Molecular structure of 11-Hydroxylauric Acid
11-Hydroxylauric Acid (CAS 32459-66-8)
See product citations (3)
Alternate Names:
11-Hydroxydodecanoic Acid
Application:
11-Hydroxylauric Acid is a biochemical used as a substrate to determine the functional expression and characterization of cytochrome P450 52A21.
CAS Number:
32459-66-8
Molecular Weight:
216.32
Molecular Formula:
C12H24O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
11-Hydroxylauric Acid is a biochemical used as a substrate to determine the functional expression and characterization of cytochrome P450 52A21. The binding of 11-Hydroxylauric acid to the retinoic acid receptor results in the inhibition of fatty acid synthesis. This effect may be attributed to its ability to prevent all-trans-retinoic acid from binding to the retinoic acid receptor. Additionally, 11-Hydroxylauric acid acts as an inhibitor of fatty acid synthase, an enzyme responsible for the formation of long chain fatty acids from acetate.
11-Hydroxylauric Acid (CAS 32459-66-8) References
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- Molecular basis for the omega-regiospecificity of the CYP4A2 and CYP4A3 fatty acid hydroxylases. | Hoch, U., et al. 2000. J Biol Chem. 275: 26952-8. PMID: 10869363
- Determination of CYP4A11-catalyzed lauric acid 12-hydroxylation by high-performance liquid chromatography with radiometric detection. | Crespi, CL., et al. 1998. Methods Mol Biol. 107: 163-7. PMID: 14577226
- The effect of isoniazid on CYP2E1- and CYP4A-mediated hydroxylation of arachidonic acid in the rat liver and kidney. | Poloyac, SM., et al. 2004. Drug Metab Dispos. 32: 727-33. PMID: 15205388
- Drosophila melanogaster CYP6A8, an insect P450 that catalyzes lauric acid (omega-1)-hydroxylation. | Helvig, C., et al. 2004. Biochem Biophys Res Commun. 325: 1495-502. PMID: 15555597
- Cytochrome P450 probe substrate metabolism kinetics in Sprague Dawley rats. | Chovan, JP., et al. 2007. Xenobiotica. 37: 459-73. PMID: 17523050
- Determination of the cytochrome P-450 IV marker, omega-hydroxylauric acid, by high-performance liquid chromatography and fluorimetric detection. | Dirven, HA., et al. 1991. J Chromatogr. 564: 266-71. PMID: 1860919
- Cloning and expression of three rabbit kidney cDNAs encoding lauric acid omega-hydroxylases. | Johnson, EF., et al. 1990. Biochemistry. 29: 873-9. PMID: 2340280
- P450BM3 fused to phosphite dehydrogenase allows phosphite-driven selective oxidations. | Beyer, N., et al. 2017. Appl Microbiol Biotechnol. 101: 2319-2331. PMID: 27900443
- Cytochrome P450 4A11 inhibition assays based on characterization of lauric acid metabolites. | Choi, YJ., et al. 2018. Food Chem Toxicol. 112: 205-215. PMID: 29305929
- Cytochrome P-450K of rat kidney cortex microsomes: further studies on its interaction with fatty acids. | Ellin, A., et al. 1973. Arch Biochem Biophys. 158: 597-604. PMID: 4782524
- Cytochrome P-450 induction by clofibrate. Purification and properties of a hepatic cytochrome P-450 relatively specific for the 12- and 11-hydroxylation of dodecanoic acid (lauric acid). | Gibson, GG., et al. 1982. Biochem J. 203: 161-8. PMID: 7103935
- Heteroatom substitution shifts regioselectivity of lauric acid metabolism from omega-hydroxylation to (omega-1)-oxidation. | Alterman, MA., et al. 1995. Biochem Biophys Res Commun. 214: 1089-94. PMID: 7575514
- Biochemical characterization of lauric acid omega-hydroxylation by a CYP4A1/NADPH-cytochrome P450 reductase fusion protein. | Chaurasia, CS., et al. 1995. Arch Biochem Biophys. 317: 161-9. PMID: 7872779
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
11-Hydroxylauric Acid, 5 mg | sc-490839 | 5 mg | $445.00 |