CD138/SDC1/Syndecan-1 Antibody (2Q1484): sc-73094
- CD138/SDC1/Syndecan-1 Antibody (2Q1484) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against U266 myeloma cell line of human origin
- recommended for detection of Syndecan-1 of mouse, rat and human origin by WB, IP, IF and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- See CD138/SDC1/Syndecan-1 (A-6): sc-390791 for CD138/SDC1/Syndecan-1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CD138/SDC1/Syndecan-1 Antibody (2Q1484). This work is in progress.
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Syndecan-1 Antibody (2Q1484) is a mouse monoclonal IgG1 antibody that detects Syndecan-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Syndecan-1, also known as CD138, is a type I integral membrane proteoglycan that plays a crucial role in cell signaling and adhesion by serving as a receptor for the extracellular matrix. Syndecan-1 (2Q1484) antibody recognizes protein expression on the basolateral surfaces of epithelial cells, endothelial cells of sprouting capillaries, and embryonic condensing mesenchymal cells, highlighting its importance in tissue development and repair. Anti-Syndecan-1 antibody (2Q1484) detects interactions with various extracellular matrix components, including collagens, fibronectin, and thrombospondin, which are essential for maintaining tissue architecture and facilitating cellular communication. Syndecan-1 monoclonal antibody (2Q1484) reveals co-localization with actin-rich filaments, suggesting a role in linking the cytoskeleton to the extracellular matrix, thereby influencing cell shape, motility, and overall cellular function. This multifaceted involvement in cellular processes makes Syndecan-1 a significant target for research in developmental biology and cancer studies, where expression patterns can provide insights into disease mechanisms and potential therapeutic strategies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CD138/SDC1/Syndecan-1 Antibody (2Q1484) References:
- The heparanase/syndecan-1 axis in cancer: mechanisms and therapies. | Ramani, VC., et al. 2013. FEBS J. 280: 2294-306. PMID: 23374281
- Heparanase-Regulated Syndecan-1 Shedding Facilitates Herpes Simplex Virus 1 Egress. | Hadigal, S., et al. 2020. J Virol. 94: PMID: 31827001
- Serum syndecan-1, hyaluronan and thrombomodulin levels in patients with lupus nephritis. | Yu, KYC., et al. 2021. Rheumatology (Oxford). 60: 737-750. PMID: 32793966
- Syndecan-1 Overexpressing Mesothelioma Cells Inhibit Proliferation, Wound Healing, and Tube Formation of Endothelial Cells. | Javadi, J., et al. 2021. Cancers (Basel). 13: PMID: 33562126
- Plasma concentrations of syndecan-1 are dependent on kidney function. | Hahn, RG., et al. 2021. Acta Anaesthesiol Scand. 65: 809-815. PMID: 33595099
- Soluble syndecan-1 and glycosaminoglycans in preeclamptic and normotensive pregnancies. | Hassani Lahsinoui, H., et al. 2021. Sci Rep. 11: 4387. PMID: 33623064
- Serum Syndecan-1 levels in patients with immunoglobulin A vasculitis in children. | Jia, X., et al. 2022. J Pediatr (Rio J). 98: 526-532. PMID: 35240047
- Altered Distribution and Expression of Syndecan-1 and -4 as an Additional Hallmark in Psoriasis. | Koliakou, E., et al. 2022. Int J Mol Sci. 23: PMID: 35742957
- Syndecan 1 may slow the progression of subclinical atherosclerosis in patients with ankylosing spondylitis. | Yilmaz, PD., et al. 2023. Clin Exp Hypertens. 45: 2156529. PMID: 36524421
- Dynamic interplay between sortilin and syndecan-1 contributes to prostate cancer progression. | Lazniewska, J., et al. 2023. Sci Rep. 13: 13489. PMID: 37596305
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD138/SDC1/Syndecan-1 Antibody (2Q1484) | sc-73094 | 100 µg/ml | $322.00 | |||
CD138/SDC1/Syndecan-1 Antibody (2Q1484) FITC | sc-73094 FITC | 100 tests in 2 ml | $336.00 | |||
CD138/SDC1/Syndecan-1 Antibody (2Q1484) PE | sc-73094 PE | 100 tests in 2 ml | $349.00 |