Molecular structure of Z-Cyclopentyl-AP4, CAS Number: 103439-17-4
Z-Cyclopentyl-AP4 (CAS 103439-17-4)
Alternate Names:
cis-(±)-1-Amino-3-phosphonocyclopentane carboxylic acid
Application:
Z-Cyclopentyl-AP4 is is a Group III mGluR (mGluR-4,6) agonist
CAS Number:
103439-17-4
Molecular Weight:
209.14
Molecular Formula:
C6H12NO5P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Group III mGlu receptor agonist that displays higher potency at mGlu4 than mGlu8 (EC50 values are 49 and 124 μM respectively) with no activity at mGlu7. Selectively inhibits synaptic activity in the lateral perforant pathway (IC50 values are 130 and 1859 μM in the lateral and medial perforant pathways respectively). Conformationally restrained analog of L-AP4.
Z-Cyclopentyl-AP4 (CAS 103439-17-4) References
- Structure-function relationships for analogues of L-2-amino-4-phosphonobutanoic acid on the quisqualic acid-sensitive AP4 receptor of the rat hippocampus. | Schulte, MK., et al. 1992. Brain Res. 582: 291-8. PMID: 1327404
- Group III mGluR regulation of synaptic transmission at the SC-CA1 synapse is developmentally regulated. | Ayala, JE., et al. 2008. Neuropharmacology. 54: 804-14. PMID: 18255102
- Metabotropic glutamate receptors mGluR4 and mGluR8 regulate transmission in the lateral olfactory tract-piriform cortex synapse. | Jones, PJ., et al. 2008. Neuropharmacology. 55: 440-6. PMID: 18625254
- Metabotropic glutamate receptors: physiology, pharmacology, and disease. | Niswender, CM. and Conn, PJ. 2010. Annu Rev Pharmacol Toxicol. 50: 295-322. PMID: 20055706
- Metabotropic glutamate receptors as therapeutic targets for cognitive disorders. | Gravius, A., et al. 2010. Curr Top Med Chem. 10: 187-206. PMID: 20170472
- Group III metabotropic glutamate receptors: pharmacology, physiology and therapeutic potential. | Mercier, MS. and Lodge, D. 2014. Neurochem Res. 39: 1876-94. PMID: 25146900
- Novel recognition site for L-quisqualate sensitizes neurons to depolarization by L-2-amino-4-phosphonobutanoate (L-AP4). | Whittemore, ER. and Koerner, JF. 1989. Brain Res. 489: 146-56. PMID: 2545307
- Activation of peripheral group III metabotropic glutamate receptors inhibits pain transmission by decreasing neuronal excitability in the CFA-inflamed knee joint. | Park, EH., et al. 2019. Neurosci Lett. 694: 111-115. PMID: 30472359
Activator of:
mGluR-4, and mGLuR-8.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Z-Cyclopentyl-AP4, 10 mg | sc-204413 | 10 mg | $169.00 | |||
Z-Cyclopentyl-AP4, 50 mg | sc-204413A | 50 mg | $681.00 |