Date published: 2025-10-18

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2-Amino-6-chloro-4-nitrophenol (CAS 6358-09-4)

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Alternate Names:
3-Chloro-2-hydroxy-5-nitroaniline
CAS Number:
6358-09-4
Molecular Weight:
188.57
Molecular Formula:
C6H5ClN2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2-Amino-6-chloro-4-nitrophenol is primarily used as an intermediate in the synthesis of a variety of dyes and pigments due to its ability to participate in a range of chemical reactions. It is valuable in the field of materials science for the creation of colorants and is also utilized in the production of compounds that are relevant for electronic and photonic applications. In addition, this compound is of interest for its potential use in the development of colorimetric sensors that can detect specific analytes based on color changes. Researchers are engaged in exploring its role in various synthesis pathways that could lead to innovative materials with desirable properties for industrial applications. The compound′s involvement in the generation of novel colorimetric sensors is particularly notable, as it could lead to advancements in diagnostic and environmental monitoring technologies.


2-Amino-6-chloro-4-nitrophenol (CAS 6358-09-4) References

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  2. Computer-aided knowledge generation for understanding skin sensitization mechanisms: the TOPS-MODE approach.  |  Estrada, E., et al. 2003. Chem Res Toxicol. 16: 1226-35. PMID: 14565764
  3. Read-across to rank skin sensitization potential: subcategories for the Michael acceptor domain.  |  Schultz, TW., et al. 2009. Contact Dermatitis. 60: 21-31. PMID: 19125718
  4. Assessing toxicological data quality: basic principles, existing schemes and current limitations.  |  Przybylak, KR., et al. 2012. SAR QSAR Environ Res. 23: 435-59. PMID: 22507180
  5. Mechanism-Based QSAR Modeling of Skin Sensitization.  |  Dearden, JC., et al. 2015. Chem Res Toxicol. 28: 1975-86. PMID: 26382665
  6. Suitability of the in vitro Caco-2 assay to predict the oral absorption of aromatic amine hair dyes.  |  Obringer, C., et al. 2016. Toxicol In Vitro. 32: 1-7. PMID: 26578466
  7. Accounting for data variability, a key factor in in vivo/in vitro relationships: application to the skin sensitization potency (in vivo LLNA versus in vitro DPRA) example.  |  Dimitrov, S., et al. 2016. J Appl Toxicol. 36: 1568-1578. PMID: 27080242
  8. Survey of sensitizing components of oxidative hair dyes (retail and professional products) in Germany.  |  Kirchlechner, S., et al. 2016. J Dtsch Dermatol Ges. 14: 707-15. PMID: 27373245
  9. 2-Amno-6-Chloro-4-Nitrophenol.  |  Fiume, MM. 2017. Int J Toxicol. 36: 22S-23S. PMID: 29025341
  10. [Determination of 40 dyes in oxidative hair dye products by high performance liquid chromatography].  |  Zuo, X., et al. 2021. Se Pu. 39: 1222-1229. PMID: 34677017
  11. Theoretical and experimental studies of two Co(II) and Ni(II) coordination complex with N,O donor 2-chloro-6-{[(4-hydroxy-3-methoxyphenyl)methylidene]amino}-4 nitrophenol ligand  |  Brajendra S. Kusmariya a, Sandeep Tiwari b, Anjali Tiwari a, A.P. Mishra a, Gowhar Ahmad Naikoo c, Umar J. Pandit a. 2016,. Journal of Molecular Structure. 1116: 279-291.
  12. Theoretical and experimental studies of Cu(II) and Zn(II) coordination compounds with N,O donor bidentate Schiff base ligand containing amino phenol moiety  |  Brajendra S. Kusmariya a, Anjali Tiwari a, A.P. Mishra a, Gowhar Ahmad Naikoo b. 2016. Journal of Molecular Structure. 1119: 115-123.
  13. Co(II), Ni(II), Cu(II) and Zn(II) complexes of tridentate ONO donor Schiff base ligand: Synthesis, characterization, thermal, non-isothermal kinetics and DFT calculations  |  Brajendra S. Kusmariya, A.P. Mishra. 2017. Journal of Molecular Structure. 1130: 727-738.
  14. Synthesis, structural analysis, in vitro antioxidant, antimicrobial activity and molecular docking studies of transition metal complexes derived from Schiff base ligands of 4-(benzyloxy)-2-hydroxybenzaldehyde  |  Jai Devi, Sanjeev Kumar, Binesh Kumar, Sonika Asija & Ashwani Kumar. 2022. Research on Chemical Intermediates. 48: 1541–1576.
  15. Co(II), Ni(II), Cu(II) and Zn(II) complexes of Schiff base ligands: synthesis, characterization, DFT, in vitro antimicrobial activity and molecular docking studies  |  Sanjeev Kumar, Jai Devi, Amit Dubey, Deepak Kumar, Deepak Kumar Jindal, Sonika Asija & Archana Sharma. 2023. Research on Chemical Intermediates. 49: 939–965.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2-Amino-6-chloro-4-nitrophenol, 5 g

sc-472933
5 g
$240.00