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1,2-Dioleoyl-sn-glycerol (CAS 24529-88-2)

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Application:
1,2-Dioleoyl-sn-glycerol is an analog of protein kinase C-activating second messenger DAG
CAS Number:
24529-88-2
Purity:
>95%
Molecular Weight:
621.0
Molecular Formula:
C39H72O5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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1,2-Dioleoyl-sn-glycerol is a chemical compound that has been extensively studied in scientific research, particularly in the field of lipid biochemistry and cellular signaling pathways. It plays a crucial role in investigating the mechanisms of lipid-mediated cellular processes. 1,2-Dioleoyl-sn-glycerol is a synthetic lipid molecule that mimics the structure of natural glycerolipids found in cell membranes. It has been used as a model compound to explore lipid-related phenomena such as lipid-protein interactions, membrane fusion, and intracellular signaling. Through its interaction with various proteins, 1,2-Dioleoyl-sn-glycerol can activate signaling pathways involved in important cellular processes like cell growth, differentiation, and apoptosis. Researchers have utilized this compound to explain the mechanisms of lipid-mediated signal transduction and to investigate the downstream effects of lipid activation on cellular behavior. Furthermore, 1,2-Dioleoyl-sn-glycerol is employed in the development of lipid-based delivery systems for genetics and drug delivery, as lipids serve as efficient carriers for delivering agents into cells. By studying the mechanisms and properties of 1,2-Dioleoyl-sn-glycerol, scientists gain insights into the fundamental principles of lipid-mediated signaling and can develop innovative strategies for targeted delivery of chemical compounds. This research contributes to advancements in understanding lipid biochemistry, cellular communication, and the development of novel lipid-based systems for various research applications.


1,2-Dioleoyl-sn-glycerol (CAS 24529-88-2) References

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  2. Diacylglycerol acyltransferases from Vernonia and Stokesia prefer substrates with vernolic acid.  |  Yu, K., et al. 2006. Lipids. 41: 557-66. PMID: 16981434
  3. Role of the hydrophobic segment of diacylglycerol kinase epsilon.  |  Dicu, AO., et al. 2007. Biochemistry. 46: 6109-17. PMID: 17455907
  4. Effect of phorbol diesters, synthetic diacylglycerols, and a protein kinase C inhibitor on the human sperm acrosome reaction.  |  De Jonge, CJ., et al. 1991. J Androl. 12: 62-70. PMID: 1849129
  5. Hydrolysis of neutral lipid substrates by rat hepatic lipase.  |  Wilcox, RW., et al. 1991. Lipids. 26: 283-8. PMID: 1865764
  6. Diacylglycerol promotes GLUT4 translocation to the cell surface in a PKCε-dependent and PKCλ/ι and -ζ-independent manner.  |  Tsuchiya, A., et al. 2013. Life Sci. 93: 240-6. PMID: 23800645
  7. sn-1,2-diacylglycerols and phorbol diesters: uptake, metabolism, and subsequent assimilation of the diacylglycerol metabolites into complex lipids of cultured cells.  |  Welsh, CJ. and Cabot, MC. 1987. J Cell Biochem. 35: 231-45. PMID: 3693423
  8. Stereospecific labeling of the glycerol moiety: synthesis of 1,2-dioleoyl-sn-[3-3H]glycero-3-phospho(1-rac-glycerol).  |  Schmitt, JD., et al. 1995. Chem Phys Lipids. 77: 131-7. PMID: 7586097
  9. Characterization of two second messenger pathways and their interactions in eliciting the human sperm acrosome reaction.  |  Doherty, CM., et al. 1995. J Androl. 16: 36-46. PMID: 7768751
  10. 1-O-hexadecyl-2-O-methyl-sn-glycero-3-phosphocholine inhibits diacylglycerol kinase in WEHI-3B cells.  |  Salari, H., et al. 1993. Biochem Cell Biol. 71: 36-42. PMID: 8392354
  11. Microsomal diacylglycerol acyltransferase in rat parotid and submandibular glands: acylation of 1,2-dioleoyl-sn-glycerol dispersed with phospholipids.  |  Yashiro, K., et al. 1996. Int J Biochem Cell Biol. 28: 895-903. PMID: 8811837

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

1,2-Dioleoyl-sn-glycerol, 10 mg

sc-204958
10 mg
$114.00

1,2-Dioleoyl-sn-glycerol, 25 mg

sc-204958A
25 mg
$170.00