Molecular structure of 1,2-Distearoyl-sn-glycero-3-phosphocholine, CAS Number: 816-94-4
1,2-Distearoyl-sn-glycero-3-phosphocholine (CAS 816-94-4)
Alternate Names:
3-sn-Phosphatidylcholine
Application:
1,2-Distearoyl-sn-glycero-3-phosphocholine is used to produce non-pyrogenic liposome capable of caging molecules
CAS Number:
816-94-4
Purity:
≥98%
Molecular Weight:
790.15
Molecular Formula:
C44H88NO8P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
1,2-Distearoyl-sn-glycero-3-phosphocholine is a non-pyrogenic phospholipid that may act to form well-defined liposomes that are capable of being loaded with a molecule of choice. This loading and vessicle formation is reportedly accomplished simply by a single hydration step. Research has shown that this encapsulation technique may act to increase the uptake for 125I-labelled polyvinylpyrrolidone by four times in an intestinal sac preparation from adult rats. More recently, compounds such as 5-fluorouracil (sc-207031), cyclosporin A (sc-3503) and celecoxib (sc-217869) have been used in this lipid encapsulation technique.
1,2-Distearoyl-sn-glycero-3-phosphocholine (CAS 816-94-4) References
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- Celecoxib-loaded liposomes: effect of cholesterol on encapsulation and in vitro release characteristics. | Deniz, A., et al. 2010. Biosci Rep. 30: 365-73. PMID: 19900165
- Solubilisation of drugs within liposomal bilayers: alternatives to cholesterol as a membrane stabilising agent. | Ali, MH., et al. 2010. J Pharm Pharmacol. 62: 1646-55. PMID: 21039548
- Development of a liposomal nanoparticle formulation of 5-fluorouracil for parenteral administration: formulation design, pharmacokinetics and efficacy. | Thomas, AM., et al. 2011. J Control Release. 150: 212-9. PMID: 21094191
- DSPC/DLPC mixed films supported on silica: a QCM-D and friction force study. | Oguchi, T., et al. 2011. J Oleo Sci. 60: 177-83. PMID: 21427514
- Interfacial molecular interactions based on the conformation recognition between the insoluble antitumor drug AD-1 and DSPC. | Yin, T., et al. 2016. Colloids Surf B Biointerfaces. 146: 902-9. PMID: 27469574
- ATRA Entrapped in DSPC Liposome Enhances Anti-metastasis Effect on Lung and Liver During B16F10 Cell Line Metastasis in C57BL6 Mice. | Reji, RM., et al. 2017. Anticancer Agents Med Chem. 17: 875-884. PMID: 27677688
- Design of lipid nanoparticles for in vitro and in vivo delivery of plasmid DNA. | Kulkarni, JA., et al. 2017. Nanomedicine. 13: 1377-1387. PMID: 28038954
- Recent advancements in the sonophotocatalysis (SPC) and doped-sonophotocatalysis (DSPC) for the treatment of recalcitrant hazardous organic water pollutants. | Panda, D. and Manickam, S. 2017. Ultrason Sonochem. 36: 481-496. PMID: 28069236
- Phase behavior of DSPC/PEG40St mixtures at higher emulsifier contents. | Kilic, S. and Bolukcu, ES. 2018. Colloids Surf B Biointerfaces. 171: 368-376. PMID: 30059852
- Development and evaluation of stability and ultrasound response of DSPC-DPSG-based freeze-dried microbubbles. | Unga, J., et al. 2019. J Liposome Res. 29: 368-374. PMID: 30526185
- On the role of helper lipids in lipid nanoparticle formulations of siRNA. | Kulkarni, JA., et al. 2019. Nanoscale. 11: 21733-21739. PMID: 31713568
- Study of Structural stability and formation mechanisms in DSPC and DPSM liposomes: A coarse-grained molecular dynamics simulation. | Hashemzadeh, H., et al. 2020. Sci Rep. 10: 1837. PMID: 32020000
- Nano-mechanical characterization of asymmetric DLPC/DSPC supported lipid bilayers. | Kamble, S., et al. 2021. Chem Phys Lipids. 234: 105007. PMID: 33160952
- The uptake of distearoylphosphatidylcholine/cholesterol liposomes by rat intestinal sacs in vitro. | Rowland, RN. and Woodley, JF. 1981. Biochim Biophys Acta. 673: 217-23. PMID: 7213821
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
1,2-Distearoyl-sn-glycero-3-phosphocholine, 50 mg | sc-202871 | 50 mg | $51.00 | |||
1,2-Distearoyl-sn-glycero-3-phosphocholine, 250 mg | sc-202871A | 250 mg | $115.00 | |||
1,2-Distearoyl-sn-glycero-3-phosphocholine, 1 g | sc-202871B | 1 g | $255.00 |