TNF-R2 Antibody (F-3): sc-393614

TNF-R2 Antibody (F-3) is a mouse monoclonal IgG1 antibody that detects TNF-R2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TNF-R2, also known as tumor necrosis factor receptor 2, plays a crucial role in mediating the effects of tumor necrosis factor (TNF), a key cytokine involved in inflammation and immune responses. TNF-R2 is primarily expressed on immune cells and is essential for regulating cell survival, proliferation, and differentiation. TNF-R2 signaling is associated with anti-apoptotic effects, which can influence the progression of various diseases, including cancer and autoimmune disorders. TNF-R2 interaction with TNF activates downstream signaling pathways that can lead to the activation of transcription factors such as NF-kB, promoting cell survival and inflammatory responses. Understanding TNF-R2 function and signaling mechanisms is vital for developing therapeutic strategies targeting inflammatory diseases and cancer, making anti-TNF-R2 antibody (F-3) an invaluable tool for researchers studying these critical biological processes.

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TNF-R2 Antibody (F-3) References:

1. A crucial role for p80 TNF-R2 in amplifying p60 TNF-R1 apoptosis signals in T lymphocytes.  |  Chan, FK. and Lenardo, MJ. 2000. Eur J Immunol. 30: 652-60. PMID: 10671223
2. Apoptotic crosstalk of TNF receptors: TNF-R2-induces depletion of TRAF2 and IAP proteins and accelerates TNF-R1-dependent activation of caspase-8.  |  Fotin-Mleczek, M., et al. 2002. J Cell Sci. 115: 2757-70. PMID: 12077366
3. IFN-gamma prevents TNF-alpha-induced apoptosis in C2C12 myotubes through down-regulation of TNF-R2 and increased NF-kappaB activity.  |  Tolosa, L., et al. 2005. Cell Signal. 17: 1333-42. PMID: 16125053
4. Smurf2 is a TRAF2 binding protein that triggers TNF-R2 ubiquitination and TNF-R2-induced JNK activation.  |  Carpentier, I., et al. 2008. Biochem Biophys Res Commun. 374: 752-7. PMID: 18671942
5. Anti-inflammatory effects of tumour necrosis factor (TNF)-alpha are mediated via TNF-R2 (p75) in tolerogenic transforming growth factor-beta-treated antigen-presenting cells.  |  Masli, S. and Turpie, B. 2009. Immunology. 127: 62-72. PMID: 18795974
6. The effect of intra-articular injection of different concentrations of ozone on the level of TNF-α, TNF-R1, and TNF-R2 in rats with rheumatoid arthritis.  |  Chen, H., et al. 2013. Rheumatol Int. 33: 1223-7. PMID: 23052485
7. Consumption of whole grain/bran rye instead of refined wheat decrease concentrations of TNF-R2, e-selectin, and endostatin in an exploratory study in men with prostate cancer.  |  Zamaratskaia, G., et al. 2020. Clin Nutr. 39: 159-165. PMID: 30685298
8. Cytokine priming reduces dependence on TNF-R2 for TNF-alpha-mediated induction of macrophage nitric oxide generation.  |  Miller, AR., et al. 1996. J Interferon Cytokine Res. 16: 1055-63. PMID: 8974009
9. Pathogenic Mycobacterium tuberculosis evades apoptosis of host macrophages by release of TNF-R2, resulting in inactivation of TNF-alpha.  |  Balcewicz-Sablinska, MK., et al. 1998. J Immunol. 161: 2636-41. PMID: 9725266
10. Antioestrogens enhance tumour necrosis factor receptor 2 (TNF-R2) expression and TNF-R2-mediated proliferation in activated T cells.  |  Komi, J. and Lassila, O. 1998. Scand J Immunol. 48: 254-60. PMID: 9743209

The preferred TNF-R2 antibody is TNF-R2 Antibody (D-2): sc-8041.