Date published: 2025-11-20

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2,6-TDI (CAS 91-08-7)

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CAS Number:
91-08-7
Molecular Weight:
174.16
Molecular Formula:
C9H6N2O2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2,6-TDI, also known as 2,6-Toluene Diisocyanate, is a pivotal chemical compound primarily employed in the synthesis of polyurethanes, showcasing a broad spectrum of applicability in the realm of materials science and industrial chemistry. The mechanism of action of 2,6-TDI involves its reactivity with polyols to form polyurethanes through a process known as polymerization, where the diisocyanate components of 2,6-TDI interact with alcohol groups in polyols to create long, chain-like molecular structures. This reaction is for the production of a diverse array of polyurethane products, ranging from flexible foams used in upholstery to rigid foams for insulation materials, elastomers, and coatings. The unique chemical properties of 2,6-TDI, including its specific isomeric composition and reactivity, make it an essential substance in research focused on developing advanced materials with tailored properties such as enhanced durability, resistance to various environmental factors, and specific mechanical characteristics. Furthermore, the study of 2,6-TDI and its applications in polyurethane production continues to be a significant area of interest in material science research, aiming to optimize the efficiency and environmental sustainability of these processes.


2,6-TDI (CAS 91-08-7) References

  1. A comparative respiratory sensitization study of 2,4- and 2,6-toluene diisocyanate using guinea pigs.  |  Shiotsuka, RN., et al. 2000. Inhal Toxicol. 12: 605-15. PMID: 10880147
  2. Exposure to 2,4- and 2,6-toluene diisocyanate (TDI) during production of flexible foam: determination of airborne TDI and urinary 2,4- and 2,6-toluenediamine (TDA).  |  Kääriä, K., et al. 2001. Analyst. 126: 1025-31. PMID: 11478630
  3. Development, validation and characterization of an analytical method for the quantification of hydrolysable urinary metabolites and plasma protein adducts of 2,4- and 2,6-toluene diisocyanate, 1,5-naphthalene diisocyanate and 4,4'-methylenediphenyl diisocyanate.  |  Sennbro, CJ., et al. 2003. Biomarkers. 8: 204-17. PMID: 12944173
  4. Improvement in the GC-MS method for determining urinary toluene-diamine and its application to the biological monitoring of workers exposed to toluene-diisocyanate.  |  Sakai, T., et al. 2005. Int Arch Occup Environ Health. 78: 459-66. PMID: 15918038
  5. Biological monitoring of isocyanates and related amines. IV. 2,4- and 2,6-toluenediamine in hydrolysed plasma and urine after test-chamber exposure of humans to 2,4- and 2,6-toluene diisocyanate.  |  Brorson, T., et al. 1991. Int Arch Occup Environ Health. 63: 253-9. PMID: 1660449
  6. The GSTP1 Ile105 Val polymorphism modifies the metabolism of toluene di-isocyanate.  |  Broberg, KE., et al. 2010. Pharmacogenet Genomics. 20: 104-11. PMID: 20032816
  7. Biological monitoring as a valid tool to assess occupational exposure to mixtures of 2,4-:2,6-toluene diisocyanate.  |  De Palma, G., et al. 2012. Med Lav. 103: 361-71. PMID: 23077796
  8. Development of a method for quantification of toluene diisocyanate and methylenediphenyl diisocyanate migration from polyurethane foam sample surface to artificial sweat by HPLC-UV-MS.  |  Donchenko, A., et al. 2020. J Chromatogr B Analyt Technol Biomed Life Sci. 1142: 122027. PMID: 32145637
  9. An Ab Initio Investigation on Relevant Oligomerization Reactions of Toluene Diisocyanate (TDI).  |  Thangaraj, R., et al. 2022. Polymers (Basel). 14: PMID: 36236129
  10. Determination of toluenediamine isomers by capillary gas chromatography and chemical ionization mass spectrometry with special reference to the biological monitoring of 2,4- and 2,6-toluene diisocyanate.  |  Skarping, G., et al. 1994. J Chromatogr A. 663: 199-210. PMID: 8173666
  11. Toxicokinetics of 2,4- and 2,6-toluenediamine in hydrolysed urine and plasma after occupational exposure to 2,4- and 2,6- toluene diisocyanate.  |  Lind, P., et al. 1996. Occup Environ Med. 53: 94-9. PMID: 8777457
  12. Formation, solvolysis, and transcarbamoylation reactions of bis(S-glutathionyl) adducts of 2,4- and 2,6-diisocyanatotoluene.  |  Day, BW., et al. 1997. Chem Res Toxicol. 10: 424-31. PMID: 9114980
  13. Albumin adducts in plasma from workers exposed to toluene diisocyanate.  |  Lind, P., et al. 1997. Analyst. 122: 151-4. PMID: 9124697

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2,6-TDI, 1 g

sc-231220
1 g
$56.00