Date published: 2026-10-24

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TARDBP 抗体 (41-7.1): sc-100871

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说明书
  • TARDBP抗体(41-7.1)是小鼠单克隆IgG1 κ, 在6篇文献中引用,规格为100 µg/ml
  • 免疫human物种的重组TARDBP
  • 推荐用于 human 来源的TARDBP WB, IP, IF, IHC(P) 和 ELISA检测
  • 目前,我们还没有完成TARDBP 抗体 (41-7.1)的首选二抗检测试剂的鉴定。这项工作正在进行中。
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TARDBP抗体(41-7.1)是一种IgG1 κ小鼠单克隆TARDBP抗体,能够通过蛋白质印迹(WB)、免疫沉淀(IP)、免疫荧光(IF)、免疫组化(IHC,P)和酶联免疫吸附试验(ELISA)检测人源的TARDBP。TARDBP抗体(41-7.1)以非偶联的抗TARDBP抗体形式提供。TARDBP(TAR DNA结合蛋白),也被称为TDP-43,是一种含有两个RRM(RNA识别基序)结构域的核蛋白。它在各种组织中普遍表达,在胎盘、肺、胰腺、脾脏和生殖道中的表达水平最高。TARDBP作为DNA结合蛋白发挥作用,并特异性地结合到HIV的TAR DNA序列基序上。通过与TAR基序的这种关联,TARDBP作为转录抑制因子并抑制HIV-1的转录。TARDBP还可以作为剪接活性的负调节因子,已知参与CFTR(囊性纤维化跨膜受体)的剪接。此外,TARDBP是泛素阳性包涵体的主要成分,在许多神经退行性疾病中都很突出。这表明TARDBP可能在神经退行性疾病的发展中发挥作用。由于存在选择性剪接事件,TARDBP存在各种异构体。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

TARDBP 抗体 (41-7.1) 参考文献:

  1. 肌萎缩侧索硬化症和额颞叶痴呆中的致病性TARDBP突变:疾病相关通路。  |  Barmada, SJ. and Finkbeiner, S. 2010. Rev Neurosci. 21: 251-72. PMID: 21086759
  2. TARDBP突变在TDP-43蛋白病中的分析及突变TDP-43的毒性解读。  |  Gendron, TF., et al. 2013. J Alzheimers Dis. 33 Suppl 1: S35-45. PMID: 22751173
  3. 额颞痴呆的临床表型和放射学检查结果与TARDBP突变有关。  |  Floris, G., et al. 2015. J Neurol. 262: 375-84. PMID: 25408367
  4. TARDBP/TDP-43以MTORC1依赖性和MTORC1非依赖性的方式调节自噬。  |  Ying, Z., et al. 2016. Autophagy. 12: 707-8. PMID: 27050460
  5. TARDBP突变与语义变异原发性进行性失语症、病例报告和文献综述有关。  |  González-Sánchez, M., et al. 2018. Neurocase. 24: 301-305. PMID: 30773994
  6. 在 TARDBP/TDP-43 蛋白病中,PTK2/FAK 通过 SQSTM1/p62 磷酸化调节 UPS 损伤。  |  Lee, S., et al. 2020. Autophagy. 16: 1396-1412. PMID: 31690171
  7. 躯体TARDBP变异是语义性痴呆的原因。  |  van Rooij, J., et al. 2020. Brain. 143: 3827-3841. PMID: 33155043
  8. TDP43在神经变性中的三重控制:自我调节、定位和聚集。  |  Tziortzouda, P., et al. 2021. Nat Rev Neurosci. 22: 197-208. PMID: 33654312
  9. 意大利帕金森病和非典型帕金森病患者中的TARDBP突变。  |  Tiloca, C., et al. 2022. Front Aging Neurosci. 14: 1020948. PMID: 36247987
  10. TARDBP通过改变血管内皮生长因子剪接来促进卵巢癌的发展。  |  He, Y., et al. 2023. Oncogene. 42: 49-61. PMID: 36369320

订购信息

产品名称产品编号规格价格数量收藏夹

TARDBP 抗体 (41-7.1)

sc-100871
100 µg/ml
$339.00

Can sc-100871: TARDBP (41-7.1) monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?

Asked by: jerojero
Thank you for your question. Yes, sc-100871: TARDBP (41-7.1) is recommended for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2023-05-29
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Rated 4 out of 5 by MERB from this work in ICCI have used this antibody on immunocytochemistry and worked well.
Date published: 2017-09-19
Rated 5 out of 5 by TinTin from Excellent choice for TARDP detection!Strong and specific antibody for TARDBP, gives great data in WB, IHC and in IF. Smart choice!
Date published: 2017-01-25
Rated 4 out of 5 by SF from Works very well both both non transfectedWorks very well both both non transfected and transfected 293T whole cell lysates. -SCBT QC
Date published: 2015-07-19
Rated 4 out of 5 by JL from Produced wonderful immunoperoxidase nuclearProduced wonderful immunoperoxidase nuclear staining in formalin-fixed, paraffin-embedded human leiomyosarcoma tissue. -SCBT QC
Date published: 2015-03-16
Rated 4 out of 5 by MC from WB: CrispWB: Crisp, clean band in A-431 whole cell lysate. -SCBT QC
Date published: 2015-02-03
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TARDBP 抗体 (41-7.1) is rated 4.2 out of 5 by 5.
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