10. Bioelectrocatalytic Conversion from N2 to Chiral Amino Acids in a H2/α-Keto Acid Enzymatic Fuel Cell.  |  Chen, H., et al. 2020. J Am Chem Soc. 142: 4028-4036. PMID: 32017556
  11. Metabolic plasticity drives development during mammalian embryogenesis.  |  Sharpley, MS., et al. 2021. Dev Cell. 56: 2329-2347.e6. PMID: 34428399
  12. Metabolomics and Lipidomics Signatures of Insulin Resistance and Abdominal Fat Depots in People Living with Obesity.  |  Koay, YC., et al. 2022. Metabolites. 12: PMID: 36557310
  13. Evaluation of Two Simultaneous Metabolomic and Proteomic Extraction Protocols Assessed by Ultra-High-Performance Liquid Chromatography Tandem Mass Spectrometry.  |  Zenati, RA., et al. 2023. Int J Mol Sci. 24: PMID: 36674867
  14. Signal function of metabolism of neutral amino acids and 2-keto acids for initiation of insulin secretion.  |  Lenzen, S., et al. 1982. J Biol Chem. 257: 6631-3. PMID: 7045091
  15. GC-MS profiling of urinary organic acids evaluated as a quantitative method.  |  Duez, P., et al. 1996. Clin Chem. 42: 1609-15. PMID: 8855143
  16. Amino acid use by the gastrointestinal tract of sheep given lucerne forage.  |  MacRae, JC., et al. 1997. Am J Physiol. 273: G1200-7. PMID: 9435544

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2-Ketohexanoic acid sodium salt, 250 mg

sc-225437
250 mg
$215.00

2-Ketohexanoic acid sodium salt, 500 mg

sc-225437A
500 mg
$408.00

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. 2-Ketohexanoic acid sodium salt, sc-225437, is in white powder form.
Answered by: Chemical Support 4
Date published: 2017-04-18
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Rated 5 out of 5 by from Duez P; et alDuez P; et al. (PubMed ID: 8855143) 2-Ketohexanoic acid sodium salt as an internal standard in quantifying keto acids. -SCBT Publication Review
Date published: 2015-04-07
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2-Ketohexanoic acid sodium salt is rated 5.0 out of 5 by 1.
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