TREK-1 Antibody (F-6): sc-398449

TREK-1 Antibody (F-6) is a mouse monoclonal IgM antibody that detects TREK-1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-TREK-1 antibody (F-6) is available as the non-conjugated form. TREK-1, also known as TWIK-related K+ channel, plays a crucial role in maintaining the resting membrane potential and regulating cellular excitability, which is vital for proper neuronal function and muscle contraction. TREK-1 is primarily located in the plasma membrane of various cell types, including neurons and epithelial cells, where TREK-1 contributes to physiological responses to mechanical stress and changes in membrane tension. TREK-1′s ability to respond to mechanical stimuli and fatty acids underscores its importance in various physiological processes, including pain sensation and cardiovascular function. TREK-1 is characterized by two pore-forming domains and four transmembrane segments, and shares significant sequence identity with TREK-2, which is predominantly expressed in the cerebellum, spleen, and testis. TREK-1 expression in tissues such as the lung and brain highlights potential involvement in respiratory and neurological functions, making TREK-1 a valuable target for research in these areas.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

TREK-1 Antibody (F-6) References:

1. TREK-2, a new member of the mechanosensitive tandem-pore K+ channel family.  |  Bang, H., et al. 2000. J Biol Chem. 275: 17412-9. PMID: 10747911
2. Molecular biology of voltage-dependent potassium channels.  |  Pongs, O. 1992. Physiol Rev. 72: S69-88. PMID: 1438587
3. Mechanosensitive TREK-1 two-pore-domain potassium (K2P) channels in the cardiovascular system.  |  Wiedmann, F., et al. 2021. Prog Biophys Mol Biol. 159: 126-135. PMID: 32553901
4. Activation of TREK-1 (K2P2.1) potassium channels protects against influenza A-induced lung injury.  |  Zyrianova, T., et al. 2023. Am J Physiol Lung Cell Mol Physiol. 324: L64-L75. PMID: 36410022
5. TREK-1 in the heart: Potential physiological and pathophysiological roles.  |  Bechard, E., et al. 2022. Front Physiol. 13: 1095102. PMID: 36620226
6. TREK-1 and TREK-2 Knockout Mice Are Not Resistant to Halothane or Isoflurane.  |  Spencer, KA., et al. 2023. Anesthesiology. 139: 63-76. PMID: 37027798
7. Novel potent blockers for TWIK-1/TREK-1 heterodimers as potential antidepressants.  |  Lee, EH., et al. 2023. Biomed Pharmacother. 165: 115139. PMID: 37454597
8. Potassium channels and their evolving gates.  |  Jan, LY. and Jan, YN. 1994. Nature. 371: 119-22. PMID: 8072541
9. Eight potassium channel families revealed by the C. elegans genome project.  |  Wei, A., et al. 1996. Neuropharmacology. 35: 805-29. PMID: 8938713
10. Cloning, functional expression and brain localization of a novel unconventional outward rectifier K+ channel.  |  Fink, M., et al. 1996. EMBO J. 15: 6854-62. PMID: 9003761
11. A mammalian two pore domain mechano-gated S-like K+ channel.  |  Patel, AJ., et al. 1998. EMBO J. 17: 4283-90. PMID: 9687497
12. TRAAK is a mammalian neuronal mechano-gated K+ channel.  |  Maingret, F., et al. 1999. J Biol Chem. 274: 1381-7. PMID: 9880510

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TREK-1 Antibody (F-6) has 11 citations in a variety of scientific publications.

Primary antibodies like Anti-TREK-1 Antibody (F-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TREK-1 Antibody (F-6) Specifications

Alternate Product Name: TREK-1

Product Clone Name: F-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 354-380

Epitope Target: TREK-1

Epitope Species: human

Product Reactivity/Detection: TREK-1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 11 citations in various scientific publications

Available Conjugates/Forms for TREK-1 Antibody (F-6): P: Blocking Peptide